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Periodontitis is a complex chronic inflammatory noncommunicable disease, initiated by the development of a dysbiotic microbial plaque biofilm below the gingival margin. Whilst the pathogenic biofilm is a “necessary cause” of periodontitis, it is insufficient on its own to cause the disease, and a destructive immune-inflammatory response is a key to the translation of risk to destructive events. Ot
This chapter briefly reviews how bibliometric indicators are used for allocating resources in academia. How these measures can be understood in relation to different evaluation systems is discussed, and various types of applications - including individual level use - are outlined. Furthermore, attention is given to the effect of evaluation in terms of incentives and possible adverse effects. The i
Most state-of-the-art satisfiability algorithms today are variants of the DPLL procedure augmented with clause learning. The main bottleneck for such algorithms, other than the obvious one of time, is the amount of memory used, fn the field of proof complexity, the resources of time and memory correspond to the length and space of resolution proofs. There has been a long line of research trying to
Human beings are definitely storytellers capable of travel back and forward in time. We not only construct stories about ourselves, but also share these with others (McAdams and McLean 2013). We construct and internalize an evolving and integrative story for life, that is, a narrative identity (Singer 2004). However, the life story is just one of three layers of personality that are in a dynamical
A push-pull oscillator topology that uses only one type of active device is proposed in this article. A magnetic transformer is leveraged to set positive feedback around a common-collector differential npn transistor pair, implementing the push-pull operation. This results in half the bias current for a given amplitude of oscillation, compared to more standard oscillator topologies. A thorough pha
The misfolding and aberrant aggregation of proteins into fibrillar structures is a key factor in some of the most prevalent human diseases, including diabetes and dementia. Low molecular weight oligomers are thought to be a central factor in the pathology of these diseases, as well as critical intermediates in the fibril formation process, and as such have received much recent attention. Moreover,
Objective: We describe an Iraqi family with two recessive movement disorders, leukoencephalopathy with ataxia caused by CLCN2 mutations (LKPAT) and autosomal recessive spastic paraplegia 56 (SPG56) caused by mutations in CYP2U1. Methods: Members of an Iraqi family underwent structured interviews and neurological examination. Neuroimaging and whole exome sequencing were performed, and medical recor
This paper draws on artistic explorations of territorial and spatial forces through analysis of projects set in the natural landscape, in a specific indoor site or at the threshold between the two. Specific attention is given to the artistic processes at play in the transformation of materials cre- ated/collected in the natural environment when shaped for presentation in an indoor location. What i
Turkey is in search of a new social contract premised on an extensive revision of the country's Kemalist inheritance and incorporating the economic and political transformations set in motion in the Ozal period. This is not a straightforward task for the reformist forces in Turkish politics and civil society; the imperative and nature of reform are the object of contestation between those factions
ScopeAccurate numerical modeling of fluid transport is essential in reservoir management. Higher-order methods help to improve accuracy by reducing the numerical diffusion, which is common for all first order methods. In this paper, we present an implementation of a MUSCL-type second-order finite volume method and demonstrate its capabilities on 2D and 3D unstructured grids. This includes corner p
We ask if mass tourism, morphing into over-tourism, can be conceptualised as an emerging plague of zombie tourists, and what kinds of tourism futures might come of it? Overtourism is not only unsustainable; it is the logical outcome of capitalism and thus, a token signifying that the capitalist system is well and alive even though it is threatening everything else on Earth. We outline a drastic na
Foreign Policies of EU Member States provides a clear and current overview of the motivations and outcomes of EU Member States regarding their foreign policy-making within and beyond the EU. It provides an in-depth analysis of intra-EU policy-making and sheds light, in an innovative and understandable way, on the lesser-known aspects of the inter-EU and extra-EU foreign policies of the twenty-eigh
β-Galactose derivatives have recently been reported to selectively inhibit galectin-3, and a library of O3-arylated galactosides with varying substitution patterns was designed to study such inhibitions further. The O3-arylated galactosides were synthesized using diaryliodonium salts under mild and transition metal free conditions, providing the target products in moderate to good yields. An O3-tr
