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Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer.

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Female sex workers (FSWs) are the second most affected population by HIV in Iran. However, their HIV testing practices are poorly understood. The aim of this study was to investigate testing and its associated factors among HIV negative FSWs.

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Aims Orthostatic hypotension (OH) has been linked to increased mortality and incidence of cardiovascular disease in various risk groups, but determinants and consequences of OH in the general population are poorly studied. Methods and results Prospective data of the Swedish 'Malmö Preventive Project' (n = 33 346, 67.3% men, mean age 45.7 +/- 7.4 years, mean follow-up 22.7 +/- 6.0 years) were analy

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To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal muscle from individuals with (FH(+)) or without (FH(-)) an FH of T2D. We found differential DNA methylation of genes in biological pathways including mitogen-activated protein kinase (MAPK), insulin, and calcium signaling (P

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The paper presents an experimental study on heat transfer coefficients in a straight rectangular channel containing continuous transverse ribs. The ribs were located on one side of the channel which is heated with a uniform heat flux. Three values of the rib pitch-to-height ratio (10, 20 and 30) were considered, with the Reynolds number, based on the channel hydraulic diameter, ranging from 57,000

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Abstract This paper aims to gain a better understanding of the impact different micro-geometries has on stress distribution in cutting tools. Both principal and effective stress distribution are studied since these quantities have a major impact on the occurrence of damages in the cutting tool such as crack formation, flaking, chipping, breakage and plastic deformation. The development of a stagna

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The overall aim of the chapter is to reflect a classroom project on creative learning processes by four “dialogues” between researcher and teacher perspectives on a sequence of themes that lead up to the morale of the tale; Computers and learning, Creativity and education, Creative teaching and Creative learning.

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This thesis concerns the analysis of anthropogenic substances of the compound class known as persistent organic pollutants (POPs). Sample preparation perspectives for the analysis of POPs in the environmental matrices water, soils and sediments are presented. This thesis features reasonably cheap and uncomplicated methodology capable of fast screening of POPs. It displays how quantitative extract

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The complex interplay by tunneling and scattering in quantum cascade lasers is analyzed with nonequilibrium Green's functions. Data for a recently proposed simple structure based on only two wells per period is presented. This simple structure allows to visualize the relevance of the tunneling resonance very clearly. It is argued that a QCL design needs at least three levels per period, thus furth

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A fast 2D motion estimator has been developed and evaluated. The method does not utilize block-matching or iterative solutions and is thus more computationally efficient and suitable for real-time motion estimation over the entire image. The method has been evaluated on 1) phantom measurements and 2) in vivo on the carotid artery wall of 17 subjects, where measurements of the longitudinal displace

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Summary. We assessed the reliability and construct validity of the Compatible MRI scale for evaluation of elbows, and compared the diagnostic performance of MRI and radiographs for assessment of these joints. Twenty-nine MR examinations of elbows from 27 boys with haemophilia A and B [age range, 5–17 years (mean, 11.5)] were independently read by four blinded radiologists on two occasions. Three c

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Increased tourist activity and recreational use of wilderness and other protected areas has endangered zones of high environmental value. The aim of this work was to evaluate the effects of trampling intensity (low, high use trails and untrampled trails) and distance from the trails (on the trails, at 10 and 20m from the trails) on the vegetation, chemical, physical and microbiological properties

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An 11-year-old boy with mental retardation, malformations, and the mosaic karyotype 47,XY,+i(8p)/46,XY presented with fever, headache and petechiae. Peripheral blood WBC was 190 x 10(9)/l; and contained > 90% mature eosinophils. Cytogenetic analysis of the eosinophils revealed no aberrations except the constitutional karyotype. The patient was diagnosed as having a hypereosinophilic syndrome. Shor

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In this seminar paper, I attempt an in-depth analysis of a collection of articles published in historical periodicals in Finland 1990-2000. My main interest concerns how the writers – mainly professional historians, representatives of scientific ideals of their age – discussed the idea of the Finnish nation during this decade, and how these discussions reflect a certain understanding of the work o

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The scientific knowledge of climate change processes and their worrying future implications for human societies and natural systems has developed considerably during the last decade, but necessary adaptive actions by decision makers have so far been rather limited. There are several causes to this, such as a discrepancy related to the communication between climate scientists and end-users, and the

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The popular uprisings that swept many countries in the Middle East during the last three years have been subject to much academic analysis that attempted to interpret the events and their significance for future political developments in the region. Discursive tropes such as revolution, counter-revolution, sectarian strife, and terrorism have been used in such analyses as they have been utilized b