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Philadelphia (Ph) chromosome-positive leukemia is characterized by the BCR/ABL1 fusion protein that affects a wide range of signal transduction pathways. The knowledge about its downstream target genes is, however, still quite limited. To identify novel BCR/ABL1-regulated genes we used global gene expression profiling of several Ph-positive and Ph-negative cell lines treated with imatinib. Followi
Objectives: Genome-wide association studies have revealed over 200 genetic susceptibility loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be generated to predict risk of PCa. We summarize the published evidence and conduct meta-analyses of PRS as a predictor of PCa risk in Caucasian men. Patients and methods: Data were extracted from 59 studies, with 16 studies i
The production of the W± bosons measured in p–Pb collisions at a centre-of-mass energy per nucleon–nucleon collision sNN = 8.16 TeV and Pb–Pb collisions at sNN = 5.02 TeV with ALICE at the LHC is presented. The W± bosons are measured via their muonic decay channel, with the muon reconstructed in the pseudorapidity region −4 < ηlabμ < −2.5 with transverse momentum pTμ > 10 GeV/c. While in Pb–Pb col
Exposure to excessive indoor radon causes around 500 lung cancer deaths in Sweden annually. However, until 2020, indoor radon measurements were only conducted in around 16% of Swedish single-family houses and 17% of multifamily houses. It is estimated that approximately 16% of single-family houses exceed the indoor radon reference level of 200 Bq/m3, and the corresponding situation in multifamily
The measurement of the transport of scalar quantities within flows is oftentimes laborious, difficult or even unfeasible. On the other hand, velocity measurement techniques are very advanced and give high-resolution, high-fidelity experimental data. Hence, we explore the capabilities of a deep learning model to predict the scalar quantity, in our case temperature, from measured velocity data. Our
Introduction Individual cognitive behavioural therapy (CBT) with exposure and response prevention is an effective treatment for obsessive-compulsive disorder (OCD). However, individual CBT is costly and time-consuming, requiring weekly therapy sessions for 3-4 months. A 4-day intensive version of CBT for OCD delivered in group format has been recently developed in Norway (Bergen 4-day treatment, B
Cows produce saliva in very large quantities to lubricate and facilitate food processing. Estimates indicate an amount of 50–150 L per day. Human saliva has previously been found to contain numerous antibacterial components, such as lysozyme, histatins, members of the S-100 family and lactoferrin, to limit pathogen colonization. Cows depend on a complex microbial community in their digestive syste
Sweden’s rapid economic growth after World War II meant that the native labour supply was incapable of meeting the high demand, especially for industrial labourers. Three agreements on organised collective transfers were signed, but a large majority of the labour migrants came on their own initiative. Not all applicants were equally welcomed. In this article, logistic regressions are used to inves
Our aim was to identify the best diagnostic test sequence for predicting Alzheimer's disease (AD)-type dementia in subjects with mild cognitive impairment (MCI) using cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) biomarkers. We selected 153 subjects with mild cognitive impairment from a multicenter memory clinic-based cohort. We tested the CSF beta amyloid (A beta)1-42/tau ratio u
Background: The development of factor (F) VIII neutralizing alloantibodies (inhibitors) is a major complication of treatment with FVIII concentrates in hemophilia A and the etiology is still poorly understood. The low-affinity Fc gamma receptors (Fc gamma R), which are expressed on immune cells, provide an important link between cellular and humoral immunity by interacting with IgG subtypes. Genet
Introduction: Gas6, the protein product of the growth arrest specific gene 6, is present in human circulation at subnanomolar concentrations. It is secreted by endothelial cells and is important for the activation of endothelium during inflammation. Axl, the tyrosine kinase receptor for Gas6, is also present in endothelium and can be cleaved and released into the circulation. The soluble of form A
Background. Cardiovascular (CVD) risk factors have been shown to cluster in some children. This has been shown in children from the age of nine years, but recently we found no clustering in six-year old children. It is uncertain when clustering develops and which parameters are related to the development of clustered CVD risk. Methods. A longitudinal study including 484 children aged six years. Th
Smoking is an established risk factor for pancreatic cancer, previously investigated by the means of questionnaires. Using cotinine as a biomarker for tobacco exposure allows more accurate quantitative analyses to be performed. This study on pancreatic cancer, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC cohort), included 146 cases and 146 matched controls.
Study Design. A multicenter, randomized, controlled, cost-effectiveness analysis. Objective. To assess the cost-effectiveness of balloon kyphoplasty (BKP) compared with standard medical treatment (control) in patients with acute/subacute (<3 months) vertebral compression fracture (VCF) due to osteoporosis. Summary of Background Data. Patients with a VCF due to osteoporosis are common and will incr
The presence of a criminal underworld is one of the characteristics of a metropolis. A city unplagued by an underworld, without its share of confidence tricksters and swindlers, burglars and pick-pockets, gambling dens and houses of ill-repute, would probably not be generally counted as a great city. This is certainly true today, and it was also true four hundred years ago, and even earlier. Peki
On the decision of the Swedish government, the Swedish National Road Administration (SNRA) has started a large-scale trial with Intelligent Speed Adaptation (ISA) in urban areas. One of the four test sites is the city of Lund. At the Department of Technology and Society, Lund University, research about ISA has been carried out since 1986 and the first field study was carried out in 1993. The ongoi
Popular Abstract in Swedish Fosterövervakning under förlossningen är standard inom förlossningsvården. Målet är att identifiera avvikande händelser och då speciellt syrebrist hos fostret. Sedan början på sjuttiotalet har vågformsanalys av foster EKG studerats ur fysiologisk, klinisk och signal synpunkt. Vågformen hos ett EKG innehåller mer information än bara R-R intervallet i ett EKG dvs konventiWaveform analysis of the fetal electrocardiogram has been studied since the early seventies from both physiological, signal processing and clinical aspects. It has been found to contain more useful information than the mere detection of RR-intervals (fetal heart rate), e.g., the ST-segment giving evidence of the ability of fetal myocardium to respond to the stress of labor. In the Swedish RCT, STA
Most types of materials and components use heating during the manufacturing process, with a large potential for cost and energy savings. Induction heating is the most energy efficient industrial heating technology for many applications, but so far technical limitations has delayed large scale introduction. The difficulties relate to heating of large flat and curved surfaces, and, perhaps most impo
In this work, we introduce novel techniques for adapting the SCA-LDPC framework to conduct efficient plaintext-checking (PC) oracle-based side-channel attacks on NTRU-style Key Encapsulation Mechanisms (KEMs). We specifically address the unique algebraic structure of the NTRU and NTRU Prime schemes, demonstrating how to extract information related to secret variables from side channels and modeled
Background: There is limited data on the organisation of paediatric echocardiography laboratories in Europe. Methods: A structured and approved questionnaire was circulated across all 95 Association for European Paediatric and Congenital Cardiology affiliated centres. The aims were to evaluate: (1) facilities in paediatric echocardiography laboratories across Europe, (2) accredited laboratories, (
