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The key reaction of protein synthesis, peptidyl transfer, is catalysed in all living organisms by the ribosome - an advanced and highly efficient molecular machine. During the last decade extensive X-ray crystallographic and NMR studies of the three-dimensional structure of ribosomal proteins, ribosomal RNA components and their complexes with ribosomal proteins, and of several translation factors
We have used the density functional B3LYP method to study the effect of hydrogen bonds from the histidine ligand in various haem proteins to carboxyl groups or to the carbonyl backbone. Hydrogen bonds to carbonyl groups (encountered in globins and cytochromes, for example) have a small influence on the geometry and properties of the haem site. However, hydrogen bonds to a carboxyl group (encounter
In this communication, we analyse the passage of oxygen and carbon dioxide over the respiratory membrane. The lung surfactant membrane at the alveolar interface can have a very special arrangement, which affects the diffusional transport. We present a theoretical model for the diffusion of small molecules in membranes with a complex structure, and we specifically compare a membrane composed of a t
In this article, I will apply parts of the method introduced by Linda Hutcheon in her recently reedited book A Theory of Adaptation (2010) and try to answer the question “why” an adaptation is made. I will particularly study three complex cases of adaptation, which might even put into question the definition of adaptation itself, but I will concentrate on aspects related to immersion and self-refe
Popular Abstract in English N/AAquatic systems worldwide receive large amounts of organic carbon from terrestrial sources. This ‘allochthonous’ organic carbon (AlloOC) affects critical physical and chemical properties of freshwater ecosystems, with consequences for food web structures and exchange of greenhouse gases with the atmosphere. In the boreal region, loadings of AlloOC are particularly high due to leaching from huge or
Enriched environment (EE) housing significantly ameliorates neurological deficits induced by cortical brain ischemia without changing infarction size, suggesting that EE-related functional benefits are associated with neuronal plasticity events in the remaining tissue. Brain-derived neurotrophic factor (BDNF), nerve growth factor-induced gene A (NGFI-A) and corticosteroid receptors (mineralocortic
TB PNA FISH is a new fluorescence in situ hybridization (FISH) method using peptide nucleic acid (PNA) probes for differentiation between species of the Mycobacterium tuberculosis complex (MTC) and nontuberculous mycobacteria (NTM) in acid-fast bacillus-positive (AFB+) cultures is described. The test is based on fluorescein-labelled PNA probes that target the rRNA of MTC or NTM species applied to
The cGMP-dependent protein kinase (PKG) is the main mediator of nitric oxide-induced relaxation of smooth muscle. Although this pathway is well established, the cellular action of PKG, nitric oxide, and cGMP is complex and not fully understood. A cross-talk between the cGMP-PKG and other pathways (e.g. cAMP-protein kinase A) seems to exist. We have explored cGMP- and cAMP-dependent relaxation of s
Cytogenetic analysis was performed on short-term cultures of primary ovarian carcinomas from 62 patients. Cytogenetic analysis was successful in 59 cases. Clonal chromosome aberrations were detected in 35 tumors. Only numerical changes or a single structural change were found in five carcinomas: trisomy 12 was the sole anomaly in two tumors, one tumor had the karyotype 50,XX, + 5, + 7, + 12, + 14,
Popular Abstract in Swedish I avhandlingen studeras plasminogenaktiverings-systemets (PA-systemets) komponenter i livmoderslemhinnan. PA-systemet reglerar omvandlingen av plasminogen till plasmin. Plasminogen är ett inaktivt enzym som finns överallt i kroppsvätskor samt i kroppens olika organ. Aktiveringen katalyseras av aktivatorer, antingen urokinase plasminogen activator (uPA) eller tissue plasThe release of urokinase plasminogen activator (uPA) from endometrial stromal cells decreased after progesterone stimulation, due to upregulation of PA inhibitor 1 (PAI-1) and uPA receptor (uPAR). Subsequently, the uPA:PAI-1 complex was internalized and degraded via uPAR. Predecidual cells in the late secretory phase expressed PAI-1 and uPAR, supporting a specific role for predecidual cells in the
