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Ovarian cancer is usually found at a late stage when the prognosis is often bad. Relative survival rates decrease with tumor stage or grade, and the 5-year survival rate for women with carcinoma is only 38%. Thus, there is a great need to find biomarkers that can be used to carry out routine screening, especially in high-risk patient groups. Here, we present a large-scale study of 64 tissue sample
A prevalence of hepatitis C virus (HCV) antibodies of 12% was found in 276 patients from 11 dialysis units. Between zero and 22% of the patients in the different units were anti-HCV positive. The epidemiology of HCV was studied in two units during a 2 year period by antibody assays and the polymerase chain reaction and correlated with clinical manifestations. Two types of epidemiologic patterns we
In type-1 diabetes mellitus (T1DM) with diabetic nephropathy (DN), accumulation of abnormal proteins in the kidney and other tissues may derive from constitutive alterations of intracellular protein recognition, assembly, and turnover. We characterized the proteins involved in these functions in cultured skin fibroblasts from long-term T1DM patients with [DN+] or without [DN-] nephropathy but simi
Recurrent circuitry components are distributed widely within the brain, including both excitatory and inhibitory synaptic connections. Recurrent neuronal networks have potential stability problems, perhaps a predisposition to epilepsy. More generally, instability risks making internal representations of information unreliable. To assess the inherent stability properties of such recurrent networks,
Popular Abstract in Swedish Inledningen till avhandlingens första kapitel tar avstamp i en diskussion om normativa (hur man bör göra) och deskriptiva (hur man faktiskt går tillväga) förhandlingsteorier. Normativa teorier bygger på antaganden om att människor kan och vet i stort sett allting och de ger råd om hur man bör göra. De deskriptiva förhandlingsteorierna försöker förklara hur människor fakScholars within the Process school assume that cognitive and motivational aspects within the decision and integration processes may systematically effect the outcome of mergers and acquisitions. More specifically, it has been suggested that decision makers use heuristics for simplifying information processing which may introduce bias. The main aim of the present thesis is to add to the understandi
Background & objectives: We have earlier proposed that group A streptococcal (GAS) immunoglobulin binding surface proteins (IgGBPs) might trigger anti-IgG production and immune complex formation leading to glomerulonephritis. In the present study, cardiac tissue material from rabbits injected with heat-killed GAS was investigated. Methods: Rabbits were injected intravenously with 10(9) colony
Two assertions made by the Eastern meditation traditions were investigated: (a) breath regulation is a prerequisite for attaining altered states of consciousness, (b) meditation leads to changes in cognitive processes and in personality. A deconditioning process was conceptualized involving the temporal lobes and the amygdala. Analyses of (a) the effects of carbon dioxide (CO2) inhalation and (b)
Introduction: There is a shortage of tools designed for use by occupational therapy practice in Arabic-speaking countries. The purpose of this study was to translate and cross-culturally adapt the original Satisfaction with Daily Occupations tool to Arabic and assess the psychometric properties of the adapted tool. Method: A cross-cultural adaptation process was performed. Face, content, and crite
OBJECTIVE: The purpose of the study was to determine the prevalence and factors associated with injury in professional ballet and modern dancers, and assess if dancers are reporting their injuries and explore reasons for not reporting injuries. DESIGN: Cross-sectional study. SETTING: Participants were recruited from nine professional ballet and modern dance companies in Canada, Denmark, Israel,
This thesis has contributed to the methodological development in the field of assistive technology and has generated new knowledge about the effectiveness and the service delivery process when powered mobility devices are provided to adult first time users in a Nordic context. Some of the results have been used to investigate the relationship between the three key elements of Donabedian’s conceptu
Popular Abstract in Swedish Något tillspetsat förefaller varje kommun driva utvecklingsarbete inriktat på verksamhetsmått. Är så inte fallet är ansvariga snabba att betona att verksamhetsmått är viktigt och att de precis har beslutat om ett större måttprojekt. Denna bok ger en bild av i vilken omfattning fyra gatukontor utformar och använder verksamhetsmått. Boken innehåller också beskrivningar ocThe purpose of this study is to develop a frame of reference within which formal control system performance measures can be described and their design and use can be analyzed for control systems in municipalities. From a cybernetic control approach measures are used as instruments to plan and gain feedback from employee actions, and adjust them to the internal and external environment of which the
Cholera toxin (CT) binds to GM1-ganglioside receptors present on all nucleated cells. Despite this, it is a very potent mucosal adjuvant that has a dramatic impact on immune cells, as well as nerve and epithelial cells, causing diarrhea. This fact has hampered our understanding of whether the adjuvanticity of CT is direct or indirect, as cells that bind CT may or may not be involved in its adjuvan
The low specificity of screening ELISAs for antibodies to hepatitis C virus in blood donors has called for confirmatory tests. Two types of supplementary antibody assays are available, recombinant immunoblot assays (RIBA-1 and RIBA-2) and an antibody consumption test referred to as a neutralization assay. Amplification of viral nucleic acid by the polymerase chain reaction (PCR) provides an antibo
Chemical management services (CMS) is an application of the Product Service System in the chemical sector. It is a new business model based on a long term relation between customers and service suppliers, who both have the same goal of reducing the costs and volume of chemicals used in the customer's processes. CMS started in the early 1980's in the US and transferred to Europe later. CMS
This work discusses a policy maker-student relation taking into account educational standards, asymmetric information and incentives for students to study well. The problems discussed are the characteristics of developing countries. To define educational standards is not enough for an efficient educational system. Supervision is desired to minimize moral hazard and not to loose the best students.
This dissertation offers a unique examination of Muslim masculinities and marginalized sexualities in Lebanon, and is a contribution to the growing body of gay and lesbian studies with a focus on Muslims living in The Middle East. It contributes to the theoretical and methodological development of Islamic studies by introducing and using a queer approach to study marginalized sexualities in relati
Popular Abstract in Swedish Huvud- hals cancer Studier kring betydelsen av kärltäthet, svar på strålbehandling och tumörmetabolism, undersökt med positron emissions tomografi ( PET) Bakgrund Cancer i huvud-hals området är ovanligt i Sverige och utgör c:a 2,5% av alla nya cancerfall (40 000) per år. Beteckningen är ett samlingsnamn för tumörer med sinsemellan skilda egenskaper, uppkomna från i förTreatment options of head and neck squamous cell carcinoma (HNSCC) usually include combinations of radiotherapy and surgery, and in some cases addition of chemotherapy. In locally advanced cases cure rates are low. Current prognostic factors cannot foresee the outcome for the individual patient. There is consequently a need for reliable prognostic and predictive factors. Through identification of
OBJECTIVE: The overall objective was to unfold the phenomenon of interrater agreement: to identify potential sources of variation in agreement data and to explore how they can be statistically accounted for. The ultimate aim was to propose recommendations for in-depth examination of agreement to improve the reliability of assessment instruments. STUDY DESIGN AND SETTING: Using a sample where 1
