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Background: Activating KRAS mutations are common in ovarian carcinomas of low histological grade, less advanced clinical stage and mucinous histological subtype, and form part of the distinct molecular alterations associated with type I tumors in the dualistic model of ovarian carcinogenesis. Here, we investigated the occurrence, clinicopathological correlates and prognostic significance of specif
Samples of compositionally (highly) asymmetric diblock copolymers and, also, mixtures of diblock and triblock copolymers (the latter obtained as end-coupling products of two diblock molecules of the mixture), composed of (a) monodisperse majority block(s) of poly(styrene) (PS) and a polydisperse minority block of poly(methacrylic acid) (PMAA), microphase separate into spherical PMAA microdomains,
The authors address the dichotomy around 'proximate' and 'distant' learning processes by looking specifically at the characteristics of the knowledge-creation process. By way of suggesting an alternative conceptualization to the well-known tacit-codified knowledge dichotomy, they propose a distinction between 'analytical' and 'synthetic' modes of knowledge creation. Analytical knowledge creation r
Background: Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives: To determine respiratory tract deposition o
Fire accidents in underground transportation systems, e.g., tunnels and underground stations, can cause many fatalities. It is therefore important in fire safety design to give adequate consideration to all aspects related to evacuation. The paper provides a review of two previously reported fire accidents based on a theoretical framework, namely four accepted human behaviour theories. These theor
We present the formulation of a scattering matrix method for the study of light-scattering properties of metal films. The method is employed for the study of the optical excitation of surface plasmons in a gold film of 15-230 nm thickness, patterned periodically with subwavelength nanoholes. The gold film is placed on a thick SiO2 wafer, and the nanoholes as well as the top side of the gold film a
A numerical model was developed of beach morphological evolution in the vicinity of coastal structures. The model includes five sub-models for random wave transformation, surface roller development, nearshore wave-induced currents, sediment transport, and morphological evolution. The model was validated using high-quality data sets obtained during experiments with a T-head groin and a detached bre
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that, if not treated, will progress into blast crisis (BC) of either myeloid or B lymphoid phenotype. The BCR-ABL1 fusion gene, encoding a constitutively active tyrosine kinase, is thought to be sufficient to cause chronic phase (CP) CML, whereas additional genetic lesions are needed for progression into CML BC. To generate a humanize
Background: Chlamydia trachomatis is the most common cause of sexually transmitted infections globally and the leading cause of preventable blindness in the developing world. There are two biovariants of C trachomatis: 'trachoma', causing ocular and genital tract infections, and the invasive 'lymphogranuloma venereum' strains. Recently, a new variant of the genital tract C trachomatis emerged in S
The overall aim of thesis was to explore frail older people’s experiences of receiving healthcare and/or social services and to investigate healthcare consumption and costs in both men and women and in different age groups in the two years prior to the introduction of long-term municipal care. A second aim was to explore a preventive intervention in a pilot study using case managers to older peopl
A measurement of the W boson mass and width has been performed by the DELPHI collaboration using the data collected during the full LEP2 programme (1996-2000). The data sample has an integrated luminosity of 660 pb(-1) and was collected over a range of centre-of-mass energies from 161 to 209 GeV. Results are obtained by applying the method of direct reconstruction of the mass of the W from its dec
New tools and forms of cooperation at the landscape level are needed in order for forestry and environmental conservation to co-exist in areas with many land owners. Awareness has existed for several years in Sweden that cooperation at the landscape level is essential for protecting areas of high environmental value. This awareness has come to expression in several projects and initiatives. One of
BACKGROUND: Arsenic (As) causes oxidative stress through generation of reactive oxygen species. 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a sensitive marker of oxidative DNA damage, has been associated with As exposure in some studies, but not in others, possibly due to population-specific genetic factors. OBJECTIVES: To evaluate the association between As and 8-oxodG in urine in a population
This study investigates several commercial selective catalytic reduction (SCR) catalysts (A–E) for application in a high-temperature (approximately 525 °C) and high-concentration (5000 ppm NO) system in combination with CO2 capture. The suggested process for removing high concentrations of NOx seems plausible and autothermal operation is possible for very high NO concentrations. A key property of
Objectives To determine the accuracy of established ultrasound dating formulae when used at 12-14 weeks of gestation. Methods One-hundred and sixty-seven singleton pregnancies conceived after in-vitro fertilization (IVF) underwent a dating scan at 12-14 weeks of gestation. Gestational age at the dating scan was calculated by adding 14 days to the number of days between the date of oocyte retrieva
Extracorporeal immunoadsorption (ECIA) is a new method for the selective removal of circulating radiolabeled monoclonal antibodies (MAb) from plasma to increase the uptake in tumor versus normal tissues (T/N-ratio). To ascertain whether the amount of MAb affects T/N ratios immediately and 24 h after ECIA, we used a rat model with two tumor sites--one intramuscular (im) and one below the subrenal c
Two methylcelluloses (MC) were investigated by partial hydrolysis followed by direct infusion electrospray ionisation mass spectrometry (ESI-MS). Partial hydrolysis was achieved either enzymatically or by acid hydrolysis. Enzyme hydrolysis was performed using the endoglucanase Bacillus agaradhaerens Cel 5a. Three different hydrolysis buffer solutions were investigated in order to deter-mine which
Empowerment has become a widespread concept in various social policy contexts referring to different marginalized groups. Empowerment has also been focused within the mental health field although little empirical research exists. The aim of the present study was to investigate internal consistency and construct validity of the Swedish version of an empowerment scale developed for people with a men
Chitosan was chosen as a natural polymer for dispersion of single walled carbon nanotubes (SWNT) based on its ability to efficiently solubilize SWNTs to form a stable dispersion. Moreover, chitosan films deposited on a surface of a glassy carbon (GC) electrode are mechanically stable. Further stabilisation of the chitosan film containing SWNT (CHIT-SWNT) was done by chemical crosslinking with glut
