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Autoimmune type 1 diabetes is strongly associated with a number of immune abnormalities that manifest themselves before and at the time of clinical diagnosis. The clinical onset is associated with a major loss of the pancreatic islet beta cells. Insulin treatment is the only treatment option since numerous trials with agents that suppress or modulate immune function have failed to preserve beta ce
Background. The aim was to evaluate whether patients with benign ovarian cysts, functional ovarian cysts, or endometriosis have an increased risk of developing gynecologic cancer. Methods. The Swedish Hospital Discharge Register was used to identify a cohort of women discharged from hospital with the diagnoses of ovarian cyst (n = 42 217), functional ovarian cyst (n = 17 998), or endometriosis (n
High-spin states in the proton-rich nucleus V-45 have been identified for the first time. A comprehensive gamma-ray decay scheme has been established following an experiment performed at the Vivitron accelerator at IReS Strasbourg by using the Euroball gamma-ray detector array coupled to the Neutron Wall and Euclides detector arrays. The natural (negative-) parity scheme is identified up to the f(
High-spin states of the nucleus Lu-163 have been populated through the fusion-evaporation reaction La-139(Si-29, 5n) with a beam energy of 157 MeV. In addition to the two lowest excited triaxial strongly deformed (TSD) bands, recently interpreted as one- and two-phonon wobbling excitations, a third excited TSD band has been firmly established decaying to the yrast TSD band. The assignment of this
Cytogenetic investigation of short-term cultures from two leiomyosarcomas revealed complex karyotypic changes in both cases. The first tumor, a subcutaneous leiomyosarcoma of the knee, had the karyotype 70-80,XY, +X, +Y, +1, +1, +2, +2, +3, +3, +4, +4, +7, +7, +8, +8, +9, +10, +15, +15, +16, +16, +18, +19, +20, +21, +21, +22, +22,t(?;5)(5;21)(?;q35p11;q11), t(?;5)(5;21)(?;q35p11;q11), +del(11)(q22
Disorders of the central nervous system are a major concern in modern human societies. Studies of these disorders require the use of suitable model systems that accurately reproduce the human situation. In this article we focus on the possibilities of using the human NT-2 teratocarcinoma cell line for studies on neuronal differentiation, cellular function and neurodegeneration. Neurons generated f
An analysis of siderophores produced by Magnaporthe grisea revealed the presence of one intracellular storage siderophore, ferricrocin, and four coprogen derivatives secreted into the medium under iron depletion. Structural analysis showed that the compounds are coprogen, coprogen B, 2-N-methylcoprogen and 2-N-methylcoprogen B. Siderophore production under low and high iron conditions was quantifi
The BCR gene is implicated in the development of Ph-positive leukemia through its fusion with the nonreceptor tyrosine kinase gene ABL. The normal 160 kDa Bcr protein has several functional domains, and recently one specific role for Bcr was established in the regulation of respiratory burst activity in white blood cells. Bcr expression levels are relatively constant throughout mouse development u
Using the eight-band k center dot p model and the Burt-Foreman envelope function theory to perform self-consistent calculations, we have studied the effect of electron-hole hybridization on the cyclotron masses m(*) and the effective g-factors g(*) of two-dimensional quasiparticles in InAs/GaSb quantum wells under a magnetic field applied perpendicular to the interfaces. We can modify the degree o
Non-covalently molecularly imprinted polymers (MIPs) for beta(2)-amino acids were prepared for the first time. N-(2-chlorobenzyloxycarbonyl)-(R)-beta(2)-homophenylalanine (N-2-ClZ-(R)-beta(2)-HPhe)was imprinted with methacrylic acid (MAA) and/or 4-vinylpyridine (4-VPy) as the functional monomers, with ethylene glycol dimethacrylate ( EDMA) as the cross-linker. The MIPs made with different ratios o
The ground and the excited state properties of the fullerene-linked quarter-thiophenes dyad were studied theoretically with the quantum chemistry method. To reveal the excited state properties of them in the vertical absorption process, the energies and densities of the HOMO and LUMO, the intramolecular charge transfer (ICT), locally excited (LE) are studied with transition density matrix, charge
A laterally extensive and conspicuously smooth erosional surface is exposed near the Wenlock-Ludlow boundary on east-central Gotland, Sweden. It occurs in the reef complex area of a carbonate platform, has an undulating topography, and separates truncated bioherms and biostromes from overlying allochthonous high energy deposits. On a basin regional scale, the surface is associated to a shift from
Treatment of type 3 von Willebrand disease (vWD) relies on infusion with plasma-derived factor concentrates containing von Willebrand factor (vWF). Patients with types 1 and 2 vWD who do not respond satisfactorily after receiving desmopressin need treatment with concentrates. The rationale for long-term prophylaxis in vWD is obvious: prophylaxis has been successfully used in hemophilia, and joint
Popular Abstract in Swedish Pneumokocker är den vanligaste bakteriella orsaken till öron- och lunginflammation, men kan också orsaka allvarliga och livshotande infektioner som hjärnhinneinflammation hos både barn och vuxna. I Sverige är allvarlig pneumokocksjukdom bland äldre fortfarande den vanligaste dödliga infektionssjukdomen med en mortalitet kring 10 %. Tills nyligen kunde alla pneumokockinS. pneumoniae is a major cause of common diseases such as acute otitis media and pneumonia, as well as more serious illnesses like septicemia and meningitis. The increasing level of resistance in pneumococci threatens to change the tradition of treating common respiratory infections with narrow-spectrum penicillin. In the city of Malmö the proportion of penicillin nonsusceptible S. Pneumoniae (PNS
A total of 300 gastric biopsy samples and 50 Helicobacter pylori isolates were collected from Ethiopian adult dyspeptic patients. The vacA and cagA genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among vacA genotypes, the s1/
