Filtyp
Streptomyces cells grow by building cell wall at one pole-the hyphal tip. Although analogous to hyphal growth in fungi, this is achieved in a prokaryote, without any of the well-known eukaryotic cell polarity proteins, and it is also unique among bacterial cases of cell polarity. Further, polar growth of Streptomyces and the related mycobacteria and corynebacteria is independent of the MreB cytosk
This paper presents the design of a two-step process in which the first step is PEGylation of a protein, and the second step is chromatographic purification of the target mono-PEGylated protein from the unreacted and the di-PEGylated impurities. The difference between optimizing each process step separately and optimizing them simultaneously is studied. It was found that by optimizing the steps si
Increased recirculation of process water has given rise to problems with formation of calcium oxalate incrusts (scaling) in the pulp and paper industry and in forest biorefineries. The potential in using oxalate decarboxylase from Aspergillus niger for oxalic acid removal in industrial bleaching plant filtrates containing oxalic acid was examined and compared with barley oxalate oxidase. Ten diffe
In the past years, research on military applications of neuroscience has grown in sophistication. We may expect that future neuroweapons will be advertised as resting on the most objective form of human cognition, leading to greater accuracy in targeting and better compliance with the law than traditional weapons. Are states using weapon systems that draw on neuroscience capable of applying IHL to
We study localization, urbanization and Jacobs’ externality effects on plant survival in Sweden (1970–2004). We focus on two questions: (i) do agglomeration externalities change with the age of plants? and (ii) what is the role of technological relatedness among local industries? We find that agglomeration externalities affect survival chances of plants. This effect, however, differs between corpo
We show conditional lower bounds for well-studied #P-hard problems: -The number of satisfying assignments of a 2-CNF formula with n variables cannot be computed in time exp(o(n)), and the same is true for computing the number of all independent sets in an n-vertex graph. -The permanent of an n x n matrix with entries 0 and 1 cannot be computed in time exp(o(n)). -The Tutte polynomial of an n-verte
We investigate the Derjaguin approximation by explicitly determining the interactions between two spherical colloids using density functional theory solved in cylindrical coordinates. The colloids are composed of close-packed Lennard-Jones particles. The solvent particles are also modeled via Lennard-Jones interactions. Cross interactions are assumed to follow the commonly used Lorentz-Berthelot (
Objective The objective of this article is to determine if maternal obesity is associated with an increased risk of Down syndrome in the offspring and whether the risk estimates for trisomy 21 based on combined screening is affected by maternal body mass index (BMI). Methods Study group I consisted of a nationwide cohort of 1 568 604 women giving birth; outcome was infants born with Down syndrome
The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://www.C-HPP.org), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most
Friction is an important phenomenon in everyday life. All children are familiar with playground slides, which may thus be a good starting point for investigating friction. Motion on an inclined plane is a standard physics example. This paper presents an investigation of friction by a group of 11-year olds. How did they plan their investigations? What aspects of friction could they discern? What un
The paper presents results from the experimental testing of load-bearing timber–glass composite shear walls and beams. Shear wall specimens measuring 1200 × 2400 mm2 manufactured with three adhesives of varying stiffness were tested. Twelve specimens with a single 10 mm thick glass pane and one specimen with an additional insulating glass unit were produced. The testing procedures involved various
Present work aims at evaluation of contemporary comprehensive detailed kinetic mechanisms for ethylene combustion, including the Konnov mechanism, LLNL nButane mechanism, San Diego (UCSD) mechanism and USC mechanism. These models have been validated by extensive comparison with available experimental data on ethylene ignition and flame propagation. The experimental data from the literature have be
Compartmentalized systems produced via the layer-by-layer (LbL) self-assembly method have been produced by alternatively depositing alginate and chitosan layers onto cores of liposomes. The combination of dynamic light scattering (DLS), zeta potential, and transmission electron microscopy (TEM) techniques provides detailed information on the stability, dimensions, charge, and wall thickness of the
Popular Abstract in Swedish Hur begreppet religion kan klargöras eller definieras är en mycket omtvistad fråga inom åtskilliga akademiska discipliner. Två huvudsakliga negativa tendenser är märkbara inom gängse och aktuell teoribildning. För det första har det framkastats en mängd divergerande definitionsförslag under årens lopp. Detta har bland annat lett till en teoretisk uppgivenhet inför uppgiIt is a contested question in contemporary theories of religion whether the concept of religion can be defined in a sound way or not. Many theorists maintain that a universal but delimiting definition is impossible. In this study, by contrast, it is argued that a conceptual analysis of religion that holds universally is perfectly possible because the following thesis can be seen as a necessary and
Understanding the relationship between concepts and experience seems necessary to specifying the content of experience, yet current theories of concepts do not seem up to the job. With Peter Gärdenfors's conceptual spaces theory as a foundation and with enactivist philosophy as inspiration, we present a proposed extension to conceptual spaces theory and use it to outline a model of the emergence o
Popular Abstract in Swedish Utvecklandet av helt nya baspolymerer för tillverkning av massprodukter förväntas i framtiden vara begränsad p.g.a. för höga investeringskostnader. En av de mest tydliga trenderna inom polymerindustrin idag är istället den ökande betydelsen av polymerblandningar. Kombinationer av två eller flera polymerer som bildar fasseparerade strukturer i blandning ger ofta materialOne of the main trends in the polymer industry today is the increasing importance of polymer blends. Combining two or more immiscible polymers in a polymer blend often leads to multi-phase materials with desirable properties. The typical poor morphological stability and low interfacial adhesion in these blends can be eliminated by adding compatibilizing graft copolymers. Well-defined graft copoly
In what has been seen as an age of increasing bureaucratisation, did it matter who was close to the monarch? Since the monarch embodied supreme wordly power, the way in which daily life at court was organised was of great importance. One function of the early modern court was, in the words of Geoffrey Elton, to act as a point of contact between monarch and élite. I have chosen to test this hypothe
Popular Abstract in Swedish Sjögrens syndrom är en autoimmun sjukdom, vilket betyder att immunsystemet felreagerar och angriper kroppens egen vävnad. Nittio procent av dem som får diagnosen är kvinnor, av vilka de flesta är mellan 40 och 60 år. Vid Sjögrens syndrom, som tillhör en av våra vanligaste reumatiska sjukdomar, är det framförallt tår- och spottkörtlar som angrips och blir inflammerade. DPrimary Sjögren’s syndrome (SS) is a chronic autoimmune disease of unknown etiology. The disease primarily involves lachrymal and salivary glands, leading to dryness of the eyes and mouth, but a wide spectrum of exocrine and non-exocrine disease manifestations may be seen. A characteristic property of primary SS is the production of autoantibodies directed against intracellular, often DNA/RNA-modi
