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Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtai
Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 partic
Most chronic and acute lung diseases have no cure, leaving lung transplantation as the only option. Recent work has improved our understanding of the endogenous regenerative capacity of the lung and has helped identification of different progenitor cell populations, as well as exploration into inducing endogenous regeneration through pharmaceutical or biological therapies. Additionally, alternativ
Background The scaphoid is the most commonly fractured carpal bone in adults as well as in children. Previous studies have reported a wide range of fracture incidences. Scaphoid fractures and non-unions in children have been sparsely investigated. Aim To perform a systematic review of the current literature on epidemiology of scaphoid fractures and non-unions in adults and children. Methods An ele
We study the adhesion and tensile behaviour of bi-layer interfaces comprising polyethylene, doped with carbonyl and hydroxyl functional groups emanating from ozone treatment, and - by means of density functional theory and classical atomistic modelling. The results show that the deformations are localized within the polymer and comprise chain slip, disentanglement and detachment from the substrate
Nanowire (NW) arrays containing a top segment of GaxIn1–xP are investigated, comparing NWs grown using two different Ga precursors, trimethylgallium (TMGa) and triethylgallium (TEGa). TMGa is the precursor commonly used for the particle-assisted vapor–liquid–solid (VLS) growth of GaxIn1–xP NWs. However, it shows inefficient pyrolysis at typical NW growth conditions. The use of the alternative prec
Aim: To explore if electrographic status epilepticus (ESE) after cardiac arrest causes additional secondary brain injury reflected by serum levels of two novel biomarkers of brain injury: neurofilament light chain (NfL) originating from neurons and glial fibrillary acidic protein (GFAP) from glial cells. Methods: Simplified continuous EEG (cEEG) and serum levels of NfL and GFAP, sampled at 24, 48
Freely grazing horses are at risk of infection by parasites such as Parascaris equorum (roundworm), Strongylus spp. (large bloodworms), Cyathostomes (small bloodworms), and Anoplochephala perfoliata (tapeworms). Mixed infections are common and diagnosis is based on demonstrations of eggs in feces followed by identification of larvae after fecal culture. Drug resistance is a growing problem, not le
The urban expansion currently under development around the two materials science facilities MAX IV and European Spallation Source in Lund, Sweden, surrounds two meticulously designed research facilities steered by global demands. The new urban area, together with the research facilities dedicated to science and the development of knowledge, expands the city of Lund onto high-quality agricultural
We investigate so-called Laplace–Carleson embeddings for large exponents. In particular, we extend some results by Jacob, Partington, and Pott. We also discuss some related results for Sobolev-and Besov spaces, and mapping properties of the Fourier transform. These variants of the Hausdorff–Young theorem appear difficult to find in the literature. We conclude the paper with an example related to a
Self-assembly of nanoparticles into vertical structures or larger ensembles can be a powerful method to achieve a strong collective behavior while still obtaining many of the same properties of the individual nanoparticles. In this study, we achieve directed self-assembly of magnetic nanoparticles into nanochains when depositing in a combined magnetic and electric field (M-ESP). We show that the C
Cerium doped Gd3Ga3Al2O12 (GGAG) single crystals as well as GGAG:Ce single crystals co-doped by divalent (Mg2+, Ca2+) and tetravalent (Zr4+, Ti4+) ions have been studied by means of time-resolved luminescence as well as the excitation luminescence spectroscopy in vacuum ultraviolet (VUV) and soft X-ray (XUV) spectral range. Tunable laser excitation was applied for time-resolved experiments in orde
Periodontitis is a complex chronic inflammatory noncommunicable disease, initiated by the development of a dysbiotic microbial plaque biofilm below the gingival margin. Whilst the pathogenic biofilm is a “necessary cause” of periodontitis, it is insufficient on its own to cause the disease, and a destructive immune-inflammatory response is a key to the translation of risk to destructive events. Ot
This chapter briefly reviews how bibliometric indicators are used for allocating resources in academia. How these measures can be understood in relation to different evaluation systems is discussed, and various types of applications - including individual level use - are outlined. Furthermore, attention is given to the effect of evaluation in terms of incentives and possible adverse effects. The i
Most state-of-the-art satisfiability algorithms today are variants of the DPLL procedure augmented with clause learning. The main bottleneck for such algorithms, other than the obvious one of time, is the amount of memory used, fn the field of proof complexity, the resources of time and memory correspond to the length and space of resolution proofs. There has been a long line of research trying to
