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This study was undertaken to evaluate the role of transcytosis as a bulk transfer mechanism for the passage of albumin from blood to tissue. Isolated rat lungs were continuously weighed and perfused with an albumin-serum buffer solution under strictly controlled hemodynamic conditions, which allowed measurements of microvascular pressure and of the capillary filtration coefficient (LpS). With the
Popular Abstract in Swedish KLINISK, GENETISK OCH METABOLISK KARAKTERISERING AV LADA (LATENT AUTOIMMUNE DIABETES IN ADULTS) Diabetes mellitus, sockersjuka, har blivit en allt vanligare sjukdom över hela världen. Det finns totalt drygt 100 miljoner diabetiker idag och antalet förväntas åtminstone fördubblas till år 2010. Viktiga skäl till denna nästan epidemiska utveckling är livsstilsförändringar Latent autoimmune diabetes in adults (LADA) comprises about 10% of patients initially diagnosed with type 2 diabetes but who are positive for pancreatic islet antibodies, especially to glutamic acid decarboxylase (GADabs). The present studies focused on clinical, genetic and metabolic characterisation of patients with LADA. In LADA, the frequency of the type 1 diabetes susceptibility genotype HLA-
Blood pressure and pulsatile diameter changes of the abdominal aorta were measured in 68 children (mean age 9 years), with varying degrees of intrauterine growth retardation who were previously examined in their intrauterine life with Doppler velocimetry of the thoracic descending aorta. Diastolic blood pressure was lower (p < 0.05) and pulse pressure was increased (p < 0.01) in children with a bi
Bees are mostly active during the daytime, but nocturnality has been reported in some bee families. We studied temporal flight activity in three species of carpenter bees (genus Xylocopa) in relation to light intensities. X. leucothorax is diurnal, X. tenuiscapa is largely diurnal being only occasionally crepuscular, while X. tranquebarica is truly nocturnal. Occasional forays into dim light by X.
Although calcineurin inhibitors (CNIs) are effective at preventing a cute rejection, their long-term use is associated with nephrotoxicity that may compromise long-term renal allograft Survival. Consequently, there is considerable interest in identifying immunosuppressive regimens that permit reduced exposure to CNIs while maintaining adequate immunosuppression. Introducing such strategies early a
The new generation of extremely large telescopes will have adaptive optics. Due to the complexity and cost of such systems, it is important to simulate their performance before construction. Most systems planned will have Shack-Hartmann wavefront sensors. Different mathematical models are available for simulation of such wavefront sensors. The choice of wavefront sensor model strongly influences c
It is well known that Max-Weight type scheduling algorithms are throughput optimal since they achieve the maximum throughput while maintaining the network stability. However, the majority of existing works employing Max-Weight algorithm require the complete channel state information (CSI) at the scheduler without taking into account the associated overhead. In this work, we design a Scheduling and
n order to protect their food from competitors, ball-rolling dung beetles detach a piece of dung from a pile, shape it into a ball, and roll it away along a straight path [1]. They appear to rely exclusively on celestial compass cues to maintain their bearing [2, 3, 4, 5, 6, 7 and 8], but the mechanism that enables them to use these cues for orientation remains unknown. Here, we describe the orien
The Swedish Orthopaedic Society held its meeting on September 10-12,1986, in Östersund, which is situated on a large lake in central Sweden. This year, Ostersund celebrated its bicentennial; but more than 1,000 years ago the Vikings had a center here to worship their gods, as well as a fortress on the neighboring island of Frösö. Today, Östersund is the gateway to Sweden's most popular winter recr
The highly poisonous botulinum neurotoxins, produced by the bacterium Clostridium botulinum, act on their hosts by a high-affinity association to two receptors on neuronal cell surfaces as the first step of invasion. The glycan motifs of gangliosides serve as initial coreceptors for these protein complexes, whereby a membrane protein receptor is bound. Herein we set out to characterize the carbohy
Understanding how drugs work is of great importance, since it can facilitate drug discovery, both time- and costwise. At the same time, it is important to have methods that can help predict how well does a potential drug molecule bind to its target. Computational methods can in many ways contribute to drug design process. In this thesis, we employ different computational approaches to study the bi
Aim: The aim of this study was to explore the meaning of family members’ experience of waiting in an intensive care context using Rodgers’ evolutionary method of concept analysis. Method: Systematic searches in CINAHL and PubMed retrieved 38 articles which illustrated the waiting experienced by family members in an intensive care context. Rodgers’ evolutionary method of concept analysis was applie
This thesis aims to examine how the EC law regarding asylum and refugees, or more precisely how the notion of “safe countries” and the definition of “refugee” in the Asylum Procedures Directive and the Qualification Directive, affect the Roma minority in Europe. The theoretical framework is based on two theories: One theory is Etienne Balibar’s discussion concerning the European project and how it
INTRODUCTION RealQ-KML is a clinical decision support system combined with tools for quality assessment for chronic myeloid leukemia (CML). Thanks to the introduction of modern treatment CML is a chronic disease, which during its follow-up generates large quantities of data. The aim of this study was to evaluate how this program could be used at the Department of Hematology, at Skåne University Ho
This essay will explore the challenges which can occur for consultants employed by a staffing company while being placed at the same host company for a longer period of time. These challenges occur due to the fact that the Swedish Labour Law is not framed for the three party relationship between employer, consultant and host company which an employment at a staffing company creates. Hiring of pers
Since 2008, a picture is emerging of a global rush of the world’s farmland, referred to as land acquisition. Several factors underpin these land acquisitions such as the financial crisis and the food prices hikes of 2007/8. Another key driver behind the deals is the biofuel boom that has been a major cosmopolitical topic the last few years. Land acquisition refers to when a wealthier nation, firm
