Filtyp
Genetic changes underlie tumor progression and may lead to cancer-specific expression of critical genes. Over 1100 publications have described the use of comparative genomic hybridization (CGH) to analyze the pattern of copy number alterations in cancer, but very few of the genes affected are known. Here, we performed high-resolution CGH analysis on cDNA microarrays in breast cancer and directly c
The association of seropositivity to human papillomavirus (HPV) capsids of types 11, 16, 18, or 33 with sexual behavior was investigated. Among 1002 women visiting family planning or youth clinics in Sweden, an age-matched subsample of 274 women stratified according to lifetime number of sex partners was analyzed. The proportion of HPV-16-seropositive subjects increased linearly at approximately 4
Popular Abstract in Swedish Denna avhandling beskriver hur fluorescens kan användas inom biomedicinområdet. Fluorescens är ett fenomen, som uppstår när molekyler absorberar inkommande ljus och sedan återutsänder ljus som har längre våglängd än det inkommande ljuset, och därför lägre energi, då en del av det absorberade ljuset omvandlats till värme i det omkringliggande mediet. I mänsklig vävnad fi
This paper presents an analysis of the impact of childbearing history on later-life mortality for ever-married men and women using historical micro-level data of high quality for southern Sweden. The analysis uses a Cox proportional hazards model, estimating the effects on old-age mortality of number of births and timing of first and last births. By studying the effects of previous childbearing on
Objective: To estimate the occurrence of hand eczema in hairdressers in Sweden. Methods: The occurrence of hand eczema was estimated in a Swedish longitudinal retrospective cohort study including all female graduates from vocational schools for hairdressers from 1970 to 1995. A stratified sample from the general population acted as controls. A self-administered questionnaire including questions on
The presence of rings and gaps in protoplanetary disks are often ascribed to planet-disk interactions, where dust and pebbles are trapped at the edges of planetary-induced gas gaps. Recent works have shown that these are likely sites for planetesimal formation via the streaming instability. Given the large amount of planetesimals that potentially form at gap edges, we address the question of their
A method was developed for the simultaneous demonstration of two specific cellular constituents. Cryostat sections of formaldehyde fixed tissue from retinae treated with ((3)H)-5-hydroxytryptamine were subjected to immunohistochemistry and subsequent autoradiography. The method takes advantage of the very efficient and specific uptake mechanism that many types of neurons possess which makes it pos
Introduction: Treatment options for peritoneal metastases (PM) from colorectal cancer (CRC) have increased, their efficiency should be monitored. For this purpose, register-based data on PM can be used, if valid. Purpose: We aimed to evaluate the completeness and positive predictive value (PPV) of synchronous peritoneal metastases (S-PM) registered among CRC patients in the Danish National Patient
A large number of experiments have found a moderate degree of dependence between subsequent tests of recognition and cued recall as described by the TW-function. This paper investigates the dependence in word pair recognition. Tests of word pair recognition are conducted with the subsequent test being free recall, cued recall, recognition, and cued recognition. The dependence is compared to subseq
The environment in which biology exists has dramatically changed during the last decades. Life was formed during billions of years, exposed to, and shaped by the original physical forces such as gravitation, cosmic irradiation and the terrestrial magnetism. The existing organisms are created to function in harmony with these forces. However, in the late 19th century mankind introduced the use of e
Infectious diseases that can be transmitted via air often spread rapidly, sometimes causing large epidemic and pandemic outbreaks. As an increasing number of people live in crowded urban environments, and with frequent and long-distance traveling across the world, infectious diseases can spread even faster. Yet, our knowledge of how much airborne transmission (here defined as aerosol particles <10
Library assessment and external intelligence is important for tracking and improving library activities. Quality assurance and strategic planning are intricate parts in sustainably developing better and more effective services. Gothenburg University Library has implemented a process with the goal to join these activities. The process has both bottom-up and top-down features designed to generate st
Abstract--- This paper follows directly from our forthcoming paper in International Journal of Machine Consciousness, where we discuss the requirements for an artefact to be a moral agent and conclude that the artefactual question is ultimately a red herring. As we did in the earlier paper, we take moral agency to be that condition in which an agent can, appropriately, be held responsible for her
Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen i världen bland kvinnor och bara i Sverige insjuknar varje år runt 7000 personer. Vi vet att omkring 10-15% av fallen troligen beror på ärftliga faktorer och det har under senare tid gjorts stora insatser för att klargöra exakt vilka arvsanlag som har betydelse för utveckling av sjukdomen. Under början av 90-talet identifieradeHereditary breast cancer constitutes a considerable fraction of the total number of breast cancer cases occurring each year. Up until recently very few breast cancer predisposing genes were known, but many new common polymorphisms contributing to increased cancer susceptibility are continuously being identified. This thesis has focused on familial breast cancer and identifying as well as investi
