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It has been shown that the exposure to airborne particulate matter is one of the most significant environmental risks people face. Since indoor environment is where people spend the majority of time, in order to protect against this risk, the origin of the particles needs to be understood: do they come from indoor, outdoor sources or both? Further, this question needs to be answered separately for
Objective: To describe the development and evaluation of the content and face validity and test-retest reliability of a disease-specific questionnaire that measures patient-reported outcomes and experiences for the Swedish National Diabetes Register for adult patients who have type 1 or type 2 diabetes. Methods: In this methodological study, a questionnaire was developed over four phases using an
The insufficient operational stability of amine transaminases (ATA) constitutes a limiting factor for high productivity in chiral amine synthesis. In this work, we investigated the operational stability of a tetrameric ATA with 92% sequence identity to a Pseudomonas sp. transaminase and compared it to the two commonly used dimeric ATAs from Chromobacterium violaceum and Vibrio fluvialis. In the pr
OBJECTIVE We tested the associations between genetic background and selected environmental exposures with respect to islet autoantibodies and type 1 diabetes. RESEARCH DESIGN AND METHODS Infants with HLA-DR high-risk genotypes were prospectively followed for diabetesrelated autoantibodies. Single nucleotide polymorphisms (SNPs) came from the Illumina ImmunoChip and environmental exposure data were
In two-particle angular correlation measurements, jets give rise to a near-side peak, formed by particles associated to a higher-pT trigger particle. Measurements of these correlations as a function of pseudorapidity (Δη) and azimuthal (Δφ) differences are used to extract the centrality and pT dependence of the shape of the near-side peak in the pT range 1
Proteiner är några av livets beståndsdelar. Komplexa molekyler som förser våra kropparmed både struktur och funktion, bland annat i muskler. De är kedjor av aminosyror,som vartefter de skapas i kroppen ofta veckar sig till en specifik tredimensionell strukturför att kunna utföra den funktion de har optimerats för under evolutionens gång.Uppstår fel i denna process kan felaktiga strukturer, som oftA protein chain often folds into a functional, specific three dimensional structure. Failurein this process can in some cases lead to disease, e.g. the misfolding disease ALS. Themechanisms behind the folding has mostly been studied under dilute conditions. However,in the natural cellular environment of proteins, the concentration of macromolecules is highand it is believed that this affects vari
Background: The study focuses on three questions related to the clinical usefulness of microdialysis in severe brain trauma: (1) How frequently is disturbed cerebral energy metabolism observed in various types of lesions? (2) How often does the biochemical pattern indicate cerebral ischaemia and mitochondrial dysfunction? (3) How do these patterns relate to mortality? Method: The study includes 21
Evolutionary economic geographers propose that regional diversification is a path-dependent process whereby industries grow out of pre-existing industrial structures through technologically related localised knowledge spillovers and learning. This article examines whether this also applies to emerging radical technologies that create the foundation for new industries. The article develops a new me
Background: Previous studies regarding the association between serum 25-hydroxyvitamin D (25OHD3) and breast cancer risk have not been conclusive. The aim of this study was to investigate the potential association between pre-diagnostic serum 25OHD3 levels and the risk of different subtypes of breast cancer. Materials and methods: The study was based on The Malmö Diet and Cancer Study recruiting 1
Today’s architecture swarms with concepts of energy and resource efficient buildings. In contrast, vernacular buildings are characterized by low-tech climatic responsive strategies and by their inhabitants’ resource and energy savings practices during construction and operation of their dwellings. That makes vernacular buildings highly relevant to resource efficiency in contemporary building resea
Hypothalamic pathology, metabolic dysfunction and psychiatric symptoms are part of Huntington disease (HD), which is caused by an expanded CAG repeat in the huntingtin (HTT) gene. Inactivation of mutant HTT selectively in the hypothalamus prevents the development of metabolic dysfunction and depressive-like behavior in the BACHD mouse model. The hypothalamic paraventricular nucleus (PVN) is implic
OBJECTIVES: To study attitudes regarding possible inheritance of prostate cancer among sons of men with prostate cancer.METHODS: A questionnaire was sent to 69 men with prostate cancer and their 101 unaffected sons. All participants were also interviewed by telephone. Sociodemographic data were collected, as were data about the fathers' disease.RESULTS: The response rate was high; 100 sons (99%) a
During the last thirty years, the Evangelical relationship with the State of Israel has drawn much academic and popular attention, particularly from historical, theological, and political perspectives. This dissertation engages with this literature but also complements it with an ethnographic account of the discursive practices of Evangelical Zionists through which, it is suggested, much of the re
A brief period of sublethal ischemia induces resistance to a subsequent, otherwise lethal, ischemic insult, a process named ischemic tolerance or preconditioning. A persistently disturbed cell signaling during reperfusion after cerebral ischemia has been proposed to contribute to ischemic cell death. Here, we report on the effect of ischemic preconditioning on the levels of the regulatory α-subuni
Rodent models of L-DOPA-induced dyskinesia (LID) are essential to investigate pathophysiological mechanisms and treatment options. Ratings of abnormal involuntary movements (AIMs) are used to capture both qualitative and quantitative features of dyskinetic behaviors. Thus far, validated rating scales for the mouse have anchored the definition of severity to the time during which AIMs are present.
Aim: To determine the importance of different biogeographical processes (vicariance, dispersal, long-distance dispersal and establishment or LDDE) for the current distribution of metalmark moths, a group of small insects, using a time-calibrated molecular tree. Location: Global. Methods: We sampled 104 species of metalmark moths with representatives from all six major biogeographical regions of th
The Cone Calorimeter test method has been for years one of the most used small-scale fire test methods. It is certainly one of the methods which is most widely spread over the world at this moment. In contrast to many other fire test methods, the Cone Calorimeter provides a range of data with sound scientific basis, which allows a wide range of applications. In this article five different areas of
1. The amino acid l-3,4-dihydroxyphenylalanine (l-DOPA) was extracted from tentacles of the sea anemone Metridium senile and from brains of the crayfish Pacifastacus leniuscuius.2. The identity of l-DOPA was ascertained by gas chromatography-mass spectrometry as the heptafluorobutyryl iso-butyl ester derivative. Dopa is identified with GC-MS for the first time and the derivatization is a novel mod
Atomic spectral lines from different isotopes display a small shift in energy, commonly referred to as the line isotope shift. One of the components of the isotope shift is the field shift, which depends on the extent and the shape of the nuclear charge density distribution. The purpose of this work is to investigate how sensitive field shifts are with respect to variations in the nuclear size and
