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Effect of exogenous glutamate and N-Methyl-D-aspartic acid on spontaneous activity of isolated human ureter

OBJECTIVES: While the neurotransmitter role of glutamate in the gastrointestinal tract has been shown, its effects on smooth muscle of the human ureter have not previously been investigated. In our study we have investigated the effects of exogenous glutamate on the spontaneous activity of isolated human ureter, taken from 14 adult patients after nephrectomy.METHODS: The segment of ureter, excised

Patient-reported outcome measures for hip-related pain : A review of the available evidence and a consensus statement from the International Hip-related Pain Research Network, Zurich 2018

Hip-related pain is a well-recognised complaint among active young and middle-aged active adults. People experiencing hip-related disorders commonly report pain and reduced functional capacity, including difficulties in executing activities of daily living. Patient-reported outcome measures (PROMs) are essential to accurately examine and compare the effects of different treatments on disability in

Effect of intensive training on lower leg structural strength: an in vivo study in ovariectomized rats

The aim of this study was to investigate the effect of training on the in vivo tibial structural strength during the development of post-ovariectomy osteoporosis. Seventeen mature Wistar rats (215 g) were ovariectomized and randomized into two groups. The sedentary control group was kept cage confined, while 3 days postoperatively the trained group started treadmill running with high intensity for

Angular dispersion and temporal change of femtosecond pulses from misaligned pulse compressors

A misaligned stretcher or compressor in a chirped pulse amplification laser introduces residual angular dispersion into the beam, resulting in temporal distortion of the pulse. We demonstrate that an imaging spectrograph is capable for Measuring the angular dispersion of a laser beam by an accuracy of 0.2 murad/min. Using this technique, the analytical expressions of residual angular dispersion of

CD44/CD70 blockade and anti-CD154/LFA-1 treatment synergistically suppress accelerated rejection and prolong cardiac allograft survival in mice.

Current treatments that are efficient in controlling effector T cells responses to allografts have limited efficacy on the accelerated rejection mediated by memory T cells. Effective targeting of alloreactive memory T cells may therefore be explored to improve therapeutic approaches towards solving this problem. In this study, we investigated the synergistic effect of CD44/CD70 blockade and anti-C

From (p)ppGpp to (pp)pGpp : Characterization of regulatory effects of pGpp synthesized by the small alarmone synthetase of Enterococcus faecalis

The bacterial stringent response (SR) is a conserved stress tolerance mechanism that orchestrates physiological alterations to enhance cell survival. This response is mediated by the intracellular accumulation of the alarmones pppGpp and ppGpp, collectively called (p)ppGpp. In Enterococcus faecalis, (p)ppGpp metabolism is carried out by the bifunctional synthetase/hydrolase E. faecalis Rel (RelEf)

Occupational Injuries to Senior Farmers in Sweden

The prevailing demographic change in the western world means that theworkforce is becoming older. Farmers in particular often work beyond the normalretirement age, in a challenging physical environment. For example, the agriculturalsector has the most hazardous work environment in Sweden. Therefore, it is interestingto examine the following questions: Are senior farmers more frequently involvedin

Fia attent (Watch out!): Surveillance and Intimacy in Ethnographic Research

Several articles in the Recalling Fieldwork collection discuss the role of state surveillance and how it affected our ethnographic fieldwork. This was certainly the case in my own research in Romania in the decade from 1974-1985, where my secret police (Securitate) file ended up being over 600 pages long, and where I was blacklisted in 1985 due to hostile activities. Other ethnographers had simila

Sublingual misoprostol vs. oral misoprostol solution for induction of labor : A retrospective study

Introduction: Induction of labor (IOL) is one of the most common obstetrical procedures, with an increasing rate. The prostaglandin E1 analogue misoprostol is frequently used as a primary method of labor induction. The optimal dose and route of administration is yet to be ascertained. Aim: To compare efficiacy and safety between a regimen of sublingually administered misoprostol and a regimen of o

Ruins of Resilience : Imaginaries and Materiality Imagineered and Embedded in Civil Defence Architecture

This chapter examines ruin towns: civil defence training grounds that replicated urban war zones. The ruins provided a stage for enacting nuclear war, where the merely imagined was given a tangible expression. The chapter sketches the transnational extension-by-invitation of a British model of ruins to Denmark, and through architectural and historical analysis, it asks how it was re-embedded into

Business Rules Friendly or not so Business Rules Friendly Business Concepts Modelling - Early Experiences from a Business Rules Project on a Digital Vaccination Recommendation Service

WHO estimated in 2002 that 1.4 million children in the world would die from preventable diseases (World Health Organization, 2010). Each child is, or should be, immunized according to their national immunization schedule, which regulates i.e. vaccines and doses. Problems emerge when immigrant children should be transferred from one national vaccination schedule into another. This problem is quite

How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?

Abstract: Animal models of Parkinson's disease (PD) are important for understanding the mechanisms of the disease and can contribute to developing and validating novel therapeutics. Ideally, these models should replicate the cardinal features of PD, such as progressive neurodegeneration of catecholaminergic neurons and motor defects. Many current PD models emphasize pathological forms of α-synucle

Real life testing of a hybrid PEM fuel cell bus

Fuel cells produce low quantities of local emissions, if any, and are therefore one of the most promising alternatives to internal combustion engines as the main power source in future vehicles. It is likely that urban buses will be among the first commercial applications for fuel cells in vehicles. This is due to the fact that urban buses are highly visible for the public, they contribute signifi

Home and health among different sub-groups of the ageing population : A comparison of two cohorts living in ordinary housing in Sweden

Background: At present a majority of older people remain in their ordinary homes. Research has generated knowledge about home and health dynamics and increased the awareness of the complexity of housing as related to ageing. As this knowledge is based mainly on research on very old, single-living people in ordinary housing there is a need to study other sub-groups of the ageing population. Thus, t

Knee injury and Osteoarthritis Outcome Score (KOOS) - Validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The

Human eeg responses to exact and statistical fractal patterns.

Attention Restoration Theory point to nature as a particularly good candidate for restoring the ability to focus and inhibit distractions. However, little effort has been directed to elaborating on what makes nature's visual pattern unique for restoration purposes. One suggested explanation is the fractal properties of natural patterns (Hagerhall, 2005). Both perception studies (Hagerhall et al.,

The role of cellular RNA processing functions in Human papillomavirus type 16 gene regulation

Infections with Human papillomavirus type 16 (HPV16) is the most the most common, sexually transferred and is responsible for genital warts, cervical cancers and a growing number of head and neck cancers. Knowledge about how HPV16 interacts with the infected cell to regulate its gene expression is essential for therapeutic development. Here, we show that the viral E5 protein which may contribute t

The Offender, the crime and the victim

In addition to Malmö having the most reported crimes in relation to its population, it is also one of the cities in the country with the highest percentage of gun-related violence. Our earlier studies show that people who commit serious crimes such as homicide or attempted homicide in Malmö are primarily single, have no psychiatric diagnosis and mainly use knives or other sharp weapons to commit t