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Well-characterized archival formalin-fixed paraffin-embedded (FFPE) tissues are of much value for prospective biomarker discovery studies, and protocols that offer high throughput and good reproducibility are essential in proteomics. Therefore, we implemented efficient paraffin removal and protein extraction from FFPE tissues followed by an optimized two-enzyme digestion using suspension trapping
Subarctic forest-tundra ecotones dominated by mountain birch (Betula pubescens ssp. czerepanovii) are an important habitat for semi-domestic reindeer Rangifer tarandus. The seasonal timing of reindeer grazing may direct vegetation trajectories in these systems, because in the summer ranges, mountain birches are subjected to browsing, while in the winter ranges, reindeer feed on understorey vegetat
Preterm human neonates, contrary to preterm piglets, obtain immunoglobulins from their mothers via the placenta during intrauterine development. However, one should note that the majority of trans-placental transfer of immunoglobulins in humans takes place during the last trimester of pregnancy. It is also known that the feeding of limited amounts of colostrum or systemic infusion of small amounts
We have studied the presence of novel inflammatory markers as soluble urokinase plasminogen activator receptor (suPAR) and natural IgM antibodies directed against phosphorylcholine (αPC-IgM) in Swedish diabetic patients (n = 164) and in healthy control subjects (n = 41). SuPAR is expressed by several types of immune cells and has been shown to be a marker of disease severity and predict mortality
The development of bleomycin-induced pulmonary fibrosis in rats was studied over a period of 21 d after an intratracheal instillation of bleomycin. The expression of three small proteoglycans (biglycan, decorin, and fibromodulin), collagen III and TGF-beta 1 was studied by RNA-transfer blot analysis. The proteoglycans were also studied by SDS-polyacrylamide gel electrophoresis and Western blots. T
Increasing sickness absence rates among care and service employees in Sweden motivate health-promoting activities. It is crucial to employers and key stakeholders, like HRM departments, to have knowledge of resources related to employees' work life balance (WLB) to increase well-being at work. The aim of the study was to explore resources associated with WLB, with focus on work and private lives a
In this work the cutting tool temperature distribution that develops during turning of hardened cold-work tool steel is modeled on the basis of experimental data. The data obtained from a series of thermocouples, placed on a PCBN insert, into an anvil, and into a toolholder, were used as the input for the model. An inverse problem was solved, where the heat fluxes were computed. The temperature di
The common practice of using general concepts as tools in legal reasoning is bound to raise questions concerning the relative importance of the general and the specific for the understanding of international law. To illustrate, this article uses two judgments handed down by the icty Trial Chamber. While for both judgments, the Chamber inferred from human rights instruments an alleged general conce
Factor V (FV) is a regulator of both pro- and anticoagulant pathways. It circulates as a single-chain procofactor, which is activated by thrombin or FXa to FVa that serves as cofactor for FXa in prothrombin activation. The cofactor function of FVa is regulated by activated protein C (APC) and protein S. FV can also function as an anticoagulant APC cofactor in the inhibition of FVIIIa in the membra
Eco-efficient Value Creation is a method to analyse innovative product and service design together with circular business strategies. The method is based on combined analyses of the costs, market value (perceived customer value) and eco-costs. This provides a prevention-based single indicator for ‘external environmental costs’ in LCA. The remanufacturing of products is an environmental and sustain
Background: Restrictive eating problems are rare in children but overrepresented in those with neurodevelopmental problems. Comorbidities decrease wellbeing in affected individuals but research in the area is relatively scarce. This study describes phenotypes, regarding psychiatric and gastrointestinal comorbidities, in children with restrictive eating problems. Methods: A parental telephone inter
Flow field design of fuel cells has a significant impact on the distribution of the reactants over the active surface area. In this work, the cell performance and transport characteristics of high temperature proton exchange membrane fuel cells with metal foams as flow distributor were numerically investigated by a three-dimensional and non-isothermal model. Compared to the fuel cell with conventi
På flera platser i Södra Sverige avlägsnas dynvegetation från sanddyner utmed kusten för att öka biodiversiteten i sandiga miljöer. På dessa platser sker även morfologiska förändringar, eftersom dynerna inte längre stabiliseras av vegetationen. I den här fallstudien utvärderas effekten av vegetationsborttagning på dynerosion från vind och vågor. Analys av volym- och arktäckningsförändringar visarAt several places in South Sweden, dune vegetation is removed from coastal dunes with the purpose to increase biodiversity in sandy habitats. At these sites, also morphological changes take place as the dunes are no longer stabilized by vegetation. In this case study at Ängelholm Beach in South Sweden, the effect of vegetation removal on dune erosion by wind and waves is evaluated. Analyses of vol
AIMS/INTRODUCTION: A prolonged QT interval plays a causal role in life-threatening arrhythmia and becomes a risk factor for sudden cardiac death. Here, we assessed the association between microvascular complications and the QT interval in patients with type 2 diabetes.MATERIALS AND METHODS: Patients with type 2 diabetes (n = 219) admitted to our hospital for glycemic control were enrolled. QT inte
The light pulses of a mode-locked Ar+ laser have been synchronized to the synchrotron radiation pulses of the SuperACO storage ring in Orsay. In order to test the feasibility and to demonstrate the capability for the investigation of free atoms we have studied the two-photon ionization of atomic Helium and Xenon via the He* 1s3p and Xe* 5p55d resonant state, respectively. The experimental results
Purpose: The objective was to assess the reliability level of mini-plate fixation used in fracture mandibles in order to evaluate the structure stability in both convalescence and healing periods. Methods: In the convalescence period, the failure scenario is measured by the relative displacement between two fracture surfaces which should not exceed an acceptable value in order to obtain a good sta
Background: Adolescent anxiety and depression are highly prevalent psychiatric disorders that are associated with altered molecular and neurocircuit profiles. Recently, increased mitochondrial DNA copy number (mtDNA-cn) has been found to be associated with several psychopathologies in adults, especially anxiety and depression. The associations between mtDNA-cn and anxiety and depression have not,
Objective: Diabetic foot ulceration (DFU) has the potential to deteriorate rapidly without prompt assessment and treatment. The aim of this study was to assess the referral patterns for DFU, from primary care to specialised diabetes foot care units. Method: A two-part, quantitative, online questionnaire was administered to GPs across four countries in Europe: France, the UK, Germany and Spain. The
