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Although the nuclear era and the Cold War superpower competition have long since passed, governments are still investing in Big Science, although these large facilities are nowadays mostly geared towards areas of use closer to utility. Investments in Big Science are also motivated not only by promises of scientific breakthroughs but also by expectations (and demands) of measurable impact, and with
Theoretical predictions show that depending on the populations of the Fe 3d(xy), 3d(xz), and 3d(yz) orbitals two possible quintet states can exist for the high-spin state of the photoswitchable model system [Fe(terpy)(2)](2+). The differences in the structure and molecular properties of these B-5(2) and E-5 quintets are very small and pose a substantial challenge for experiments to resolve them. Y
Amyloid-beta (A beta) pathology is a major component in the mechanisms behind Alzheimer's disease (AD). Measurement of A beta(42) in cerebrospinal fluid predicts cognitive decline in patients with mild cognitive impairment and identifies AD in patients with dementia. However, studies on A beta in plasma are contradictory. In this prospective population-based study, plasma A beta(42) and A beta(40)
Introduction: Our objective was to study mandibular widening in untreated subjects with hemifacial microsomia. Methods: From the 3-dimensional files at the Department of Plastic and Reconstructive Surgery, Skane University Hospital in Malmo, Sweden, data of 11 subjects (3 girls, 8 boys) with hemifacial microsomia were retrieved. Their age range was 9 years 2 months to 13 years 2 months at the firs
A novel linear parameterization for the variable flip angle method for longitudinal relaxation time T1 quantification from spoiled steady state MRI is derived from the half angle tangent transform, t, of the flip angle. Plotting the signal S at coordinates x=St and y=S/t, respectively, establishes a line that renders signal amplitude and relaxation term separately as y-intercept and slope. This re
La chimie des otolithes de poissons sert a associer les poissons a des environnements specifiques. La chimie des otolithes peut aussi potentiellement servir d'outil dans la recherche phylogenetique, comme nous le demontrons ici chez les poissons salmonides et les taxons apparentes. Des cartes bidimensionnelles de la chimie de Zn:Ca dans les otolithes montrent des oscillations annuelles d'amplitude
Knowledge of the processes favouring the establishment of exotic parasites is poor. Herein, we test the characteristics of successful exotic parasites that have co-established in the remote island archipelago of New Zealand, due to the introduction of numerous avian host species. Our results show that avian malaria parasites (AM; parasites of the genus Plasmodium) that successfully invaded are mor
Scanning tunneling microscopy (STM), X-ray photoelectron spectroscopy (XPS), and first principles theoretical calculations have been used to gain insight into the fundamental processes involved in the adsorption and self-assembly of oxalic acid on Cu(111). The experimental data demonstrate that several reaction pathways are involved in the chemisorption of oxalic acid on Cu(111), one of which lead
An increased understanding of cellular uptake mechanisms of macromolecules remains an important challenge in cell biology with implications for viral infection and macromolecular drug delivery. Here, we report a strategy based on antibody-conjugated magnetic nanoparticles for the isolation of endocytic vesicles induced by heparan sulfate proteoglycans (HSPGs), key cell-surface receptors of macromo
Urban planning regulations influence not only the urban form; they also have a great impact on the microclimate in urban areas. This paper deals with the relationship between the urban planning regulations and microclimate in the hot dry city of Damascus. The main purpose is to highlight the shortcomings of the existing urban planning regulations. The microclimatic parameters necessary for the the
We investigated the distribution, storage and landscape partitioning of soil amorphous silica (ASi) in a central Canadian region dominated by tundra and peatlands to provide a first estimate of the amount of ASi stored in Arctic permafrost ecosystems. We hypothesize that, similar to soil organic matter, Arctic soils store large amounts of ASi which may be affected by projected climate changes and
Helianthemum nummularium is a morphologically variable species that has been subdivided into several subspecies based on indumentum characters. We investigated four of these subspecies for variation in plastid DNA and leaf and petal shape in Europe. Three size-variable mononucleotide repeat regions were amplified by means of species-specific primers and 18 combined haplotypes were identified. The
Relative efficacy and toxicity of cyclophosphamide compared with ifosfamide are debatable. The Euro-EWING99-R1 trial asked whether cyclophosphamide may replace ifosfamide in combination with vincristine and dactinomycin (vincristine, dactinomycin, and cyclophosphamide [VAC] v vincristine, dactinomycin, and ifosfamide [VAI]) after an intensive induction chemotherapy containing vincristine, ifosfami
The European Union (EU) military Operation Headquarters (OHQ) construct has been described as a slow starter due to familiarization issues and an arena for parallel chains of command. Similarly, a recent study of a live OHQ showed national perspectives to be common, particularly with staff members from nations prominent in the operation. However, the nature of these flaws remains unclear while sch
Introduction. Berries contain high amounts of dietary fibre and flavonoids and have been associated with improved metabolic health. The mechanisms are not clear but the formation of SCFAs, especially propionic and butyric acids, could be important. The potent antioxidant and antimicrobial properties of flavonoids could also be a factor, but little is known about their fate in the gastrointestinal
Objective: In this study the activation of HMGA2 and overexpression by FGF1-driven stimulation of adipose tissue derived stem cells (ADSCs) in adipose tissue tumors were analyzed. In addition, the expression of HMGA2 and PPAR-gamma mRNA were quantified in canine subcutaneous abdominal adipose tissue from normal and overweight purebred dogs. Design and Methods: ADSCs and adipose tissue explants sti
BACKGROUND: Rye and wheat bran were treated with several xylanases and endoglucanases, and the effects on physicochemical properties such as solubility, viscosity, water-holding capacity and particle size as well as the chemical composition of the soluble and insoluble fractions of the bran were studied. A large number of enzymes with well-defined activities were used. This enabled a comparison be
The most frequently used animal models for Parkinson's disease (PD) utilize unilateral injection of 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle (MFB), which results in total denervation of the dopaminergic nigrostriatal pathway. However, neuroprotective interventions in PD require models resembling earlier stages of PD, where some dopaminergic cells and fibres remain. The aim of the
