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Exploring the visual world of fossilized and modern fungus gnat eyes (Diptera : Keroplatidae) with X-ray microtomography

Animal eyes typically possess specialized regions for guiding different behavioural tasks within their specific visual habitat. These specializations, and evolutionary changes to them, can be crucial for understanding an animal's ecology. Here, we explore how the visual systems of some of the smallest flying insects, fungus gnats, have adapted to different types of forest habitat over time (approx

Uptake and degradation of iodine labelled chylomicron remnant particles by rat hepatocytye monolayers

1. Rat chylomicrons were labelled with 125I with 69--72% of the iodine in the protein moiety. Less than 1 nmol of iodine was incorporated per nmol of protein. Of the peptide radioactivity 44--56% was in apolipoprotein A-1, 30--40% in the C peptides and 11--15% in apolipoprotine B. The arginine-rich peptide, which accounted for about 14% of the chylomicron protein mass as determined by scanning of

Due Diligence versus Positive Obligations: Critical Reflections on the Council of Europe Convention on Violence against Women

Article 5 of the Council of Europe Convention on Preventing and Combating Violence against Women and Domestic Violence (the Istanbul Convention) enshrines the standard of due diligence to frame states’ obligations. In the existing literature in the area of violence against women, the standard of due diligence has been uncritically endorsed; the reason being that it has played a crucial role in the

Effective Interactions and Colloidal Stability of Bovine γ-Globulin in Solution

Interactions and phase behavior of γ-globulins are of fundamental interest in biophysical and pharmaceutical research, as these are among the most abundant proteins in blood plasma. In this work, we report the characterization of the oligomeric state of bovine γ-globulin, the effective protein–protein interactions, and the colloidal stability in aqueous solution as a function of protein concentrat

Cystatin C : a new marker of biocompatibility or a good marker for the redistribution of LMW proteins during hemodialysis?

The mechanism(s) behind the larger relative increase of Plasma beta 2 microglobulin (P-beta 2m) than that of Plasma albumin (P-alb) during Cuprophan hemodialysis is disputed. To elucidate this phenomenon P-alb, P-beta 2m (MW 11,800) and Plasma cystatin (P-cC; MW 13,000) an inhibitor of cystein proteinases, were determined before and after a Cuprophan or polysulphone hemodialysis (4-7 hr, QB 200 ml

Envisioning a resilient future for biodiversity conservation in the wake of the COVID-19 pandemic

As the COVID-19 pandemic continues to affect societies across the world, the ongoing economic and social disruptions are likely to present fundamental challenges for current and future biodiversity conservation. We review the literature for outcomes of past major societal, political, economic and zoonotic perturbations on biodiversity conservation, and demonstrate the complex implications of pertu

Long-term ecosystem nitrogen limitation from foliar δ15N data and a land surface model

The effect of nutrient availability on plant growth and the terrestrial carbon sink under climate change and elevated CO2 remains one of the main uncertainties of the terrestrial carbon cycle. This is partially due to the difficulty of assessing nutrient limitation at large scales over long periods of time. Consistent declines in leaf nitrogen (N) content and leaf δ15N have been used to suggest th

Allotted chambers as defenders of democracy

In this paper, we identify a problem—the problem of which actors should serve as defenders of democracy—and propose a solution to that problem—the creation of randomly selected citizen bodies, or allotted chambers (hereafter ACs).1 Having in place institutions that are tasked with democratic self-defense, is, we argue, a critically important pillar of democratic government, but its importance has

Decomposition analysis of per capita emissions : A tool for assessing consumption changes and technology changes within scenarios

Recent studies show that behaviour changes can provide an essential contribution to achieving the Paris climate targets. Existing climate change mitigation scenarios primarily focus on technological change and underrepresent the possible contribution of behaviour change. This paper presents and applies a methodology to decompose the factors contributing to changes in per capita emissions in scenar

Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease

Background: Pathology in the noradrenergic A6 locus coeruleus has not been compared with more rostral dopaminergic A9 substantia nigra and A10 ventral tegmental area, and cholinergic Ch4 basal nucleus and Ch1/2 septal regions in the same cases of Parkinson's disease (PD). Objective: To determine whether there is a gradient of caudal to rostral cell loss in PD. Methods: Postmortem brains were colle

High dose pollen intralymphatic immunotherapy : Two RDBPC trials question the benefit of dose increase

Background: The same dosing schedule, 1000 SQ-U times three, with one-month intervals, have been evaluated in most trials of intralymphatic immunotherapy (ILIT) for the treatment of allergic rhinitis (AR). The present studies evaluated if a dose escalation in ILIT can enhance the clinical and immunological effects, without compromising safety. Methods: Two randomized double-blind placebo-controlle

Fostering Knowledge uptake in Emerging Innovation Systems : Enhancing Conditions for Innovation in Rwanda

Knowledge, when used effectively, is a major input for development. However, the processes associated with knowledge production, knowledge transfer, and knowledge use are complex and not easy to facilitate in certain parts of the world. This is mainly due to a lack of or limited interactions between knowledge producers and knowledge users. This thesis aims to explore how efforts to foster knowledg

A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner

Activation of AMP-activated protein kinase (AMPK) is considered a valid strategy for the treatment of type 2 diabetes. However, despite the importance of adipose tissue for whole-body energy homeostasis, the effect of AMPK activation in adipocytes has only been studied to a limited extent and mainly with the AMP-mimetic 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside (AICAR), which has limited

Introduction in the Study of Romanian Language : A textbook for foreign students

Every of the seven chapters of the course aims at introducing the students to the basics of Romanian language in the larger context of the Romanian culture and civilization development, with the ultimate purpose of settling both a few essential theoretical knowledge and some practical communication skills for the foreign students as inhabitants of Romania. The compulsory tasks at the end of each c

The Similarity of Abundance Ratio Trends and Nucleosynthetic Patterns in the Milky Way Disk and Bulge

We compare abundance ratio trends in a sample of ∼11,000 Milky Way bulge stars (R GC < 3 kpc) from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) to those of APOGEE stars in the Galactic disk (5 kpc < R GC < 11 kpc). We divide each sample into low-Ia (high-[Mg/Fe]) and high-Ia (low-[Mg/Fe]) populations, and in each population, we examine the median trends of [X/Mg] versus [Mg/

Development of a hot-box test setup with dynamic outdoor climate

In Europe, all new houses built require an energy declaration showing the expected energy consumption during use. However, there is often a discrepancy between the calculated and the actual energy consumption. Some claim that in general the difference is on the positive side for wooden buildings, with real energy consumption being lower than predicted. This could be an effect of thorough and long-

Electronic correlations at paramagnetic (001) and (110) NiO surfaces : Charge-transfer and Mott-Hubbard-type gaps at the surface and subsurface of (110) NiO

We explore the interplay of electron-electron correlations and surface effects in the prototypical correlated insulating material, NiO. In particular, we compute the electronic structure, magnetic properties, and surface energies of the (001) and (110) surfaces of paramagnetic NiO using a fully charge self-consistent DFT+ dynamical mean-field theory method. Our results reveal a complex interplay b

Association of Enlarged Perivascular Spaces and Measures of Small Vessel and Alzheimer Disease

OBJECTIVE: To investigate the relationship between enlarged perivascular spaces (EPVS) and measures of Alzheimer disease (AD), small vessel disease (SVD), cognition, vascular risk factors, and neuroinflammation, we tested associations between EPVS and different relevant neuroimaging, biochemical, and cognitive variables in 778 study participants. METHODS: Four hundred ninety-nine cognitively unimp