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Introduction: TH2-upstream cytokines (IL-33, IL-25 and TSLP) have emerged as key cytokines in the promotion of allergic asthma. Macrophages (Mϕs) play an important role in the pathogenesis of asthma both in the inflammatory and resolution phases of the disease. Mϕs can acquire different phenotypes depending on their microenvironment. Our aim was to investigate the difference in expression of TH2-u
Skyldigheten att skydda, eller “R2P”, är en princip som har skapat vild debatt sedan den först introducerades av the International Commission on Intervention and State Sovereignty (ICISS) år 2001. Efter den positiva respons begreppet fick av FN:s medlemsstater under the World Summit Outcome 2005 verkade det som att FN rörde sig mot en ny tidsperiod, där arbetet för mänskliga rättigheter även skull
Managing the impacts of land use change on ecosystem services is essential to secure human wellbeing; but is a task often complicated by landscape-scale spatial dynamics. In this study, we focus on one type of spatial dynamic: multi-site interactions (MSI), which we define to occur when a change in the supply or use of an ecosystem service at one site affects that service at a second site. In sear
The atmospheres of ultra-hot Jupiters are highly interesting and unique chemical laboratories. Due to the very high atmospheric temperatures, their chemical composition is dominated by atoms and ions instead of molecules, and the formation of aerosols on their day-sides is unlikely. Thus, for these planets detailed chemical characterisations via the direct detection of elements through high-resolu
The saints’ Lives written by Kyrillos (Cyril) of Skythopolis form a centrepiece in Greek hagiography, not least through the two central Lives of Euthymios and Sabas, respectively. The occurrence of lions in the Kyrillos’ narrative has been noted before, but not with respect to their eschatological and symbolic function, especially in attaching the performance of the saints to landscape and wildern
Background Colon cancer incidence is rising globally, and factors pertaining to urbanization have been proposed involved in this development. Traffic noise may increase colon cancer risk by causing sleep disturbance and stress, thereby inducing known colon cancer risk-factors, e.g. obesity, diabetes, physical inactivity, and alcohol consumption, but few studies have examined this. Objectives The o
Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to map potential functional variants in the haplotype block tagged by rs1885988 and used CRISPR-Cas9 to edit the potential functional variants to confirm
The plant defence proteins α1- and α2-purothionin (Pth) are type 1 thionins from common wheat (Triticum aestivum). These highly homologous proteins possess characteristics common amongst antimicrobial peptides and proteins, that is, cationic charge, amphiphilicity and hydrophobicity. Both α1- and α2-Pth possess the same net charge, but differ in relative hydrophobicity as determined by C18 reverse
The current way of consumption and production is unsustainable in that society is exceeding the earth’s planetary boundaries and creating long-term and irreversible effects on an environmental, social, and economic level. There is a recognized need on all system levels to change the way that we operate. Industry is a key area that requires this attention, as it is largely responsible for the impac
Objectives of this paper are to propose a reasonable simulation model that can handle condensation and frost formation in heat exchangers dependent on moisture concentration and outdoor climate conditions, and to analyze risk of frost formation and discuss different frost protection strategies. Using psychometrics, American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE)
IntroductionNational and regional carbapenemase-producing Enterobacterales (CPE) surveillance is essential to understand the burden of antimicrobial resistance, elucidate outbreaks, and develop infection-control or antimicrobial-treatment recommendations.AimThis study aimed to describe CPE and their epidemiology in Norway from 2015 to 2021.MethodsA nationwide, population-based observational study
The Dark Factor of Personality (D) measures the latent core of antagonistic traits. The present study evaluated the psychometric properties of the Swedish version of the full (D70) and the brief (D16) versions, concerning structural validity, item information, and convergent validity. An online sample (N = 294) was analyzed using CFA (Maximum Likelihood Estimation), IRT (Graded Response Model) and
This article brings together the fields of Cold War studies and memory studies.In Denmark, a remarkable institutionalisation of Cold War memory has takenplace in the midst of a heated ideological battle over the past and whether toremember the Cold War as a “war”. Using Danish Cold War museums andheritage sites as case studies, this article sheds new light on the politics of historyinvolved in Col
BACKGROUND: The 2020 European Society of Cardiology (ESC) guidelines recommend using the 0/1-hour and 0/2-hour algorithms over the 0/3-hour algorithm as the first and second choices of high-sensitivity cardiac troponin (hs-cTn)-based strategies for triage of patients with suspected acute myocardial infarction (AMI).PURPOSE: To evaluate the diagnostic accuracies of the ESC 0/1-hour, 0/2-hour, and 0
