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Recent studies indicate that mitochondrial DNA (mtDNA) dysfunction is a biomarker of oxidative stress and can predict the risk of cardiovascular diseases (CVDs). Genetic variants in PARK2 (rs4708928) and MRPL37 (rs10888838) genes have been shown to be associated with altered levels of mtDNA in a sex-specific manner. However, the role of these genetic variants in risk assessment of recurrent venous
We investigate the population of high-redshift (3≤z < 6) active galactic nuclei (AGN) selected in the two deepest X-ray surveys, the 7 Ms Chandra Deep Field-South and 2 Ms Chandra Deep Field-North. Their outstanding sensitivity and spectral characterization of faint sources allow us to focus on the sub-L* regime (logLX ≲ 44), poorly sampled by previous works using shallower data, and the obscured
Introduction On June 11, 2014, the International Labour Organization (ILO) adopted a new Protocol to its Forced Labour Convention, 1930 (No. 29) (ILO 1930), and a new Recommendation to supplement and develop both Convention No. 29 and the Protocol. These new ILO standards do not affect the definition of trafficking or the vital role of the UN Office on Drugs and Crime (UNODC) in leading the fight
Timing and indication for pulmonary valve replacement (PVR) in patients with repaired Tetralogy of Fallot (rToF) and pulmonary regurgitation (PR) are uncertain. To improve understanding of pumping mechanics, we investigated atrioventricular coupling before and after surgical PVR. Cardiovascular magnetic resonance (CMR) were performed in patients (n=12) with rToF and PR>35% before and after PVR and
The wear of metal cutting tools is known to take place by the combined and simultaneous effects of several wear mechanisms. Knowledge of the relative contribution of the individual wear mechanisms is required to understand and predict the tool wear during cutting different workpiece materials and alloys. It has been shown previously that machining two heat resistant superalloys, alloy 718 and Wasp
Background: Analysis of sialic acid (SA) metabolites in cerebrospinal fluid (CSF) is important for clinical diagnosis. In the present study, a high-performance liquid chromatography-tandem mass spectrometry (HPLC/MS/MS) method for free sialic acid (FSA) and total sialic acid (TSA) in human CSF was validated. Methods: The method utilized a simple sample-preparation procedure of protein precipitatio
Background: National guidelines are important instruments in reducing inappropriate antibiotic prescriptions. Low adherence to guidelines is an acknowledged problem that needs to be addressed. Method: We evaluated established characteristics for guidelines in the guidelines for lower respiratory tract infection, acute otitis media and pharyngotonsillitis in primary care. We studied how doctors use
BACKGROUND: Sarcopenia increases as renal function declines and is associated with higher morbidity and mortality. Myostatin is a negative regulator of muscle growth. Its expression in response to exercise is unclear. In this prespecified substudy of the Renal Exercise (RENEXC) trial, we investigated the effects of 12 months of exercise training on sarcopenia, muscle mass and plasma myostatin and
The aim of this study was to investigate the risk of developing preeclampsia (PE) associated with gestational exposure to ambient air pollutants in southern Sweden, a low-exposure area. We used a cohort of 43,688 singleton pregnancies and monthly mean exposure levels of black carbon (BC), local and total particulate matter (PM2.5 and PM10), and NOX at the maternal residential address estimated by
Background: Sentinel lymph node biopsy (SLNB) is an important staging tool for the management of melanoma. A multicentre study was done to validate previous findings that the timing of lymphoscintigraphy influences the accuracy of SLNB and patient outcomes, particularly survival. Methods: Data were reviewed on patients undergoing SLNB for melanoma at three centres in the UK and Sweden, examining t
A new parameterization for calculating the nonlinear near-bed wave orbital velocity in the shallow water was presented. The equations proposed by Isobe and Horikawa (1982) were modified in order to achieve more accurate predictions of the peak orbital velocities. Based on field data from Egmond Beach in the Netherlands, the correction coefficient and maximum skewness were determined as functions o
An extraordinarily diverse and well-preserved material, including the remains of 47 insect taxa and 12 taxa of other invertebrates, extracted from the 17th century burial of Bishop Peder Winstrup in Lund Minster, is presented and discussed in terms of the treatment of the body, activities connected with the burial and faunal significance. The invertebrate assemblages include species from gardens,
Viable city logistics are built on a sound business model that considers the financial viability and performance, and the role of externalities and stakeholders. To this end, the purpose of this dissertation is to increase understanding of how a business model can contribute to achieving viable city logistics initiatives.The research presented is qualitative and consists of three studies and five
Pre-school age (3–5 years) children are vulnerable to malnutrition due to poor dietary intake, dietary habits, and socio-economic conditions. Children from marginalized families are more vulnerable than non-marginalized families due to limited access to health- and nutrition-related services, besides other socio-economic factors. This study was done to assess the dietary intakes, patterns, and det
Groundwater (GW) resources provide a large share of the world's water demand for various sections such as agriculture, industry, and drinking water. Particularly in the arid and semi-arid regions, with surface water scarcity and high evaporation, GW is a valuable commodity. Yet, GW data are often incomplete or nonexistent. Therefore, it is a challenge to achieve a GW potential assessment. In this
Precipitation extremes and their underlying causes are important processes to understand to plan appropriate adaptation measures. This paper presents an analysis of the spatiotemporal variability and trend of precipitation extremes in the important source region of the Yellow River and explores the connection to global teleconnection patterns and the 850-mb vector wind. Six indices for precipitati
