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Somatostatin (SST) is a peptide hormone active in the regulation of the endocrine system via different somatostatin receptors subtypes. It inhibits the release of multiple secondary peptide hormones, affecting neurotransmission and cell proliferation. SST has a high therapeutic potential in the treatment of disease, such as acromegali, acute pancreatitis and gastroenteropathic endocrine tumors. Ho

Objectives: The aim of this study was to estimate the cost-effectiveness of rituximab in patients not responding adequately to the first tumor necrosis factor (TNF) inhibitor using a model constructed to predict resource consumption and health outcomes in a population-based registry of biological treatments in Southern Sweden (SSATG). Methods: The model was developed as a discrete event simulation

Acute myeloid leukemia (AML) is associated with a poor survival rate, and there is an urgent need for novel and more efficient therapies, ideally targeting AML stem cells that are essential for maintaining the disease. The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on candidate leukemic stem cells in the majority of AML patients, but not on normal hematopoietic stem cell

Objective: The aim of this study was to describe and assess changes in participants' experiences of everyday occupations after nature-based vocational rehabilitation (NBVR), to assess changes regarding symptoms of severe stress and the rate of return to work and possible association with experiencing the occupational value of everyday occupations. Methods: The NBVR was carried out by a transdiscip

Purpose The purpose of this study is to better understand online anonymity in the global file-sharing community in the context of social norms and copyright law. The study describes the respondents in terms of use of Virtual Private Networks (VPNs) or similar services with respect to age, gender, geographical location, as well as analysing the correlation with file-sharing frequencies. Design/me

Although CD4(+) memory T cells reside within secondary lymphoid tissue, the major reservoir of these cells is in the lamina propria of the intestine. In this study, we demonstrate that, in the absence of signals through both OX40 and CD30, CD4(+) T cells are comprehensively depleted from the lamina propria. Deficiency in either CD30 or OX40 alone reduced CD4(+) T cell numbers, however, in mice def

We describe the transmission of hepatitis C virus (HCV) to two patients from a thoracic surgeon who was unaware of his hepatitis C infection. By partial sequencing of the non-structural 5B gene and phylogenetic analysis, the viruses from both patients were found to be closely related to genotype la strain from the surgeon. Two further hepatitis C cases were found in relation to the thoracic clinic

Abstract in UndeterminedEnterprise Systems (ES) are often the largest and most important Information Systems (IS) an organization employs. Most ES are rented or bought as COTS (Commercial Off The Shelf) software. The use of COTS leads to a distinction between the development of the ES software—done by ES software providers, like SAP and Microsoft—and the implementation of ES software in a specific

Popular Abstract in Swedish Digital bildteknik dominerar snart all bildhantering inom alla delar av samhället. Målsättningen med denna avhandling var att utveckla en undersökningsmetod för mätning av knäleden i belastat läge med hjälp av digital bildplatteteknik. Vad är bildplatteteknik? Traditionellt har röntgenbilder framställts med hjälp av fotografisk film. De framkallade bilderna har sedan The overall aim of this study was to develop and evaluate a measurement system for computed radiography (CR) and Picture Archiving and Communication Systems (PACS), permitting measurements of long distances and angles in and between related images. The developed measurement system, which was based on the QUESTOR Precision Radiography (QPR) system, was applied to the weight-bearing knee with specia

This compilation should be viewed as a kind of prolegomena to a history of interpolation. Three letters from Mischa Cotlar, Antoni Zygmund and Olof Thorin from c. 1980 are reproduced. Thorin's letter is given in translation. These letters were written as a reply to an inquiry by the editor/translator. It is remarkable that while Thorin spent his whole professional life as an actuary, neither of hi

Popular Abstract in Swedish Språklig bearbetning och kontextuell påverkan En studie av förskolebarn med språkstörning Bakgrund Avhandlingen behandlar olika aspekter av språklig bearbetning hos barn med språkstörning. Barn med språkstörning har svårt att tillägna sig sitt modersmål trots att de växer upp i en enspråkig miljö. Dessa barn får problem i förskolan och ofta senare under skolåren efterLanguage Processing and Contextual Influence A Study of Swedish Preschool Children with Language Impairment The aim of the present work was to study different types of contextual influence on language performance in a variety of tasks: repetition of nonwords, narration, understanding of idioms and picture naming in a group of Swedish preschool children with language impairment (LI). The stress p

Methodologies and legislative frameworks regarding the archaeological excavation, retrieval, analysis, curation and potential reburial of human skeletal remains differ throughout the world. As work forces have become increasingly mobile and international research collaborations are steadily increasing, the need for a more comprehensive understanding of different national research traditions, metho

We derive a fundamental existence theorem for the equation u(t)'(x,t) - div(vertical bar del(x)u vertical bar(p-2)del(x)u) = 0 with continuous initial and boundary data in a space-tithe cylinder.

This article presents a study of how the use of around 40 different attenuation markers develops among five Swedish learners of Spanish during a four-month stay in Spain. The material was extracted from a corpus of semi-spontaneous discussions and simulated negotiations between native speakers of Spanish and Swedish learners. The results reveal a moderate increase of attenuation markers between th

Objectives:To compare the six-year outcome of a multidisciplinary rehabilitation program with continued care within primary care in terms of health-related quality of life and cost-effectiveness. Furthermore, predictors of total costs to society were examined. Methods:A prospective, matched, controlled, six-year follow-up was designed. The study included 236 patients (42 men, 194 women) nineteen

The European Spallation Source (ESS) is a neutron science facility funded by a collaboration of 17 European countries currently under design and construction in Lund, Sweden. The centerpiece of ESS is a 2.5 GeV proton linac utilizing superconducting RF cavities operating at 2 K. In addition to cooling the SRF cavities, cryogenics is also used at ESS in the liquid hydrogen moderators surrounding th

Underdrawings and pentimenti-typically revealed through x-ray imaging and infrared reflectography-comprise important evidence about the intermediate states of an artwork and thus the working methods of its creator.(1) To this end, Shahram, Stork and Donoho introduced the De-pict algorithm, which recovers layers of brush strokes in paintings with open brush work where several layers are partially v