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The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced througho

This work has been made as a thesis for a BSc degree in Fire Protection Engineering at Lund University. The work has been supported and funded by ESS AB, European Spallation Source, in Lund. ESS AB is a publicly held company, owned by Sweden and Denmark as host countries. These host countries, together with at least 17 other European countries, will build and establish a multidisciplinary research

Objective - To examine select adipokines, including fatty acid-binding protein 4, retinol-binding protein 4, and high-molecular-weight (HMW) adiponectin in relation to cardiovascular disease (CVD) mortality among patients with type 2 diabetes mellitus. Approach and Results - Plasma levels of fatty acid-binding protein 4, retinol-binding protein 4, and HMW adiponectin were measured in 950 men with

AIMS/HYPOTHESIS: Salt-inducible kinases (SIKs) are related to the metabolic regulator AMP-activated protein kinase (AMPK). SIK2 is abundant in adipose tissue. The aims of this study were to investigate the expression of SIKs in relation to human obesity and insulin resistance, and to evaluate whether changes in the expression of SIKs might play a causal role in the development of disturbed glucose

Randomized controlled trials (RCT) are often underpowered for validating gene-treatment interactions. Using published data from the Diabetes Prevention Program (DPP), we examined power in conventional and genotype-based recall (GBR) trials. We calculated sample size and statistical power for gene-metformin interactions (vs. placebo) using incidence rates, gene-drug interaction effect estimates and

The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic mechanisms in disease development. Here we present an epigenome-wide association study across 406,365 CpGs in 52 monozygotic twin pairs discordant for T1D in three immune effector cell types. We observe a substantial enrichment of differentially vari

Glycogen metabolism in β-cells may affect downstream metabolic pathways controlling insulin release. We examined glycogen metabolism in human islets and in the rodent-derived INS-1 832/13 β-cells and found them to express the same isoforms of key enzymes required for glycogen metabolism. Our findings indicate that glycogenesis is insulin-independent but influenced by extracellular glucose concentr

Circulating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain. We previously identified novel metabolites correlated with insulin sensitivity measured by the hyperinsulinemic-euglycemic clamp. The top-ranking metabolites were in the glutathione and glycine biosynthesis pathways. We aimed to ide

Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and beta-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interact

Signalling through gap junctions contributes to control insulin secretion and, thus, blood glucose levels. Gap junctions of the insulin-producing β-cells are made of connexin 36 (Cx36), which is encoded by the GJD2 gene. Cx36-null mice feature alterations mimicking those observed in type 2 diabetes (T2D). GJD2 is also expressed in neurons, which share a number of common features with pancreatic β-

This dissertation is a study of metaphors of emotion in rebétiko song texts. Rebétiko is a major popular-music style of modern Greece, consisting mostly of melancholic songs full of sorrow, disappointment, and misfortune, as well as passion and romance, but also of cheerful songs of revelry and a carefree attitude to life. Rebétiko as a music style developed in the Greek-speaking world and its dia

In a recent genome-wide association study, WD-repeat domain 12 (WDR12) was associated with early-onset myocardial infarction (MI). However, the function of WDR12 in the heart is unknown.

Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF=1.4%) with lower FG (β=-0.09±0.01

OBJECTIVE-A genome-wide association study (GWAS) in Pima Indians (n = 413) identified variation in the ataxin-2 binding protein 1 gene (A2BP1) that was associated with percent body fat. On the basis of this association and the obese phenotype of ataxin-2 knockout mice, A2BP1 was genetically and functionally analyzed to assess its potential role in human obesity. RESEARCH DESIGN AND METHODS-Variant

Context Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI), but large-scale multicenter studies have not been conducted. Objective To determine the diagnostic accuracy of CSF beta-amyloid(1-42) (A beta 42), total tau protein (T-tau), and tau phosphorylated at po

Context: Whether a healthy lifestyle may be associated with longer telomere length is largely unknown. Objectives: To examine healthy lifestyle practices, which are primary prevention measures against major age-related chronic diseases, in relation to leukocyte telomere length. Design and Setting: Cross-sectional analysis in the Nurses' Health Study (NHS). Participants: The population consisted of

The purpose of this study was to describe nurses' experiences of interactions with family members in intensive care units. Ten experienced Registered Nurses were interviewed, and the interview text was qualitatively analysed by its content. Nursing of families was experienced as an essential, necessary and demanding task, and no systematic assessment and intervention with families were talked abou

Bemanningsbranschen har under de senaste årtiondena vuxit kraftigt i Sverige och är idag en etablerad del av arbetsmarknaden. Behovet av att reglera bemanningsbranschen rättsligt insåg EU redan tidigt och efter många turer och skilda åsikter i frågan så kunde EU 2008 beslutaom bemanningsdirektivet. Direktivet skulle vara genomfört i Sverige senast 2011 men blev klart först i januari 2013 då uthyrnThe temporary agency work business has grown considerably over the last decades in Sweden. The need to regulate the business by law was recognized early on by the EU. After a long process and many divergent opinions, the Temporary Agency Work directive was finally agreed upon in 2008. The directive should have been implemented in Sweden in 2011 but the law enforcing it, uthyrningslagen, was not fi

I samband med kommersiella avtalsförhandlingar upprättas många olika förhandlingsdokument. Parterna kan skriva sekretessavtal, letters of intent, aktieägaravtal, anställningsavtal och överlåtelseavtal – för att nämna några. Under förhandlingarnas gång skickas många förhandlingsbud och åtskilliga avtalsförslag, avseende det slutliga överlåtelseavtalet, mellan parterna. Ett letter of intent bringaIn a contract negotiation a variety of negotiation documents are created. The parties may sign confidentiality agreements, letters of intent, shareholder agreements, employment agreements and transfer agreements – to name a few. During negotiations, many offers and proposals regarding the final transfer agreement are exchanged between the parties. A letter of intent brings order and clarity in a

Veikimoräner är cirkulära moräner med ryggar längs kanterna som kan hittas i norra Sverige. Majoriteten är belägna längs en N-S gående kuperat landskap. Moränerna tros ha bildats under tidig-mellan Weichsel och har överlagrats av glaciärer från efterföljande glaciationer. Tack vare att Veikimoränerna har bevaratas i så gott skick kan dessa moräner ge värdefull information om glaciationer och dåvarVeiki moraine is a landform area consisting of rim-ridged subcircular hummocks and plateaus with depressions in between, mostly located within a N-S extending zone of a hummocky landscape. It is believed to have formed during the pre-late Weichselian and survived overriding by ice during the subsequent glaciations. Due to their good preservation, the Veiki moraine provides valuable information on