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The molecular mechanism behind affinity maturation is the introduction of point mutations in immunoglobulin (Ig) V genes, followed by the selective proliferation of B cells expressing mutants with increased affinity for antigen. An in vitro culture system was developed in which somatic hypermutation of Ig V genes was sustained in primed B cells. Cognate T cell help and cross-linking of the surface
Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline
BACKGROUND: Limited evidence exists to guide the management of patients with liver metastases from squamous cell carcinoma (SCC). The aim of this retrospective multicentre cohort study was to describe patterns of disease recurrence after liver resection/ablation for SCC liver metastases and factors associated with recurrence-free survival (RFS) and overall survival (OS). METHOD: Members of the Eur
An electronic device requires valid control keys to change any usage restriction setting. The device is provided control keys, a secret key, and a signed software object including a batch ID and a hash of the secret key. For each control key, the device generates a cryptographic footprint bound to the device and the secret key. A message authentication code (MAC) of each usage restriction setting
This paper analyzes the adoption of Additive Manufacturing (AM) technologies in Sweden. The dataset consists of a recent and representative sample of Swedish AM users (companies, universities, and research institutes). The authors investigate two questions. Firstly, what are the current applications of AM in Sweden (e.g. Rapid Prototyping (RP), production)? Secondly, what are the factors that can
It is well established that the nutrient and energy requirements of birds increase substantially during moult, but it is not known if these increased demands affect their aerobic capacity. We quantified the absolute aerobic scope of house and Spanish sparrows, Passer domesticus and P. hispaniolensis, respectively, before and during sequential stages of their moult period. The absolute aerobic scop
Literature compilation.Part of the project: “Histories of Philosophy in Global Perspective”. Under the heading "Histories of Philosophy", you will find a compliation of all works on the history of philosophy known to us, sorted by the language of publication. You will also find a list of all works on the global history of philosophy and a collection of works on the theory of the historiography of philosophy. All these d
In this paper, we are concerned with the ethical implications of the distinction between natural reproduction (via sexual intercourse) and reproduction that requires assistance (either medical or social). We argue that the current practice of enforcing regulations on the latter but not on the former means of reproduction is ethically unjustified. It is not defensible to tolerate parental ignorance
Hepatitis B virus (HBV) infection remains a major public health threat in the Middle East and North Africa (MENA). Phylogenetic analysis of HBV can be helpful to study the putative transmission links and patterns of inter-country spread of the virus. The objectives of the current study were to analyze the HBV genotype/sub-genotype (SGT) distribution, reverse transcriptase (RT), and surface (S) gen
Mixtures of epoxy resins in the presence of epoxy hyperbranched polymers (HBP), in the range of 5-15 wt%, were investigated in the cationic photocuring process. No significant differences in rate of polymerization or final epoxy groups conversion were observed. At low concentration, HBP acts as plasticizer and causes a decrease of the glass transition temperature of the epoxy matrix and of the E'
This paper extends the application of Bayesian inference to probability distributions defined in terms of its quantile function. We describe the method of *indirect likelihood* to be used in the Bayesian models with sampling distributions which lack an explicit cumulative distribution function. We provide examples and demonstrate the equivalence of the "quantile-based" (indirect) likelihood to the
The effect of clock skew and duty-cycle on the performance of high-Q N-phase band-pass filters (BPFs) have been examined in this paper. Following a mathematical approach and using the analytical derivations carried out, the effects of such non-idealities as clock skew and duty-cycle error are determined in an N-path filter. It is analytically proved that image signals from all integer multiples of
Lung function is highly dependent on the structure of the lung parenchyma. Remodeling of the alveolar compartment is a central part of the pathology of chronic lung disease such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). Pathological lung remodeling occurs as an interplay between cells and the extracellular matrix (ECM) which in addition to its structu
Hepatic fibrosis is a pathological response to chronic liver injuries such as chronic alcohol consumption, non-alcoholic fatty liver disease (NAFLD) or chronic viral infections. No antifibrotic compound has been approved for liver fibrosis and if the cause of the chronic injury is not solved, fibrosis can progress to cirrhosis. Currently the only treatment for liver cirrhosis is liver transplantat
In this paper we report the results from two small-scale studies on monotone decreasing (negative) quantifying expressions (QEs) and their negative polarity properties. Some approaches to QEs view polarity item licensing and clause polarity (affirmation/denial) as distinct phenomena. Here, we investigate if this distinction holds for monotone decreasing QEs. In two studies (one on English and one
