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We used site-directed mutagenesis to alter the specificity of human cystatin C, an inhibitor with a broad reactivity against cysteine proteinases. Nine cystatin C variants containing amino acid substitutions in the N-terminal (L9W, V10W, V10F and V10R) and/or the C-terminal (W106G) enzyme-binding regions were designed and produced in Escherichia coli. It was discovered that the inhibition profile

Aims: A study was undertaken to assess the impact of social participation, trust and the miniaturization of community, i.e. high social participation/low trust, on two measures of patient dissatisfaction in primary healthcare. Methods: The Scania 2000 public-health survey is a cross-sectional, postal questionnaire study. A total of 3,456 persons aged 18-80 years who had a regular doctor within the

The angular pattern of scattered X-ray radiation (1.2-2.5 Angstrom) from flames has been measured and analyzed. The results are compared with calculations on different molecules, such as polyaromatic hydrocarbons, fullerenes and other spherical structures. Measurements have also been performed on soot condensed on a cooling plate inserted inside a flame. Size- and shape-dependent structures are ob

We report on experimental absolute oscillator strengths for 18 UV lines of Ru II, obtained by combining laser-induced fluorescence measurements of radiative lifetimes and branching fractions from line intensities in a calibrated Fourier-transform spectrum. HST/GHRS observations of the spectrum of the sharp-lined B star chi Lupi contain six of these lines, for which ''astrophysical'' relative f-val

Fluence-response relationships for the enhancement of ultraweak luminescence by UV radiation were determined in leaves of Brassica napus L. (cv. Ceres) when either the adaxial or abaxial leaf surface was exposed to monochromatic radiation (270–340 nm). Action spectra for both leaf surfaces were constructed from the fluence-response curves at the fluence required to obtain a doubling of the ultrawe

Aims: A study was undertaken to investigate the relationship between country of birth, time in Sweden, and overweight and obesity. Methods: Approximately 4,000 people aged 20-80 participated in a cross-sectional survey in 1994. The ethnic differences in overweight and obesity were analysed in a multivariate logistic regression analysis adjusting for age and education. The effect of number of years

To study how quickly cervical proprioceptive information induced muscular responses in the lower leg to control posture in the standing human we investigated lower leg muscle electromyography and force-plate data from 10 healthy normal subjects, when perturbed by posterior neck muscle vibration. At the onset of vibration the tibialis anterior muscle was activated at latencies of 70-100 ms whilst t

PURPOSE: To determine the relevance of dilatations of the common femoral artery (CFA), knowledge of the normal CFA diameter is essential. The diameter of the CFA in healthy male and female subjects of different ages was investigated. METHODS: The diameter of the CFA was measured in 122 healthy volunteers (59 male, 63 female; 8 to 81 years of age) with echo-tracking B-mode ultrasound scan. The infl

A piece of a human thoracic duct removed at operation was investigated in organ baths. The duct was cut in 8 ring segments each about 1mm long and isometric tension recorded. The segments were exposed to a potassium rich (124mM) Krebs buffer solution. In only two of the segments were contractions induced (7.2 and 1.0mN, respectively). Noradrenaline and the thromboxane mimetic U-46619 induced tonic

Objectives: The aim of the present study was to analyze the effect of an enhanced systematic dose of nicotine on osseointegration of titanium implants. Material and methods: Sixteen female rabbits received either nicotine ( n = 8) or saline ( n 8) administered subcutaneously via mini-osmotic pumps for 2 months. The pump delivered 6 mg/kg/min of nicotine for the animals in the test group. Blood was

PURPOSE: To characterize the clinical phenotype, with emphasis on electrophysiology, of members of a Swedish family with autosomal dominant retinitis pigmentosa due to a novel mutation, F211L, in the peripherin/RDS gene. METHODS: Nine patients with autosomal dominant retinitis pigmentosa and two healthy family members underwent a full clinical evaluation including kinetic visual field testing, mea

This study describes the removal of polycyclic aromatic hydrocarbons (PAHs) from creosote oil contaminated soil by modified Fenton's reaction in laboratory-scale column experiments and subsequent aerobic biodegradation of PAHs by indigenous bacteria during incubation of the soil. The effect of hydrogen peroxide addition for 4 and 10 days and saturation of soil with H2O2 on was studied. In both exp

Inclusive production of D* mesons in deep-inelastic ep scattering at HERA is studied in the range 5 < Q(2) < 100 GeV2 of the photon virtuality and 0.02 < y < 0.7 of the inelasticity of the scattering process. The observed phase space for the D* meson is (pT) (D*) > 1.25 GeV and |eta( D*)| < 1.8. The data sample corresponds to an integrated luminosity of 348 pb(-1) collected with the H1 detector. S

This Letter presents measurements of correlated production of nearby jets in Pb+Pb collisions at root s(NN) = 2.76 TeV using the ATLAS detector at the Large Hadron Collider. The measurement was performed using 0.14 nb(-1)of data recorded in 2011. The production of correlated jet pairs was quantified using the rate, R-Delta R, of "neighbouring" jets that accompany "test" jets within a given range o

Enticing economic benefits for host nations and the notion of large areas of land considered available are often put forward as the main reasons for large-scale land acquisition in many areas of sub-Saharan Africa. However, country-level datasets of land acquisitions seem to indicate a clear divide between a majority of countries engaged in land acquisitions as investors and those involved as targ

In the caddisfly Molanna angustata, females produce a sex pheromone in glands with openings on the fifth sternite. Gas chromatographic analyses of pheromone gland extracts with electroantennographic detection revealed four major compounds that stimulated male antennae. These compounds were identified by means of gas chromatography-mass spectrometry and enantioselective gas chromatography as heptan