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The spectrum argument purports to show that the better-than relation is not transitive, and consequently that orthodox value theory is built on dubious foundations. The argument works by constructing a sequence of increasingly less painful but more drawn-out experiences, such that each experience in the spectrum is worse than the previous one, yet the final experience is better than the experience
Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen organization. Tissue microarrays derived from two cohorts of patients with breast cancer (n=122 and n=498) were immunostained, revealing varying expression of COMP, both in the tumor cells and surrounding stroma. High levels of COMP in tumor cells correlated, independently of
We develop a behavioural framework of bounded rational decision-making under uncertainty to analyse the role of technological dynamism in the firm’s environment for its decision to internationalise innovation. Applying prospect theory, we argue that technological uncertainty in the firm’s environment affects its risk preferences differently depending on its technological capabilities. A key predic
The rejection of forward jets originating from additional proton–proton interactions (pile-up) is crucial for a variety of physics analyses at the LHC, including Standard Model measurements and searches for physics beyond the Standard Model. The identification of such jets is challenging due to the lack of track and vertex information in the pseudorapidity range | η| > 2.5. This paper presents a n
Although differentiated cells normally retain cell-type-specific gene expression patterns throughout their lifetime, cell identity can sometimes be modified or reversed in vivo by transdifferentiation, or experimentally through cell fusion or by nuclear transfer. To examine the epigenetic changes that are required for the dominant conversion of lymphocytes to muscle, we generated heterokaryons bet
Ribs are often employed in internal cooling passages of turbine blades to augment heat transfer with cooling air flowing through the internal ribbed passages. The present work concentrates on truncated ribs to improve thermal performances with continuous ribs in a high aspect ratio channel. With various truncation types and arrangements of truncated ribs, the optimized thermal performance of ribbe
Aims/hypothesis: There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data integration to determine the validity of published evidence. Methods: We (1) buil
De flesta vattenlevande organismer på Jorden lever i en miljö där de samtidigt måste hantera flera olika hot och stressituationer, såsom t.ex. predation, klimatförändringar och brunifiering. Trots relativt god kunskap om varje stressfaktor för sig, vet man förvånansvärt lite om hur synergier av samtidigt förekommande hot påverkar organismer. Därför har jag i min avhandling undersökt hur predation,Most organisms on Earth live in an environment where they are exposed to multiple pressures, including predation and climate change. In many aquatic ecosystems, organisms have to handle additional challenges such as brownification, co-occurring with climate warming. Despite the growing recognition of impacts of climate warming or brownification on the freshwater communities, little is known on how
The oncogenic D816V mutation of the KIT receptor is well characterized in systemic mastocytosis and acute myeloid leukemia. Although KITD816V has been found in melanoma, its function and involvement in this malignancy is not understood. Here we show that KITD816V induces tyrosine phosphorylation of MITF through a triple protein complex formation between KIT, MITF, and SRC family kinases. In turn,
Genome-wide association studies have linked lung cancer risk with a region of chromosome 15q25.1 containing CHRNA3, CHRNA5 and CHRNB4 encoding α3, α5 and β4 subunits of nicotinic acetylcholine receptors (nAChR), respectively. One of the strongest associations was observed for a non-silent single-nucleotide polymorphism at codon 398 in CHRNA5. Here, we have used pharmacological (antagonists) or gen
Aim: To describe initiation and extent of parents' application of skin-to-skin care (SSC) with their preterm infants at two Swedish neonatal intensive care units. Methods: The duration of SSC was recorded in 104 infants' medical charts during their hospital stay, and the parents answered a questionnaire. Results: Both parents were involved in the practice of SSC. Three infants experienced SSC dire
Kangaroo Mother Care (KMC) supports parents' role at the neonatal intensive care unit (NICU). To enhance parents' provision of KMC, it is essential to obtain knowledge of what parents perceive as supportive factors and barriers regarding their opportunities to perform KMC. Aim: To identify factors that parents of preterm infants perceived as supportive factors or barriers for their performance of
Objective: intimate partner violence is a significant health problem. Fear of retaliation and shame may prevent women from telling anyone about the violence. This study investigated the prevalence of disclosure and police reporting of intimate partner violence during the first year postpartum. Design: a prospective longitudinal Swedish cohort study based on information from 2563 women who answered
