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Background: Stimulation of the immune system by gut microbes might prevent allergy development. Objective: The present study examined the hypothesis that sensitization to food allergens and atopic eczema are influenced by the infantile intestinal colonization pattern. Methods: Infants were recruited perinatally in Goteborg (n = 116), London (n = 108), and Rome (n = 100). Commensal bacteria were id

Vascular smooth muscle cells (VSMCs) in the intact vascular wall are differentiated for contraction, whereas the response to vascular injury involves transition towards a synthetic phenotype, with increased tendency for proliferation. Platelet-derived growth factor (PDGF) is thought to be important for this process. We investigated expression and functional coupling of PDGF receptors (PDGFRs) alph

Neuroblastoma is a childhood tumour derived from the sympathetic nervous system. Although most children with neuroblastoma initially respond to treatment, approximately 50% of these patients relapse with multidrug-resistant tumours. Arsenic trioxide (As2O3) has been used for centuries to treat different clinical disorders including malignancies. This drug has now attracted new attention since it h

Recently, hippocampal neuropeptide Y (NPY) gene therapy has been shown to effectively suppress both acute and chronic seizures in animal model of epilepsy, thus representing a promising novel antiepileptic treatment strategy, particularly for patients with intractable mesial temporal lobe epilepsy (TLE). However, our previous studies show that recombinant adeno-associated viral (rAAV)-NPY treatmen

Philosophers of science have often favoured reductive approaches to how-possibly explanation. This article identifies three alternative conceptions making how-possibly explanation an interesting phenomenon in its own right. The first variety approaches “how possibly X?” by showing that X is not epistemically impossible. This can sometimes be achieved by removing misunderstandings concerning the

In this report we have analysed the Scandinavian film and television culture focusing on films released between 2002-2006, using data drawn from both cinemas in Scandinavia and in the rest of Europe, as well as films shown on television in Denmark, Norway and Sweden. The study involves a comparative look at the support mechanisms and the production sector as well as the distribution sector, especi

Popular Abstract in Swedish FISKETS EFFEKTER BEROR PÅ SAMSPELET MELLAN ARTER Fiske och jakt, så kallad populationsbeskattning, påverkar den fiskade eller jagade populationen på en rad olika sätt. Den direkta effekten är uppenbar: dödligheten ökar, och antalet individer i populationen minskar. I förlängningen påverkar denna minskning också andra arter, som t ex äter eller äts av individerna i den bHarvesting changes population abundance and can affect adaptation of several life-history traits. Harvesting can also have indirect effects ? effects on non-target species and secondary effects on target species ? because interactions between species in a community determine the relevant ecological and evolutionary feedback environment. Species interactions therefore influence the effect of harves

This book studies the technognomies of memory in scripto as in texts, lists, dictionaries and databases and less the technognomies of memory in vivo (as in remembering). There are of course some relations between these two kinds of memories, being memory-in-scripto a development parallel to the development of written language. We notice that the historical presentation is built upon both forms of

Popular Abstract in Swedish Under de senaste 20 åren har större hänsyn tagits till den enskilde patientens önskningar och behov innan en behandling har påbörjats. Detta har skett parallellt med en snabb teknisk och medicinsk utveckling. Samtidigt som nya behandlingsmetoder tagits fram, har det också blivit angeläget att utvärdera effekten av dessa, vilket även inkluderar hur den enskilde individenFactors determining patient`s and doctor`s delay in diagnosis of bladder cancer were type of initial symptoms, level of health service first consulted and number of steps in the referral system. No correlation was found between psychosocial factors and patient`s delay. In retrospective studies after cystectomy for bladder cancer, patients with continent cutaneous diversion of urine had fewer stoma

Popular Abstract in Swedish Prostatacancer är idag den vanligaste sjukdomen hos män, och är den cancer form som leder till flest dödsfall bland män i Sverige (av de män som får diagnosen avlider 35% på grund av sjukdomen). Det har visats att risken att utveckla prostatacancer påverkas av ålder, etnicitet och diet (bla asiatisk mat och tomater verkar ha skyddande effekt), men också av genetiska fakProstate-specific antigen (PSA) is a worldwide used tool for the diagnosis and monitoring of prostate cancer. It is a serine protease and belongs to the family of glandular kallikreins. Humans have three classical glandular kallikreins, but it has been reported that rodents have many more. Lately, the family has been expanded to contain 12 new genes, KLK4–KLK15, that are situated at the same locus

Extremely large filled-aperture ground-based optical-IR telescopes, or ELTs, ranging from 20 to 100m in diameter, are now being proposed. The all-important choice of the aperture must clearly be driven by the potential science offered. We here highlight science goals from the Leiden Workshop in May 2001 suggesting that for certain critical observations the largest possible aperture - assumed to be

This thesis deals with cerebral arterial vasospasm and ischaemia, a serious complication after aneurysmal subarachnoid haemorrhage. Firstly is the noninvasive transcranial Doppler ultrasound and transcranial cerebral oximetry techniques evaluated in detecting cerebral arterial vasospasm in clinical practice. Patients were examined during first 14 days after the bleed. Flow velocities in normo- ver

Popular Abstract in Swedish Malign hypertermi, ärftligt och farligt vid narkos – hur diagnostiseras det ? I april 1960 sövdes en yngling i Australien. Han var mycket orolig därför att tio släktingar dött av eter-narkos. Han sövdes i stället med ett nytt medel – halotan, det höll på att kosta även honom livet. En kortfattad fallbeskrivning i Lancet fick stor uppmärksamhet och på andra ställen i väMalignant hyperthermia (MH) susceptibility is a rare inherited muscular disorder, which may cause a lethal increase in metabolism during anaesthesia with certain commonly used anaesthetic. Susceptible individuals are without any signs or symptoms. It is important to identify individuals at risk, since the MH reaction is preventable. Susceptibility to MH is diagnosed with an in vitro contracture te

Popular Abstract in Swedish Sjukdomar hos äldre har ofta annan sjukdomsbild än motsvarande sjukdom hos medelålders och yngre. Till exempel är symtomen är ofta mindre tydliga, äldre har ofta flera samtidiga sjukdomar som ger en komplex sjukdomsbild, dessutom kan ett ”mindre allvarligt” sjukdomstillstånd föra med sig betydande besvär pga annan samtidig sjukdom. Detta gäller även för depressionssjukd

This dissertation discusses the reception of Karl Barth in Swedish theology, with particular emphasis on the period since 1947. Harmonising tendencies arechar2cteristic of Swedish theology, and therefore, by its emphasis on discontinuity between I iod and man Barth's theology becomes the natural 'other' of Swedish theology. Barth's theoiogy is trivialised either through exclusion or through subsum

Nocturnal vision is a demanding task for insects with small eyes. As it gets dimmer the noise imposed by the stochastic nature of photon arrival makes vision unreliable. Despite this, there are quite a number of animal species that are active at night and apparently see well. In this thesis I show that the compound eyes of nocturnal insects are sufficiently flexible to adapt to the particular wind

Tachykinins have been implied as mediators and/or modulators of capsaicin-sensitive primary afferents. It is known that tachykinins are released from central endings of capsaicin-sensitive primary afferent neurons in the rat and cat spinal cords, and that the capsaicin-sensitive bladder afferents are involved in regulating the micturition reflex in the rat. The general aim of the present studies w

The aim of this paper is to study the extent to which non-Annex I countries are implementing or exploring select actions that support both climate change mitigation and sustainable development objectives in the energy sector. The research is based on a survey of the national communications of 100 non-Annex I Parties to the UNFCCC. Although national communications are intended to provide informatio