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The number of electrically driven loads in a modern vehicle is constantly increasing. Many loads that former were mechanically driven will in the future be driven by electricity. This implies that a number of electronic systems have to be packed together in the limited space in a vehicle. When different electronic systems are placed close to each other, there is always a risk for electromagnetic i
Background: Reported improvements in outcome in stroke patients treated in hospital are often attributed to advances in stroke care. However, secular trends in patient characteristics that are present already on admission to hospital may also contribute to improved outcome. Methods: Time trends for baseline data (289,854 stroke admittances) in Riks-Stroke, the Swedish national quality register for
Whey protein adsorption on stainless steel surfaces was investigated by in situ ellipsometry under well-defined flow conditions and protein solution residence times. The size distribution in solution of the protein aggregates formed under the same conditions was determined by dynamic light scattering. The adsorption was performed at 72 degrees C and 85 degrees C which is below and above the unfold
Resistance to the HER-2 targeting drug trastuzumab can be observed clinically, but the lack of suitable experimental models hampers studies of resistance mechanisms. We characterized a HER-2–positive carcinoma cell line (JIMT-1) derived from a 62-year-old breast cancer patient which was clinically resistant to trastuzumab. Multicolor fluorescence in situ hybridization revealed a complex hyperdiplo
Popular Abstract in Swedish Allt eftersom fler och fler organismers totala uppsättning gener, genomet, sekvenseras ökar fokus på att kartlägga de genprodukter, proteiner, som uttrycks. Att kunna studera de proteiner som uttrycks mer eller mindre vid olika tidpunkter eller cellulära tillstånd utgör en viktig del i sökandet efter kunskap om biologiska och medicinska processer. Studier av den totala The study of the protein complement of a genome is called proteomics. Proteomics can be defined as identification, quantification and characterization of a total set of proteins expressed at different time-points or under different cellular states to provide global information about biological processes. The study of membrane proteins is a challenging area in the development of proteomic research.
Whilst Building Information Modelling (BIM) promises significant improvements in construction quality and efficiency, current contractual models do not encourage its use; indeed actively inhibit the collaboration at its core. To help bring BIM into the mainstream, it is claimed we need to re-craft existing contractual relationships to facilitate collaborative decision making and to equitably alloc
Popular Abstract in Swedish C-Med 100, en naturmedicin med immunomodulerande egenskaper Vårt immunsystem skyddar oss mot infektioner från bakterier, virus och parasiter. För att detta ska fungera behövs många olika egenskaper och idag delas immunsystemet in i två delar, en ospecifik och en specifik. Den ospecifika delen består av hud, slemhinnor, magsyra och olika celler som snabbt tar sig till etExtracts from the bark of the vine Uncaria tomentosa have anti-inflammatory, antiviral, antimutagenic and antioxidant effects. In this study, we evaluate the effects of an Uncaria tomentosa extract, denoted C-Med 100, on the cellular level of the immune system both in vivo and in vitro. Our results indicated that lymphocytes had significantly prolonged half life after in vivo supplementation with
Background: The relationship between plasma markers of inflammation and the incidence of chronic obstructive pulmonary disease (COPD) is still unclear. This population-based study explored whether raised levels of five inflammation-sensitive plasma proteins (ISPs) predicted hospital admissions for COPD during 25 years of follow-up. Methods: Spirometric tests and measurements of five ISPs (fibrinog
The cloud-nucleating properties of the atmospheric aerosol were studied in an area under strong influence of vegetation burning. The measurements were part of Large-Scale Biosphere Atmosphere Experiment in Amazonia-Smoke Aerosols, Clouds, Rainfall and Climate (LBA-SMOCC) and were carried out at a ground site located in the state of Rondonia in southwestern Amazonia, Brazil, September to November 2
We examined the effects of the immunophilin ligands and calcineurin inhibitors FK506 and cyclosporin A on the survival of rat embryonic dopamine (tyrosine hydroxylase (TH)-immunoreactive) neurons. The protective effects of FK506 and cyclosporin A were first studied in dissociated mesencephalic cell cultures subjected to serum deprivation. Significant increases in both the total number of surviving
Huntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant HD gene mediates a slowly progressing striatal neurotoxicity is unknown. Glutamate receptor-mediated excitotoxicity has been hypothesized to contribute to the pathogenesis of HD. Here we show that trans
Recent Hubble Space Telescope observations of a large sample of globular clusters reveal that every cluster contains between 40 and 400 blue stragglers.The population does not correlate with either stellar collision rate (as would be expected if all blue stragglers were formed via collisions) or total mass (as would be expected if all blue stragglers were formed via the unhindered evolution of a s
Breast cancer susceptibility genes BRCA1 and BRCA2 are tumour suppressor genes the alleles of which have to be inactivated before tumour development occurs. Hereditary breast cancers linked to germ-line mutations of BRCA1 and BRCA2 genes almost invariably show allelic imbalance (Al) at the respective loci. BRCA1 and BRCA2 are believed to take part in a common pathway in maintenance of genomic inte
Background. To further improve the outcome of clinical islet transplantation analysis of the impact of donor- and process-related factors could be of great importance. Materials and Methods. Thirty-eight consecutive clinical islet transplantations were performed with consecutive islet isolations. Univariate analysis for donor- and isolation-related variables were correlated with recipient C-peptid
Microalbuminuria is an early sign of diabetic nephropathy. The aim of the present study was to investigate whether the changes of the glomerular filtration barrier in early experimental diabetes are due to size- or charge-selective alterations. Wistar rats, made diabetic by streptozotocin (STZ) and having their blood glucose maintained at similar to 20 mM for 3 or 9 wk, were compared with age-matc
Popular Abstract in Swedish Olika rapporter har fastslagit att de traditionella svenska folkrörelserna (såsom arbetarrörelsen och frikyrkorörelsen) tappar medlemmar. Istället för att ansluta sig till ett politiskt parti eller en kyrka söker sig politiskt eller religiöst intresserade individer till nya, individualiserade, former av engagemang. Denna avhandling studerar en grupp män och kvinnor somVarious reports have stated that the traditional Swedish popular movements (e.g. the Workers movement and the Free church movement) are loosing ground. Instead of joining a political party or a church, politically or religiously active individuals are said to seek out new and individualized ways of being involved. This thesis studies a number of men and women that persist in being communally invo
A number of policy instruments are used in order to provide consumers healthy products produced in a proper way as regards environmental impacts. The policy instruments are mainly directed to enterprises and companies producing products. Such actors are often addressed in terms of laws or regulations and represent different actors in a production chain. Policy instruments and the way they are used
