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BACKGROUND: The impact of the environmentally sustainable EAT-Lancet diet on dementia risk remains poorly understood. The aim was to investigate associations between the EAT-Lancet diet and incident dementia.METHODS: Associations of the EAT-Lancet diet with all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were investigated among 25,898 participants from the Malmö Diet and
Determining the land cover (LC) data requirements used as input to noise simulations is essential for planning sustainable urban densifications. This study examines how different LC datasets influence simulated environmental noise levels of road traffic using Nord2000 in an urban area of 1 km2 in southern Sweden. Four LC datasets were used. The first dataset was based on satellite data (spatial re
Purpose: The purpose of this case-control study was to investigate the associations between maternal serum concentrations of vitamin D early in pregnancy and the occurrence of preterm birth. Methods: The study included 269 women (cases) whose children were born preterm (< 37 gestational weeks [gw]) and 332 women (controls) whose children were born term (≥ 37 gw). Among the cases, 59 were extreme p
Background: In Sweden, dental care for children and adolescents, including specialist orthodontic treatment, is publicly funded. This study aims to analyze the impact of sociodemographic factors on the distribution of publicly funded specialist orthodontic treatment in a mid-sized Swedish region. Methods: A registry-based cohort study was conducted in Region Östergötland, including individuals bor
BACKGROUND: Atrial fibrillation (AF) is suggested to be associated with venous thromboembolism (VTE) and might thereby play a role in the development of chronic thromboembolic pulmonary hypertension (PH). By elevating left-sided filling pressure and promoting atrial myopathy, AF may also play a role in the development of postcapillary PH. We aimed to investigate the association between AF, with or
Imaging-defined atherosclerosis represents an intermediate phenotype of atherosclerotic cardiovascular disease (ASCVD). Genome-wide association studies (GWAS) on directly measured coronary plaques using coronary computed tomography angiography (CCTA) are scarce. In the so far largest population-based cohort with CCTA data, we performed a GWAS on coronary plaque burden as determined by the segment
Prediction of incident macrovascular events (iMEs) in individuals with type 2 diabetes (T2D) remains suboptimal. We aim to discover blood-based epigenetic biomarkers predicting iMEs in 752 newly diagnosed individuals with T2D, among whom 102 developed iMEs during follow-up. 461 DNA methylation sites, e.g., near ARID3A, GATA5, HDAC4, IRS2, and TMEM51, associate with iMEs. Using cross-validation, a
Several lines of evidence suggest that a calcitonin-gene related peptide (CGRP) receptor antagonist may serve as a novel abortive migraine treatment. Here we present data on a human cell line and isolated human vessels for such an antagonist, BIBN4096BS. On SK-N-MC membranes, radiolabelled CGRP was displaced by both CGRP-(8-37) and BIBN4096BS, yielding pK(i) values of 8.5 and 11.4, respectively. F
Abstract in Undetermined Background: Measured or modeled levels of outdoor air pollution are being used as proxies for individual exposure in a growing number of epidemiological studies. We studied the accuracy of such approaches, in comparison with measured individual levels, and also combined modeled levels for each subject's workplace with the levels at their residence to investigate the influe
The request for alternatives to dairy products have increased for some years now. This has led to an increase of different kinds of vegetable milks and yoghurts on the market. Quinoa is a herb from South America and due to the versatility of this herb and its exceptional nutritional value it is an excellent example on functional food with health effects that is induced from all the active compound
Background: Change is something all organizations experience, and in the fast-paced business-world that is today, the ability to change needs to be higher than ever. The problem is, individuals hate change, it is in our genes to resist it, which complicates how organizations can navigate the change-landscape. To solve this, new ways to work with change arise every day and the latest trend: change
In medieval Scandinavia, parchment was a crucial writing material for everything from property deeds and judicial matters to religious works and account keeping. As society became more and more invested in literacy, the demand for parchment grew. However, the supply of animals for parchment could not increase to the same extent without great changes in animal husbandry. This thesis explores how me
Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supe
Under 1700- och 1800-talet var judars rättigheter i Sverige starkt begrän-sade. Genom 1782 års judereglemente tilläts judar bosätta sig i Sverige under särskilda villkor samtidigt som de var föremål för omfattande re-striktioner. Under 1800-talet blev frågan om judars rättigheter och den ju-diska emancipationen ett omdebatterat ämne i Sveriges riksdag. År 1838 fick judar utökade rättigheter genom During the 18th and 19th centuries, the rights of Jews in Sweden were seve-rely restricted. Under the Jew Statute of 1782, Jews were permitted to settle in Sweden under certain conditions, while at the same time being subject to extensive restrictions. During the 19th century, the question of Jewish rights and Jewish emancipation was a heavily debated topic in the Swedish parliament. In 1838, Jews
Accurately predicting terrestrial ecosystem responses to climate change over long-timescales is crucial for addressing global challenges. This relies on mechanistic modeling of ecosystem processes through land surface models (LSMs). Despite their importance, LSMs face significant uncertainties due to poorly constrained parameters, especially in carbon cycle predictions. This paper reviews the prog
Forests play a crucial role in Europe’s strategy for achieving carbon neutrality. Carbon turnover time - the time that carbon spends in the ecosystem - is a fundamental component in determining forest potential to mitigate climate change. However, there is a significant knowledge gap regarding how current and future forest management practices will affect carbon turnover time. This study aims to c
Pediatric cancers exhibit complex evolutionary dynamics driven by genetic instability, clonal selection, epigenetic reprogramming, and microenvironmental interactions. Tumor evolution is typically characterized by branching phylogenies, where subclones with unique genetic profiles emerge at different locations and time points. Partly as a result of this diversity, advanced cancers often develop re
