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Coronary heart disease (CHD) is an archetypical multifactorial disorder that is influenced by genetic susceptibility as well as both modifiable and nonmodifiable risk factors, and their interactions. Advances during recent years in the field of multifactorial genetics, in particular genomewide association studies (GWASs) and their meta-analyses, have provided the statistical power to identify and

Dementia is the most common cause of functional decline among elderly people and is associated with high costs of national healthcare in European countries. With increasing functional and cognitive decline, it is likely that many people suffering from dementia will receive institutional care in their lifetime. To delay entry to institutional care, many European countries invest in home and communi

BACKGROUND: Cancer of unknown primary (CUP) is a fatal cancer for which incidence trends have changed but detailed survival trends remain unexplored. These could point out successful diagnostic and therapeutic approaches. We investigate survival trends in CUP according to histology, locations of metastases and site-specific causes of death. PATIENTS AND METHODS: A total of 20,523 CUP patients with

The discovery that variants in the melatonin receptor 2 (MTNR1B) gene were associated with glucose levels, insulin secretion, and risk for type 2 diabetes (T2D) in genome-wide association studies (GWAS) reinforced the previously suggested link between glucose homeostasis and circadian rhythmicity. Diurnal secretion of melatonin has reported to be altered in people with diabetes and rodent models o

Large-scale food storage has been identified at an Early Mesolithic settlement on the east coast of Sweden, implying a delayed-return subsistence strategy. The excavation and analysis of the contents of a 9200-year-old construction, combined with ethnographic analogies and modern knowledge of microbial activity, suggest that fish was fermented at the site. The identification of a foraging economy

Guided by complexity theory, in this article, we argue that a complex understanding of disaster response management can be achieved by making multiple, transparent and modest interpretations. We suggest an analytical framework in which multiple system interpretations are constructed, all based on explicit analytical choices according to three aspects: (1) system dimension, (2) system scope and (3)

Description and analysis of Swedish excise duties and Swedish tax policy in field of environmental friendly tax incentives

There has been an increased interest in ways of measuring the value of new therapeutic options in oncology. An example of this in a European context is the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS). The purpose of this study is to analyse how the value scales, exemplified with ESMO-MCBS, developed mainly to assist decisions by physicians, relate to other measures of clinical benefit and

Thin films of "complex salts" (CS = ionic surfactants with polymeric counterions) have recently been shown to respond to humidity changes in ambient air by changing their liquid crystalline structure. We here report isotherms and kinetics of water sorption/desorption for ∼10-100 μm films of alkyltrimethylammonium polyacrylate CS, measured in a dynamic gravimetric vapor sorption instrument over a 0

A sorption calorimetry study of cationic cetyltrimethyl ammonium surfactants with four different counterions was performed. The counterions were acetate, succinate, citrate, and butyl tetracarboxylate with formal charges ranging from 1 to 4, respectively. The counterions with 2-4 charges can be considered as oligomers. In all the cases, hydration experiments started with dry solid phases that upon

Dielectric elastomers belong to a larger group of materials, the so-called electroactive polymers, which have the capability of transforming electric energy to mechanical energy through deformation. VHB 4910 is one of the most popularmaterials for applications of dielectric elastomers and therefore one of the most investigated. This paper includes a new micromechanically motivated constitutive mod