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Aspects of infective endocarditis. Molecules, microbiology, management, and more.

AbstractEndocarditis, or heart valve infection, can be caused by a number of pathogens, many of which are Gram-positive bacteria. The diagnosis is based on imaging techniques such as echocardiography and on blood culture. The implementation of fast and accurate species identification methods, such as the matrix-assisted laser desorption/ionisation-time of flight mass spectrometry (MALDI-TOF MS) in

High-Sensitivity Assessment of Phagocytosis by Persistent Association-Based Normalization

Phagocytosis is measured as a functional outcome in many research fields, but accurate quantification can be challenging, with no robust method available for cross-laboratory reproducibility. In this study, we identified a simple, measurable parameter, persistent prey-phagocyte association, to use for normalization and dose-response analysis. We apply this in a straightforward analytical method, p

Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development.

Although bone marrow (BM) represents the main site for postnatal NK cell development, recently a distinct thymic-dependent NK cell pathway was identified. These studies were designed to investigate the role of cytokines in regulation of thymic NK cells and to compare with established regulatory pathways of BM-dependent NK cell compartment. The common cytokine receptor gamma-chain (Il2rg) essential

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.

Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into this question, a panel of mouse monoclonal antibodies was generated against a major triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines modified by cit

Colorectal cancer-infiltrating T lymphocytes display a distinct chemokine receptor expression profile

Background: T lymphocytes exert important homeostatic functions in the healthy intestinal mucosa, whereas in case of colorectal cancer (CRC), infiltration of T lymphocytes into the tumor is crucial for an effective anti-tumor immune response. In both situations, the recruitment mechanisms of T lymphocytes into the tissues are essential for the immunological functions deciding the outcome. The recr

Tillage practices and their impact on soil organic carbon and the microbial community

ATT PLÖJA MYCKET, LITE ELLER INGET ALLS Vi blir fler och fler människor på vår planet, och år 2050 beräknas vi vara så många som 10 miljarder. Det innebär att vi måste kunna producera mer mat på en lika stor eller till och med mindre yta jämfört med idag. En stor del av den mat vi konsumerar produceras antingen direkt eller indirekt på åkrar runt om i världen. För lantbrukare som är inriktade på vSoil microorganisms are important for climate regulation as well as for plant nutrition. In agricultural soils the microorganisms are affected by management choices, like which type of tillage that is used. Moldboard plowing, the most common tillage practice, increases mineralization which leads to soil organic carbon (SOC) loss, and may thus reduce soil quality. Conservation tillage practices inf

Network of positive affect and depression in older adults : Twin study

Objectives: Higher levels of positive affect (PA) are consistently associated with lower depressive symptoms in older adults; however, the relative importance of specific PA components remain unclear. This study examined which discrete PA facets show the strongest associations with depressive symptoms and whether these associations reflect genetic or environmental influences using twin methodology

Arteriovenous fistula stenosis detection using wavelets and support vector machines

The objective of this exploratory study was to develop signal processing methods for assisting in the diagnosis of arteriovenous fistula stenosis on patients suffering from end-stage renal disease and undergoing haemodialysis treatments. The proposed method is based on the classification of vessels sounds utilizing parameter extraction from wavelets transform coefficients. The coefficients energy

Acute pancreatitis - costs for healthcare and loss of production.

Abstract Objective. Severity of acute pancreatitis (AP) can vary from a mild to a fulminant disease with high morbidity and mortality. Cost analysis has, however, hitherto been sparse. The aim of this study was to calculate the cost of acute pancreatitis, both including hospital costs and costs due to loss of production. Material and methods. All adult patients treated at Skane University Hospital

Gr alla kursplaner

Microsoft Word - Alla kursplaner GR i word.docx   Musiklärarutbildningen  Ämneslärare  7-­‐9         Ämneslärarutbildning i Musik 7-9   Ämneslärarutbildningen  i  musik  syftar  till  att  utbilda  lärare  med  mycket  goda  lärar-­‐ kunskaper  parat  med  en  gedigen  musikalisk  grund.  Utbildningen  startar  med  första   ämnet   (musik)   från   termin   ett   varvat  med   kurser   i   UVK  

https://www.mhm.lu.se/sites/mhm.lu.se/files/gr_alla_kursplaner.pdf - 2026-06-01

Governance arrangements for the implementation of transformative innovation policy : insights from a comparative case study

There has been great interest in the rationales for transformative innovation policies (TIP), including those following a mission-oriented logic. However, few studies have investigated how public administration can effectively implement TIP. To study this, we first identify from existing literature four TIP governance tasks (creating legitimacy and leadership, coordination across levels/instrument

Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination

The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of pathogen contact is essential for preventing viral spread. Influenza A virus (IAV) in humans preferentially replicates in the upper respiratory tract (URT) but mouse models of infection result in lower respiratory tract infection. Here, we optimize IAV inoc

Internet of Things (IoT) enabled Blockchain for traceability in fresh produce supply chain

With global food supply chains becoming more complex, the credibility of the food sector is under threat due to the loss of public trust with rising food fraud cases such as the horsemeat scandal, Chinese milk scandal, etc. Therefore, it has become essential to promote transparency and real-time visibility of the food supply chain from farm to fork to address the demand of all the stakeholders inv

Distinct immune microenvironments in ovarian cancer subtypes indicate potential for immunotherapies

BackgroundTo enable immunotherapy for ovarian cancers, precision targets for immune priming as well as patient stratification approaches are required. The tumor microenvironment in particularly the rare subtypes of low-grade serous, mucinous, clear cell and endometrioid ovarian cancer, remains poorly characterized, and these tumors have been largely ignored in the immuno-oncology setting.MethodsWe