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Mollisianitrile (1), a new antibiotic was isolated from the fermentation broth of Mollisa sp. A59-96 together with the two known isocoumarins 2 and 3. 1 exhibited antimicrobial, cytotoxic, and phytotoxic activities. 1 contains a reactive propiolonitrile moiety which is believed to be responsible for its antibiotic activities. Upon incubation with L-cysteine the biological activity was lost.

The homolytic Co-C bond dissociation energy (BDE) is central to the understanding of the function of vitamin B12, an important coenzyme of many proteins. We investigate why earlier density functional (B3LYP) estimations of the BDE in methylcobalamin have given so poor results (91-117 kJ/mol) compared to the experimental estimate (155 ± 13 kJ/mol). Improving the basis set increases the discrepancy,

Understanding how sensory information is used by motor systems for motor commands requires detailed knowledge about how the body shape and biomechanics are represented in the motor circuits. We have used the withdrawal reflex system as a model for studies of sensorimotor transformation. This system has a modular organisation in the adult. Each module performs a detailed and functionally adapted se

The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG. Fifty eight of 283 (4.5%) neonates in tertiary level neonatal intensive care had seizures. The mortality in the infants with neonatal seizures was 36.2%. In 31 survi

The aim of this report is to illustrate how the affected after disasters have experienced their situation and the support from authorities. The study is based on interviews with 16 persons after the storm Gudrun in southern Sweden 2005, the Asian tsunami 2004 and an accident with toxic gas in a Swedish town 2005. The affected received most support, both practical and emotional, from their social

BACKGROUND AND AIMS: Leukocyte recruitment is a key feature in ischemia-reperfusion (I/R)-induced tissue injury. The aim of the present study was to investigate the effect of Rho-kinase inhibition on I/R-provoked leukocyte recruitment in the colon. METHODS: C57BL/6 mice were subjected to 30 min of ischemia by clamping of the superior mesenteric artery followed by 120 min of reperfusion. Intraperit

OBJECTIVES:: Blood flow changes in the intestines during conventional negative pressure wound therapy (NPWT), and NPWT using a protective disc over the intestines in laparostomy. BACKGROUND:: Higher closure rates of the open abdomen have been reported with NPWT compared with other kinds of wound management. However, the method has been associated with increased development of fistulae. We have com

We examined the importance of injury for the epidermal innate immune response in human skin wounds. We found that injury, independent of infiltrating inflammatory cells, generated prominent chemotactic activity toward neutrophils in injured skin because of IL-8 production. Furthermore, injury was a major inducer of the expression of antimicrobial (poly)peptides (AMPs) in skin wounds. In human skin

MMPs are generally considered to regulate degradation and remodeling of the ECM. Convincing data also implicate a role for MMPs in inflammatory conditions, such as AP, although the mechanisms are not known. The aim of this study was to define the role of MMPs in regulating activation of trypsinogen and tissue damage in AP, which was induced by infusion of taurocholate into the pancreatic duct in m

The present study was designed to evaluate yoga's impact on blood pressure (BP) and quality of life (QOL) and on stress, depression and anxiety in patients with hypertension in a primary care setting. We conducted a multi-centre randomized controlled trial with follow-up after 12-week intervention completion. Adult primary care patients diagnosed with hypertension were randomly allocated to yoga o

To estimate incremental costs for patients with psoriasis/psoriatic arthritis (PsO/PsA) compared to population-based referents free from PsO/PsA and estimate costs attributable specifically to PsO/PsA.

OBJECTIVE: The Lundby Study is a prospective longitudinal study of an unselected population consisting of 3,563 subjects. The Lundby Study started in 1947, and follow-ups were carried out in 1957, 1972, and in 1997. METHOD: In all four surveys, semistructured interviews were performed by psychiatrists. Registers, key informants, and case notes from hospitals and outpatient clinics supplemented the

Rationale, aims and objectives The aim of this study was to compare acute hospital utilization and costs for patients with refractory angina pectoris undergoing spinal cord stimulation (SCS) versus enhanced external counterpulsation (EECP). Method Seventy-three persons were included in this register study. The acute hospital utilization and costs for SCS and EECP were followed over a period from 1

BACKGROUND: Knowledge of the size and location of ischemic myocardium during acute coronary occlusion could provide decision support before reperfusion therapy. Electrocardiogram (ECG) scores based on the number of leads and the sum of ST-segment elevation have been unreliable in quantifying ischemia. We aimed to develop a new method to graphically display ischemic myocardium from simulated ECGs (

Accurate prosthesis classification is critical for total joint arthroplasty surveillance and assessment of comparative effectiveness. Historically, prosthesis classification was based solely on the names of the prosthesis manufacturers. As a result, prosthesis designs changed without corresponding name changes, and other prostheses' names changed over time without substantial design modifications.

The aim of this study was to investigate perceived and ideal body image (BI) and associated factors among female university students in Saudi Arabia.

Transplants of fetal dopamine neurons can be used to restore dopamine neurotransmission in animal models of Parkinson's disease, as well as in patients with advanced Parkinson's disease. In these studies the cells are placed in the striatum rather than in the substantia nigra where they normally reside, which may limit their ability to achieve full restoration of motor function. Using a microtrans

Objective Our aim was to study depression and anxiety in atrial fibrillation (AF) patients as risk factors for all-cause mortality in a primary care setting. Methods The study population included adults (n = 12 283) of 45 years and older diagnosed with AF in 75 primary care centres in Sweden. The association between depression or anxiety and all-cause mortality was explored using Cox regression an

Incomplete healing of uterine scar after cesarean has been associated with adverse gynecological and obstetrical outcomes. Several studies reported that uterine closure at cesarean influence the healing of uterine scar and the risk of uterine rupture at subsequent pregnancies: the commonly used locked single-layer suture including the decidua being associated with a four-fold increase risk of uter