Filtyp
PURPOSE: Predictive strategies for the treatment efficacy of cetuximab are currently not available for head and neck cancer. We investigated the correlation between the expression of epidermal growth factor receptor (EGFR) ligands and EGFR expression, and the growth inhibitory activity of cetuximab in a panel of head and neck squamous cell carcinoma (HNSCC) cell lines. METHODS: The growth inhibiti
To describe environmental barriers, accessibility problems, and powered mobility device (PMD) users' autonomy indoors and outdoors; to determine the home environmental barriers that generated the most housing accessibility problems indoors, at entrances, and in the close exterior surroundings; and to examine personal factors and environmental components and their association with indoor and outdoo
The phase behavior of water, diesel, limonene, and ethanol was investigated at ambient temperature using single nonionic alkyl polyglycol ethers (C14E3). Visual inspection as well as crosspolarizers was used to detect transparency and anisotropy. Ternary phase diagrams were determined. Combustion experiments using a four-cylinder diesel engine were carried out. Isotropic water in diesel microemuls
The humoral immune response to human cytomegalovirus (CMV) membrane glycoprotein gp58/116 (gB) has been studied by establishing cell lines producing specific human monoclonal antibodies. These cell lines were generated from peripheral blood lymphocytes obtained from a healthy carrier. Hybridomas producing gp58/116-speciftc antibodies were detected by reactivity to procaryotically expressed protein
OBJECTIVE: To investigate how people with multiple sclerosis (MS) experience their participation in individual, face-to-face cognitive behavioural therapy (CBT) aimed at alleviating depressive symptoms.METHOD: Semistructured interviews with 12 participants were conducted after CBT and analyzed using qualitative content analysis.RESULTS: Two main themes emerged: CBT as a demanding process and confr
This collection gathers the more important instruments dealing with the relationships of business with a range of topics such as labor rights, security issues, environmental protection, anti-corruption, good governance, poverty alleviation and development, which all have important human rights dimensions. The premise for this selection is that business has both responsibilities and opportunities t
Wikipedia has become one of the most popular resources in natural language processing and it is used in quantities of applications. However, Wikipedia requires a substantial pre-processing step before it can be used. For instance, its set of nonstandardized annotations, referred to as the wiki markup, is language-dependent and needs specific parsers from language to language, for English, French,
Twist extrusion is a recently developed method of severe plastic deformation that principally uses torsion to generate high strains in a repeatedly extruded billet, while maintaining a constant cross-section. The method thus results in a deformation gradient across the billet section. To date, the grain refinement behaviour of alloys deformed by twist extrusion have only been investigated qualitat
We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to os
Genome-wide association studies (GWAS) have generated considerable interest in glucokinase regulatory protein (GKRP; gene name GCKR) which is an inhibitor of hepatic glucokinase (GCK), an enzyme that plays a critical role in glucose update and disposal in liver. From the initial discovery of GCKR variants associated with triglyceride and glucose levels through the identification of pleiotropic ass
In 2006 a genetic signal within the gene encoding transcription factor 7-like 2 (TCF7L2) was first reported to be associated with type 2 diabetes. Since then multiple genome-wide association studies have revealed this signal to be among the most strongest associations reported with this disease to date. Furthermore, multiple studies around the world have revealed the global relevance of this locus
Background: Despite the lack of evidence for effectiveness of the Flexible Assertive Community Treatment (Flexible ACT), the model is considered feasible and is well received by mental health professionals. No current studies have adequately examined mental health professional experiences of working with Flexible ACT. Aims: The aim of this study was to explore mental health professional experience
This paper contributes to research on restaurant work, which plays an important role in culinary arts research. The aim of this study was to make visible and elucidate the daily work practices in eight small restaurants in a seasonal tourist destination on the Southeast coast of Sweden. The central methods used were observations and participant observations and interviews, along with an e-mail que
Let N be the number of classes in a population to be estimated. Fix any preassigned error probability 0
Public clouds such as Amazon Web Services (AWS) and Microsoft’s Azure provide excellent capabilities for scalable Web applications and Hadoop-based processing. Recent ad- ditions to public clouds to support connected devices and IoT have the potential to similarly disrupt emerging home- grown and/or proprietary approaches. While early public cloud IoT success stories have focused on smaller-scale
We consider the problem of designing distinguishers and nonrandomness detectors for stream ciphers using the maximum degree monomial test. We construct an improved algorithm to determine the subset of key and IV-bits used in the test. The algorithm is generic, and can be applied to any stream cipher. In addition to this, the algorithm is highly tweakable, and can be adapted depending on the desire
Nuclear structure studies for even-even nuclei in the mass region ∼130, have been performed, with a special focus around N or Z = 64. On the onset of deformation and lying between two closed shell, these nuclei have attracted attention in a number of studies. A revisit to these experimentally accessible nuclei has been made via the relativistic mean field. The role of pairing and density depletion