Popular science summary Reductive evolution in fungi? It has been shown that the super kingdoms of Bacteria and Archaea are under the influence of reductive evolution compared to Eukaryotes. Even if the process of reductive evolution is not the predominant mode of evolution amongst Eukaryotes, since the majority of species are not growth optimized, the process may still be present. It has been
Neonikotinoider – ett hot mot bin, andra insekter och den biologiska mångfalden? Neonikotinoider är en grupp av bekämpningsmedel som används flitigt inom dagens jordbruk. På senare tid har detta dock blivit alltmer ifrågasatt. Forskning har nämligen visat att bin kan ta skada och i värsta fall dö när de får i sig neonikotinoider, och vissa menar att det kan finnas ett samband mellan dessa bekämpNeonicotinoids, e.g. clothiandin, imidacloprid and thiamethoxam, is the most used class of insecticides worldwide. However, lately, this group of insecticides has been subject to controversy. Due to the systemic traits of neonicotinoids, the active compound is translocated throughout the whole plant, which provides effective and long-lasting protection against herbivorous pests. On the other hand,
The war in Ukraine has rocked the international security order with a changed threat picture as a fact. The relationship between China, Russia and the West is complex due to that China agrees with Russia in a common adversary; Western democratic values, while having economic interests in continuing exporting their goods to the West. The united West, including its sanctions against Russia, can put
Tillverkning av batterier är en mycket komplex process och det är en process som Saft AB är väl förtrogen med. För att kunna producera det antal batterier Saft AB gör måste de se till att alla led i produktionen håller en viss standard. Detta projekt hade i mål att utveckla ett användarcentrerat, interaktivt verktyg för Saft AB med förmågan att övervaka och analysera data som samlas in av sensorerThe production of batteries is a substantially complex process, and it is a process with which Saft AB is greatly familiarised. In order to produce the number of batteries Saft AB does, they need to ensure that all stages of production adhere to a certain standard. This project’s purpose aimed to develop a user focused, interactive tool for Saft AB with the capability to monitor and analyse the da
Ehlers Danlos syndrom (EDS) är en ovanlig ärftlig sjukdom som bland annat kan ge överrörliga leder, töjbar hud och långvarig smärta. Det finns flera olika typer av EDS och vilka besvär man lider av som patient kan variera mycket. Långvarig smärta utgör dock ett vanligt besvär. Det tar ofta lång tid innan diagnosen ställs och många patienter känner sig missförstådda av vården. Det finns i dagslägetIntroduction - Ehlers Danlos syndrome (EDS) is an uncommon connective tissue disorder. Studies have shown that patients feel misunderstood by physicians but there is limited information about the physicians’ experiences. Aim - The aim of this study is to explore physicians’ experiences regarding the discovery, diagnostic process and contact with individuals with EDS, as well as what physicians b
Digitaliseringen har i stor utsträckning revolutionerat sättet som företagen gör affärer på. Det finns inte längre samma behov av fysiska platser för affärsverksamheter eftersom teknologin har skapat virtuella platser där företag kan sälja både varor och tjänster utan att överhuvudtaget sätta en fot i jurisdiktionen. Emellertid har reglerna om fast driftställe alltsedan 1920-talet präglats av att The digitalisation has largely revolutionized the way companies do business. There is no longer the same need for physical locations for businesses for the reason that technology has created virtual locations where companies can sell both goods and services without even setting foot in the jurisdiction. However, the rules on permanent establishment have, ever since the 1920’s, been characterized b
This master's thesis presents a qualitative analysis of the activity played out by the users in the physical library room. The study focuses users different activities and therefor also some of the activities made by librarians. The aim of this study is to put light on the activity played out by the user of the physical room at the local library. More precisely two smaller library rooms locat
The objective of this study was to investigate potential differences in gender and place of origin on intimate partner violence (IPV) attitudes, self-silencing beliefs, and sexist and feminist measures in a sample of young adults between 18 and 30 years. Furthermore, it examined whether exposure to videos containing either sexist or feminist humour impacted participants’ level of IPV attitudes, se
