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A maximum likelihood methodology for a general class of models is presented, using an approximate Bayesian computation (ABC) approach. The typical target of ABC methods are models with intractable likelihoods, and we combine an ABC-MCMC sampler with so-called "data cloning" for maximum likelihood estimation. Accuracy of ABC methods relies on the use of a small threshold value for comparing simulat
Background A crucial issue for the sustainability of societies is how to maintain health and functioning in older people. With increasing age, losses in vision, hearing, balance, mobility and cognitive capacity render older people particularly exposed to environmental barriers. A central building block of human functioning is walking. Walking ifficulties may start to develop in midlife and become
Lytic polysaccharide monooxygenases (LPMOs) are copper metalloenzymes that can enhance polysaccharide depolymerization through an oxidative mechanism, making them interesting for the production of biofuel from cellulose. However, the details of this activation are unknown; in particular, the nature of the intermediate that attacks the glycoside C–H bond in the polysaccharide is not known, and a nu
A way to reduce net CO2 emission and circumvent the high particle emissions from compression ignition (CI) engines, while retaining high efficiency, is by utilizing lighter alcohols in the partially premixed combustion (PPC) process. Methanol and ethanol have a very short carbon chain, and form less soot/particulate matter (PM) during combustion compared to diesel fuel. This study analyzes and com
Given that Alcohol Use Disorder (AUD) is clinically heterogeneous, can we, in a large epidemiological sample using public registries, identify clinical features of AUD cases in biological and step-fathers that index, respectively, genetic and familial-environmental risk for AUD in their offspring? From all father-offspring pairs where the father had AUD and the offspring was born 1960–1990, we ide
The chapter will give an overview of the history and actual status of three pertinent aspects of mental illness stigma: public stigma, discrimination and self-stigma, and the evidence for interventions to diminish stigma and discrimination. Stigma and discrimination are still important aspects of the lives of people with mental illness with negative consequences in a number of life domains. The st
We present a real-time study of protein crystallization of bovine-lactoglobulin in the presence of CdCl2 using small-angle X-ray scattering and optical microscopy. From observing the crystallization kinetics, we propose the following multistep crystallization mechanism that is consistent with our data. In the first step, an intermediate phase is formed, followed by the nucleation of crystals withi
Background: Anti-citrullinated protein antibodies (ACPA) have been suggested to have a potential role in both bone loss and pain in rheumatoid arthritis (RA), based on studies in vitro and in animal models. Here we addressed if anti-cyclic citrullinated (anti-CCP) antibodies were associated with osteopenia or pain in patients with RA, at the time for diagnosis. Methods: Baseline data from the BARF
The aim was to evaluate conceptual scoring of lexical organization in bilingual children with language impairment (BLI) and to compare BLI performance with monolingual children with language impairment (MLI). Word associations were assessed in 15 BLI and 9 MLI children. BLI were assessed in Arabic and Swedish, MLI in Swedish only. A number of syntagmatic (semantic link, different word class) and p
Abstract Regnell, Astrid: Att se stjärnor på ljusa dagen. Förvandling och försoning i August Strindbergs En blå bok. Seeing stars in broad daylight. Transformation and Reconciliation in August Strindberg’s Zones of the Spirit. In this thesis a pattern of coherence is explored in August Strindberg’s Zones of the Spirit (En blå bok) – a literary work consisting of a collection of short and quite div
The particle number size distribution is an important parameter to characterize the atmospheric aerosol and its influence on the Earth's climate. Here we describe a new optical particle size spectrometer (OPSS) for measurements of the accumulation mode particle number size distribution in the tropopause region on board a passenger aircraft (IAGOS-CARIBIC observatory: In-service Aircraft for a Glob
We present a rigorous phase noise analysis of a generic harmonic oscillator where the active core can be modeled as a transconductor. Phase noise equations are derived without any specific assumption on the nature of the resonator in the oscillator; furthermore, we provide closed-form 1/f2 phase noise equations when the resonator consists of an arbitrary number of cascaded LC tanks, each tuned at
Deception research has neglected the fact that legal-workers often have to try to detect deceit on the basis of statements derived from pairs of suspects, each having been interrogated repeatedly. To remedy this shortcoming we conducted a study where each member of 10 truth-telling pairs and 10 lying pairs was interrogated twice about an alibi. One hundred and twenty undergraduate students were en
Anomaly detection is becoming a powerful and necessary component as wireless networks gain popularity. In this paper, we evaluate the efficacy of PCA based anomaly detection for wireless mesh networks (WMN). PCA based method [1] was originally developed for wired networks. Our experiments show that it is possible to detect different types of anomalies, such as Denial-of-service (DoS) attack, port
The focus of this paper is to derive the symbol error probability (SEP) of a Rake receiver with a limited number of fingers that track the strongest multipath components in a frequency-selective Rayleigh fading channel. We develop an analytical framework that allows the computation of the SEP for nonuniform power dispersion profiles (PDPs) and spreading bandwidth. By transforming the physical Rake
