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The objective of this study is to explore the inclusiveness of lesbian, gay, bisexual, transgender, and queer (LGBTQ) adolescents in junior high school from the perspective of LGBTQ adolescents in Sweden. Semi-structured in-depth interviews were conducted with 10 GBTQ adolescents, aged 16 to 19. The study was approved by the Swedish Ethical Review Authority (Dnr: 2019-03816). A Braun and Clark ins
Here we discuss the current state of knowledge of terrestrial planet formation from the aspects of different planet formation models and isotopic data from 182Hf-182W, U-Pb, lithophile-siderophile elements, 48Ca/44Ca isotope samples from planetary building blocks, recent reproduction attempts from 36Ar/38Ar, 20Ne/22Ne, 36Ar/22Ne isotope ratios in Venus’ and Earth’s atmospheres, the expected solar
We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria
Cisplatin is one of the most commonly used drugs for the treatment of various solid cancers. However, its efficacy is restricted by severe side effects, especially dose-limiting nephrotoxicity. New platinum-based compounds are designed to overcome this limitation. Previous investigations showed that the platinum(IV)–nitroxyl complex PN149 is highly cytotoxic in various tumor cell lines. In the pre
No-go decay (NGD) targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. The crystal structure of a Schizosaccharomyces pombe Dom34-Hbs1 complex reveals an overall shape similar to that of eRF1-eRF3-GTP and EF-Tu-tRNA-GDPNP. Similarly to eRF1 and GTP binding to eRF3, Dom34 and GTP bind to Hbs1 with strong cooperativity,
RNA polymerases differ functionally and structurally in the initiation phase of transcription, when polymerization of 8-12 nucleotides occurs, from the later phases of transcription. Here we argue that the ribosome also might have different properties when translating the first codons in open reading frames, as compared with the later phases of translation.
BACKGROUND. The incidence of non-Hodgkin lymphoma (NHL) has increased in most Western countries during the last few decades. Immunodefective conditions are established risk factors. In 1981, the authors reported an increased risk for NHL following exposure to certain pesticides. The current study was designed to further elucidate the importance of phenoxyacetic acids and other pesticides in the et
Although β-amyloid (Aβ) plaques and tau neurofibrillary tangles are hallmarks of Alzheimer's disease (AD) neuropathology, loss of synapses is considered the best correlate of cognitive decline in AD, rather than plaques or tangles. How pathological Aβ and tau aggregation relate to each other and to alterations in synapses remains unclear. Since aberrant tau phosphorylation occurs in amyloid precur
Plaques are a defining neuropathological hallmark of Alzheimer's disease (AD) and the major constituent of plaques, the β-amyloid peptide (Aβ), is considered to play an important role in the pathophysiology of AD. But the biological origin of Aβ plaques and the mechanism whereby Aβ is involved in pathogenesis have been unknown. Aβ plaques were thought to form from the gradual accumulation and aggr
The glutamatergic neurotransmission system and the N-methyl-D-aspartate receptor (NMDAR) have been implicated in smoking and alcohol consumption behavior. Preclinical studies have demonstrated that nicotine and ethanol influence NMDAR functionality, which may have a role in tendencies to consume these substances. Nonetheless, little is known about concentrations of NMDAR coagonists in the cerebros
From its inception, leadership studies has embraced the positivist tradition of hypothesis testing. In this tradition, psychometric instruments are meant to ward off belief from scientific practice by testing theories against empirical facts. While leadership scholars purport to conform to the standards of value-neutral science, this paper tells a different story. Drawing on qualitative interviews
The influence of the sintering temperature on the mechanical properties of cBN-based ceramic composites with binders in form of vanadium compounds is investigated by methods of physical material science. Two compositions are selected for the study cBN–VC–Al and cBN–VN–Al with 60% vol. of cBN. Samples are obtained by high pressure high temperature sintering (HPHT) in toroid type apparatus with cent
In this Letter, we report for the first time, to the best of our knowledge, the possibility of visualizing an atomizing spray by simultaneously recording x-ray absorption and two-photon laser-induced fluorescence imaging. This unique illumination/detection scheme is made possible due to the use of soft x rays emitted from a laser-driven x-ray source. An 800 mJ laser pulse of 38 fs duration is used
Resolving International Conflict rethinks the dynamics of conflict escalation and continuation by engaging with research from the wide range of subfields in this area.The book suggests a new framework for understanding conflict as a particular form of situation, interaction and tension. It shows how conflicts are shaped by varied dynamics relating to emotion, securitization, incentives, digital te
Refugees have moved into the spotlight of public debate in Europe and North America, where they are targeted by multiple welfare state interventions. This volume analyses the tensions that emerge within the strong welfare states of Northern Europe when faced with an increased immigration of protection-seeking people. Examining the encounter between refugees and the welfare states, this book explor
To what extent does the visual system process color and form separately? Proponents of the segregation view claim that distinct regions of the cortex are dedicated to each of these two dimensions separately. However, evidence is accumulating that color and form processing may, at least to some extent, be intertwined in the brain. In this perspective, we review psychophysical and neurophysiological
