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Objective: There is an urgent need for sensitive, widely available, blood-based screening tests to identify presymptomatic individuals destined to develop Alzheimer's disease (AD). We investigated whether tau detected in plasma by our in-house NT1 assay is specifically altered in AD, and when applied to patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) can serve t
The nitric oxide (NO) formation in methane (CH4) flames has been widely investigated, with quite a few kinetic mechanisms available in the literature. However, studies have shown that there are often discrepancies between the simulations using various mechanisms and the experimental results. To elucidate reactions leading to these discrepancies, experiments were designed to measure the NO formatio
Biosynthesis of 3 human granule proteins, myeloperoxidase, defensin and lysozyme, all present in azurophil granules, was investigated in normal bone marrow cells and in the promyelocytic cell line HL-60 to see whether differences in timing of biosynthesis could explain the well established differences in their subcellular localization in the mature neutrophil (targeting), and whether differences e
In the case of a quantum-noise limited detector, signal detection theory suggests that stereoradiographic images can be acquired with one half of the per-image dose needed for a standard radiographic projection, as information from the two stereo images can be combined. Previously, film-screen stereoradiography has been performed using the same per-image dose as in projection radiography, i.e., do
The interactions between protein and surfactants play an important role in the stability and performance of formulated products. Due to the high complexity of such interactions, multi-technique approaches are required to study these systems. Here, an integrative approach is used to investigate the various interactions in a model system composed of human growth hormone and sodium dodecyl sulfate. C
In this paper, a system level model for a polymer electrolyte fuel cell (PEFC) system, which is capable of characterizing transient behavior using the control volume method, is developed. Three different cases based on different mass transfer assumptions in the cathode channel are explicitly discussed, i.e., considering the presence of 1) only oxygen, 2) both oxygen and nitrogen or 3) oxygen as we
Terrestrial ecosystems provide a range of important services to humans, including global and regional climate regulation. These services arise from natural ecosystem functioning as governed by drivers such as climate, atmospheric carbon dioxide mixing ratio, and land-use change. From the perspective of carbon sequestration, numerous studies have assessed trends and projections of the past and futu
Scenarios are a useful tool to help think about and visualise the future and, as such, are utilised by many policymakers and practitioners. Future scenarios have not been used to explore the urban context in much depth, yet have the potential to provide valuable insights into the robustness of decisions being made today in the name of sustainability. As part of a major research project entitled Ur
Objective: A school tobacco policy (STP) commonly is used to reduce smoking among adoles-cents, but the effectiveness of such programs is unclear. We evaluated the impact of an STP on tobacco use in 4 schools. Methods: The study included 4 intervention and 4 control schools, located in the inner city of Stockholm, Sweden. Schools self-selected for assignment to either an intervention program or a
Antibiotika-resistens utgör ett ökande hälsoproblem i världen och bakterier blir alltmer resistenta mot de antibiotika vi har att behandla med. Fler bakterier blir också resistenta mot mer än ett antibiotikum och behandling av infektioner med dessa typer av bakterier kompliceras av bristen på effektiva läkemedel vilket leder till ökade sjukvårdskostnader, längre vårdtider och en minskad chans att Multi-drug resistant (MDR) infections remain the leading cause of death worldwide. MDR infections caused by Streptococcus pneumoniae (Spn), Streptococcus pyogenes (GAS) and Streptococcus agalactiae (GBS) are considered global threats to human health due to increased spread of antibiotic resistance and limited treatment options. In this thesis, we present the human milk derived HAMLET (Human Alpha-
Socioeconomic development initiatives (SDIs) have become a controversial issue. In giving skill trainings and credit supports, practitioners assume that SDI participation will enhance women’s income/dignity. Some studies have indicated that SDIs reduce women’s exposure to marital violence (MV), while others have shown that they increase spousal conflicts/MV. Our study explains how SDI participatio
This survey overviews the potential use of cryptographic primitives in the fifth-generation mobile communications system (aka 5G) and beyond. It discusses the new security challenges that come with 5G and presents the upcoming security architecture. It shows the use of current cryptographic algorithms and discusses new algorithms or modifications of existing ones, that can be relevant. It also dis
Spontaneous formation of vesicles from the self-assembly of two specific surfactants, one zwitterionic (oleyl amidopropyl betaine, OAPB) and the other anionic (Aerosol-OT, AOT), is explored in water using small-angle scattering techniques. Two factors were found to be critical in the formation of vesicles: surfactant ratio, as AOT concentrations less than equimolar with OAPB result in cylindrical
BACKGROUND: Injuries were the most common cause of hospitalization in Sweden in 2017. There is a lack of knowledge about trauma recovery and its relation to health-related quality of life (HRQoL) after hospitalization due to minor trauma. This study aimed to prospectively evaluate recovery and HRQoL at discharge from hospital and 3 and 6 months after the trauma. METHODS: This is a secondary analys
The CHEOPS space mission dedicated to exoplanet follow-up was launched in December 2019, equipped with the capacity to perform photometric measurements at the 20 ppm level. As CHEOPS carries out its observations in a broad optical passband, it can provide insights into the reflected light from exoplanets and constrain the short-wavelength thermal emission for the hottest of planets by observing oc
Although folded proteins are commonly depicted as simplistic combinations of β-strands and α-helices, the actual properties and functions of these secondary-structure elements in their native contexts are just partly understood. The principal reason is that the behavior of individual β- and α-elements is obscured by the global folding cooperativity. In this study, we have circumvented this problem
Background: The purpose of this study was to prospectively recruit patients treated with limb malformation and to explore the prevalence and the clinical and epidemiological features of Heart-Hand Syndrome (HHS) in China. Methods: The consecutive patients treated for congenital upper limb malformation in Beijing Ji Shui Tan Hospital from October 1st, 2016 to October 1st, 2019 were prospectively re
With high energy heavy ion collisions one tries to create a new forms of matter that is similar to the one present at the birth of our Universe. Recent development on flow pattern, initial energy-density and freeze-out temperature shows that most likely this new form of matter is in a deconfined state, has colored degrees of freedom and is more fluid-like than gas-like. In present paper we calcula
