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Understanding of mononuclear phagocyte (MNP) diversity in the human intestine and the alterations this compartment undergoes in inflammation remains incomplete. Here, we used single-cell RNA sequencing, cellular indexing of trancriptomes and epitopes by sequencing, flow cytometry, and imaging to explore MNP heterogeneity in human ileal and colonic laminae propriae (LPs) in health and Crohn's disea
Background: Air pollution has been linked to breast cancer risk, but previous studies have seldom considered specific exposure windows, like pregnancy. During pregnancy the breast undergoes substantial changes and exposures may have a stronger impact than if they occurred during other time periods. This study aims to identify associations between ambient air pollution exposure during pregnancy and
A semi-empirical method inspired by Blomqvist's (1969) previous calculations of the excitation energy of the lowest 9/2- state of 201Tl is applied to similar calculations in different Tl, Au and Ir isotopes. These semi-empirical estimates agree well with the experimental values of the excitation energies as well as with the energy differences deduced from the analysis of the total potential energy
The reanalysis of all the experimental data on 225Ra demonstrates the coexistence of reflection asymmetry and reflection symmetry in this nucleus. In 225Ra as well as 227Ra and 229Th this phenomenon can be explained by the calculated ability of the odd particle in different orbitals to polarise the soft nuclear shapes toward smaller and larger octupole deformations.
This article analyses the role of material culture in the enforcing of a colonial order in early modern Sápmi (Land of the Sámi, the indigenous people in northern Norway, Sweden, Finland and the Kola Peninsula in Russia). In addition, the article focuses on the unequal power relations created through the collecting and cultural appropriation of Sámi objects. The 17th century saw a rapid growth of
Direct laser writing (DLW) has arise interest in a variety of fields due to the capabilities that we get from the realization of 2D and 3D structures with high resolution fabrication techniques. Multi-photon lithography (MPL) relies on non-linear absorption effects, making possible the fabrication of metasurfaces with feature size beyond the diffraction limit. A new approach in this direction is t
Carbon Fibre-Reinforced Polymers (CFRP) are a fast growing market of high performance materials and components. Thermally induced damage during machining processes such as drilling or routing are among the limiting factors for product quality, yet accurate temperature measurement remains challenging. This study develops a methodology which combines machinable thermocouples and IR thermometry techn
Transformative neuropathology is redefining human brain research by integrating foundational descriptive pathology with advanced methodologies. These approaches, spanning multi-omics studies and machine learning applications, will drive discovery for the identification of biomarkers, therapeutic targets, and complex disease patterns through comprehensive analyses of postmortem human brain tissue.
Numerous studies have investigated microbial adaptation to increasing soil temperature, but limitations in experimental design hinder comprehensive understanding. These include short-term laboratory studies with constant environmental conditions and field studies with few distinct temperature treatments. Here, we utilized a long-term natural soil geothermal gradient in Aotearoa, New Zealand, rangi
Clinical tools to guide treatment decisions in relapsed/refractory mantle cell lymphoma (R/R MCL) are limited. Moreover, the translational potential of circulating tumor DNA (ctDNA) remains largely unproven. We designed and applied panel-based duplex sequencing of ctDNA to study molecular determinants of response and outcome in 58 patients with R/R MCL treated with venetoclax, lenalidomide, and ri
We study the impact of the early gender environment on inequality in the labor market. To this end, we link primary school data to occupations and earnings. We find that women exposed to more girls at critical ages earn more later on: A 10 percent increase in the share of girls leads to a gender wage gap reduction of 2.7 percent. We explore mechanisms and find a strong selection of women into less
Carbon Black (CB), graphene, and nanodiamond are distinct carbonaceous insoluble nanoparticles. Reactive Oxygen Species (ROS) associated with these particles play a significant role in both in vivo and in vitro toxicity evaluations. Accurate assessment of ROS activity is relevant for toxicity screening and in ensuring safe working environments as well as guiding the innovation by safe-and-sustaina
This report has been prepared with funding from the Nordic Council of Ministers by experts at HEUNI, Fafo and Lund university. The report is a response to a call by the Nordic Work Environment Committee in early 2024 seeking research on the relationship between labour market crime and work environment risks, with the aim of generating more knowledge and practical recommendations and solutions. The
The technical development, involving digitalization, artificial intelligence, automation, and machine learning, can challenge the current tax system and consequently the means to finance public sector activities in several ways. If technology replaces labor, a tax base that is taxed relatively hard will be replaced by a tax base (capital) that generates less tax revenue, and consequently, less tot
BACKGROUND: Long-term prospective data on antibody and T-cell responses beyond the third COVID-19 mRNA vaccine dose, particularly in relation to prior SARS-CoV-2 infections and breakthrough infections, remain limited.METHODS: Health care workers (HCWs) vaccinated with BNT162b2 were enrolled in January 2021. Blood samples were collected before and one month after each of four vaccine doses through
With the increasing prevalence of microplastics (MPs) and nanoplastics (NPs) in global aquatic environments, their potential ecotoxicological and health impacts have become a major concern in environmental science. Slow sand filtration (SSF) is widely recognized for its low energy demand, ecological compatibility, and operational stability; however, its efficiency in removing small or neutrally bu
