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The second-generation thrombopoietin (TPO) receptor agonists eltrombopag and romiplostim are potent activators of megakaryopoiesis and represent a growing treatment option for patients with thrombocytopenic hematological disorders. Both TPO receptor agonists have been approved worldwide for the treatment of children and adults with chronic immune thrombocytopenia. In the EU and USA, eltrombopag is
Some bacteria have the unique capacity of synthesising ice-nucleation-active (INA) proteins and exposing them at their outer membrane surface. As INA bacteria enter the atmosphere, they may impact the formation of clouds and precipitation. We studied members of airborne bacterial communities for their capacity to catalyse ice formation and we report on the excretion of INA proteins by airborne Pse
Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammator
As semiconducting nanowires have promising applications for materials science, nanoelectronics and photovoltaic devices, absolute control of their structure, morphology and composition is a prerequisite for their functionality. Nanowires, grown through the vapor-liquid-solid (VLS) method, exhibit a complex relationship between their liquid seed particle and what properties, such as the aforementio
A model is established that describes stress driven diffusion, resulting in formation and growth of an expanded precipitate at the tip of a crack. The new phase is transversely isotropic. A finite element method is used and the results are compared with a simplified analytical theory. A stress criterium for formation of the precipitate is derived by direct integration of the Einstein-Smoluchowski
How do early-life conditions affect adult mortality? Research has yielded mixed evidence about the influence of infant and child mortality in birth cohorts on adult health and mortality. Studies rarely consider the specific role of mortality within the family. We estimated how individuals’ exposure to mortality as a child is related to their adult mortality risk between ages 18 and 85 in two histo
The principal question we ask in this study is to what extent structural characteristics in the entrepreneurship eco-system surrounding incubators influence the likelihood that women may engage in the commercialization of university science by becoming incubatees. We embed our arguments in institutional theory and develop hypotheses related to (1) the share of female faculty at the closest univers
It is widely believed that, in contrast to its electron-doped counterparts, the hole-doped compound Ba(1-x)K(x)Fe(2)As(2) exhibits a mesoscopic phase separation of magnetism and superconductivity in the underdoped region of the phase diagram. Here, we report a combined high-resolution x-ray powder diffraction and volume-sensitive muon spin rotation study of Ba(1-x)K(x)Fe(2)As(2) showing that this
Flavor symmetries à la Froggatt-Nielsen provide a compelling way to explain the hierarchies of fermionic masses and mixing angles in the Yukawa sector. In supersymmetric (SUSY) extensions of the Standard Model where the mediation of SUSY breaking occurs at scales larger than the breaking of flavor, this symmetry must be respected not only by the Yukawas of the superpotential but also by the soft-b
Background: Deep learning convolutional neural networks (CNN) may facilitate melanoma detection, but data comparing a CNN's diagnostic performance to larger groups of dermatologists are lacking.Methods: Google's Inception v4 CNN architecture was trained and validated using dermoscopic images and corresponding diagnoses. In a comparative cross-sectional reader study a 100-image test-set was used (l
BACKGROUND: An individual's subjective perception of well-being is increasingly recognized as an essential complement to clinical symptomatology and functional impairment in children's mental health. Measurement of quality of life (QoL) has the potential to give due weight to the child's perspective.SCOPE AND METHODOLOGY: Our aim was to critically review the current evidence on how childhood menta
This chapter explores the themes of sin and punishment through the lens of a theodicy that the authors and redactors of Isaiah offer to justifyYHWH’s actions and to instruct the Israelites to stay loyal to him. The three parts of Isaiah agree that the exile wasYHWH’s punishment for the Israelites’ rebellion demonstrated through social injustice and idolatry. However, because of the different hist
Intradialytic hypotension (IDH) is the most common complication during hemodialysis; early prediction and prevention of IDH would dramatically improve the living conditions for patients with end stage renal disease. A recently published study suggests that a decrease in the envelope of the photoplethysmograpy (PPG) signal can be used for predicting acute symptomatic IDH. In the present study, the
