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From the point of view of each individual’s sense-making, an organization is an emergent property of inter-individual sense-making processes and activities. The organization is a result of emergence from individual sense-making perspectives. A critically informed approach to research involves recognition / understanding of this emergence. Without the recognition of the uniqueness of each particula
In this study we have developed and validated a novel approach of transgene regulation in the brain. By using lentiviral vectors that incorporate promoters of genes that are up-regulated during different pathological states, we were able to regulate transgene expression in accordance with the disease process. When using a glial fibrillary acidic protein promoter, efficient disease regulation in gl
This study evaluates associations between objectively measured daily physical activity vs aerobic fitness and body fat in children aged 8-11 years. A cross-sectional study of 225 children aged 7.9-11.1 years was performed. Abdominal fat mass (AFM) and total body fat (TBF) were quantified by dual-energy x-ray absorptiometry. TBF was calculated as percentage of total body mass (BF%). Body fat distri
Ongoing inflammation including activation of the complement system is a hallmark of systemic lupus erythematosus (SLE). Antimicrobial neutrophil extracellular traps (NETs) are composed of secreted chromatin that may act as a source of autoantigens typical for SLE. In this study, we investigated how complement interacts with NETs and how NET degradation is affected by complement in SLE patients. We
Dopamine (DA) neurons derived from human embryonic stem cells (hESCs) are potentially valuable in drug screening and as a possible source of donor tissue for transplantation in Parkinson's disease. However, existing culture protocols that promote the differentiation of DA neurons from hESCs are complex, involving multiple steps and having unreliable results between cultures. Here we report a simpl
A Hidden Markov Model (HMM) is used to improve the robustness to noise when tracking the atrial fibrillation (AF) frequency in the ECG. Each frequency interval corresponds to a state in the HMM. Following QRST cancellation, a sequence of observed states is obtained from the residual ECG, using the short time Fourier transform. Based on the observed state sequence, the Viterbi algorithm, which uses
A novel immunoassay (PINC-ELISA) was designed using proteinase inhibitors of the cystatin superfamily (PINC) in the solid phase, to promote the selective capture of cysteine proteinases. The method was applied in the identification of papain-like antigens from parasitic protozoa. PINC of human origin, namely recombinant cystatin C (r-cystatin C) or low molecular weight kininogen were used in the a
The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection for benign hyperplasia or cancer of the prostate and compared with that of controls without antibiotic (Group III). Both regiments significantly reduced the frequency of postoperative bacteriuria (p less than 0.01) and of severe infectious com
The administration and management of organizations and companies is based upon the belief in the rationality of certain ideas Ð here referred to as management ideas Ð that is, the belief in these ideas1 ability to solve problems and provide opportunities for betterment. The talk of and writings on management ideas (lexis) constitute discursive formations that precede and shapes practices (praxis),
Popular Abstract in Swedish Varje år besöker ungefär 100 000 människor från hela världen klostret i den lilla franska byn Taizé. De flesta är ungdomar. Och 4000 av dem är svenskar. Här stannar de en vecka och deltar i brödernas intensiva andaktsliv tre gånger dagligen. Andakterna kännetecknas av meditativ tystnad och korta repetitiva mantra-lika sånger. Vad händer med en människas religiösa attityA considerably small amount of empirical research was found on the process of religious facilitation through liturgical participation and worship (cf., Heimbrock & Boudewijnse, 1990; Wikström, 1994a, 1994b). Using a quasi-experimental design, the present investigation therefore addressed this issue. The process of religious facilitation through intense liturgical participation was regarded as
Background and aims: Caregivers of Parkinson's disease patients are vulnerable to detrimental factors related to caregiving because of the progressive course of the disease. Studies of care-givers of these patients are scarce. The aim of this study was to examine the caregiver burden in Parkinson's disease by analyzing caregiver and patient-related factors. Methods: Every 3(rd) patient with Parkin
Popular Abstract in Swedish Denna doktorsavhandling i Rättssociologi handlar om barns rättigheter och barnarbete i Paraguay. Problematiken kring barnarbete i Paraguay är central för avhandlingen och författaren har undersökt samt beskrivit de rättsliga ideal som är tänkta att upprätthålla och stärka det rättsliga skyddet för barns rättigheter. De rättsliga idealen kontrasteras sedemera mot den norThe present study is composed of eight chapters relating to children's rights and child labor activity in the Republic of Paraguay. The problem of child labor in Paraguay is central for this study and the legal ideals that are intended to uphold and strengthen the rights of the child are described and contrasted with the present normative reality in which the children work and live. The discrepanc
Popular Abstract in Swedish På Internet initieras en mängd tjänster på många områden. Det är tjänster som på flera sätt ingår i vardagslivet. I avhandlingen undersöks en av dessa tjänster och sätthur den används. Avhandlingen är en studie av e-handel av livsmedel i Sverige i perioden 1998-2003. Det är en period då e-handel bedrivs av de flesta stora aktörer på den svenska livsmedelsmarknaden men äFrom a social constructivist point of view this thesis investigates how e-commerce of grocery develops in the period 1998-2003. The empirical research is done in Sweden. Most Swedish grocery concerns that have had e-commerce and have been forced to shut down as a result of lack of demand. The starting point for this thesis is that technological development is an ongoing process where different act
Objective To assess intraobserver and interobserver variability in ovarian volume and gray-scale and color flow index measurements using transvaginal, three-dimensional, power Doppler ultrasonography. Methods Eleven women (22 ovaries) were examined on day 8 of controlled ovarian hyperstimulation therapy, which was part of their in vitro fertilization treatment protocol. The patients were examined
Antigenic variation in microbial surface proteins represents an apparent paradox, because the variable region must retain an important function, while exhibiting extensive immunological variability. We studied this problem for a group of streptococcal M proteins in which the similar to 50-residue hypervariable regions (HVRs) show essentially no residue identity but nevertheless bind the same ligan
Popular Abstract in Swedish Denna rättssociologiska studie handlar om tvångsomhändertagna missbrukares rättssäkerhet under tiden i vård. Författaren undersöker begreppet rättssäkerhet i förhållande till tvångsvårdens verkställighet på så kallade LVM-hem i syfte att finna en begreppsdefinition som är operationaliserbar vid studier av rättssäkerhetens upprätthållande. Med utgångspunkt i resultaten Compulsory treatment and care is regulated by the Care of Alcoholics and Drug abusers Act (Lag (1988:870) om vård av missbrukare i vissa fall, LVM). The regulation's main purpose is to motivate persons with addictive problems to voluntarily participate in the treatment of their problems. The compulsory care shall continue for a maximum period of six months in special treatment centres (the so-call
In this study, two digital breast tomosynthesis (DBT) systems were evaluated: Siemens Mammomat Inspiration TOMO (Siemens Healthineers, Erlangen, Germany) and GE Senographe Pristina (GE, Buc, France). Along with differences such as angular range and detectors type, the systems use different reconstruction algorithms. One was available for the GE system, based on iterative reconstruction (IR). Two a
BACKGROUND: Problem behaviours are common among people with intellectual disabilities (ID), but psychometrically evaluated instruments for assessing such behaviours are scarce. The present study evaluated the psychometric properties of the Neuropsychiatric Inventory-Intellectual Disability (NPI-ID).METHOD: We assessed 108 residents with intellectual disabilities living in group-homes using the NPI
Purpose: This paper aims to unveil how sustainability is integrated into the courses/programmes of higher education institutions. The research question addressed is: how do academics representing different disciplines cooperate and engage in the work of integrating sustainability into their teaching programmes. Design/methodology/approach: This paper draws upon the notions of practise variation an
