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This doctoral thesis revolves around the analysis of electrocardiogram (ECG) signals during atrial fibrillation (AF). Special emphasis is put on the atrial fibrillatory waves, sometimes called the f-waves, which is the ECG component reflecting the electrical activity of the atria. The thesis comprises an introduction and five papers that introduce and apply methods on ECG-based analysis of AF. Pap
The research framework of eco-evolutionary dynamics is increasing in popularity, as revealed by a steady stream of review articles and a recent and influential book, but primary empirical research is lagging behind. Moreover, the few empirical case studies demonstrating eco-evolutionary dynamics might not be entirely representative. Much current research on eco-evolutionary dynamics is focused on
Background: Numerous different types of variations can occur in DNA and have diverse effects and consequences. The Variation Ontology (VariO) was developed for systematic descriptions of variations and their effects at DNA, RNA and protein levels. Results: VariO use and terms for DNA variations are described in depth. VariO provides systematic names for variation types and detailed descriptions fo
Growing GaAs nanowires with well-defined crystal structures is a challenging task, but may be required for the fabrication of future devices. In terms of crystal phase selection, the connection between theory and experiment is limited, leaving experimentalists with a trial and error approach to achieve the desired crystal structures. In this work, we present a modeling approach designed to provide
The financing of climate measures in developing countries – climate finance – is an increasingly important issue in global climate governance. While a growing body of literature has highlighted the importance of bureaucratic actors within governments as a factor influencing political decisions, quantitative studies on climate finance have so far only focused on extra-governmental factors. We argue tha
The asymmetries of care and domestic work, currently debated widely in the context of the Covid-19 pandemic, are well documented. Capitalism’s core dependence upon the exploitation of socially reproductive labour extends from the home to the workplace. It is fed by patterns of exploitation replicated globally, from slavery to migrant workers. With this background in mind, integrating social reprod
It is known that any harmonic map of finite uniton number from a Riemann surface into U (n) can be deformed into a new harmonic map with an associated S1-invariant extended solution. We study this deformation in detail using operator-theoretic methods. In particular, we show that the corresponding unitons are real analytic functions of the deformation parameter, and that the deformation is closely
Two series of [(Ln1/3Sr2/3S)1.15] 1.15NbS2 (1.5Q/1H) and (Ln1- Sr S) 1+ NbS2 (1Q/1H) misfit layer sulfides have been synthesised and studied by X-ray powder and single crystal diffraction, EDX-analysis and magnetic measurements. For the early lanthanides (Ln = La, Ce) only the (Ln1- Sr S)1+ NbS2 (< 0.40-0.45, = 0.15-0.17) compounds were formed whereas for late lanthanides (Ln = Pr, Nd, Sm, Gd-Er,
The interaction of antikaons (K) with nucleons and nuclei in the low-energy regime represents a very active research field in hadron physics. A unique and rather direct experimental access to the antikaon-nucleon scattering lengths is provided by precision X-ray spectroscopy of transitions in low-lying states in the lightest kaonic atoms (i.e. kaonic hydrogen and deuterium). In the SIDDHARTA exper
Neuropeptide Y (NPY-(1-36)) acts on Y1 and Y2 receptors at the sympathetic neuroeffector junction. Various truncated NPY analogs were tested in the isolated guinea-pig caval vein where NPY is a vasoconstrictor (Y1 receptors) and in isolated rat vas deferens, by monitoring the suppression of electrically evoked contractions (Y2 receptors). The aim of this study was to define which parts of the NPY-
The water use associated with electricity generation and consumption has been the focus of research for decades. This study provides an overview of the water–electricity nexus from the perspectives of electricity production and consumption. In terms of production, the electricity generation and associated water use for various regions are summarized and compared. The spatial mismatch between water
Biobjective and bidisciplinary optimal design of high-performance airfoil and wing applying two kinds of optimization methods and genetic algorithm are discussed. An objective function combination method (OFCM) of constructing a resultant objective function in DOM or a fitness function in GA for biobjective optimization.
Not only has recombinant DNA added another source of insulin for treatment, but also, and perhaps more important, it has allowed the development of new techniques for studying the structure and function of the B cell at the gene level. We can only hope that this information will bring us closer to the understanding of the disease, so the diabetic patient may benefit from other measures of treatmen
A model based on rate-equation analysis has been developed for simulation of two-photon-excited laser-induced fluorescence of carbon monoxide (CO) in the Hopfield-Birge band at 230 nm. The model has been compared with experimental fluorescence profiles measured along focused beams provided by lasers emitting nano-, pico-, and femtosecond pulses. Good quantitative agreement was obtained between sim
To elucidate the role of biogenic amines in insulin secretion, pancreatic islets rich in β-cells were microdissected from obese-hyperglycemic mice and were incubated with 14C-labelled 5-hydroxytryptamine (5-HT). The saturability of uptake and the fact that 5-HT was accumulated to high levels indicated that the β-cells possess a transport system with great capacity for this amine. The initial uptak
Proteinase activated receptor-2 plays a crucial role in a wide variety of conditions with a strong inflammatory component. We present the discovery and characterization of two structurally different, potent, selective, and metabolically stable small-molecule PAR-2 agonists. These ligands may be useful as pharmacological tools for elucidating the complex physiological role of the PAR-2 receptors as
Recently, the geographical origins of Ashkenazic Jews (AJs) and their native language Yiddish were investigated by applying the Geographic Population Structure (GPS) to a cohort of exclusively Yiddish-speaking and multilingual AJs. GPS localized most AJs along major ancient trade routes in northeastern Turkey adjacent to primeval villages with names that resemble the word "Ashkenaz." These finding
