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Stretch of vascular smooth muscle stimulates growth and proliferation as well as contraction and expression of contractile/cytoskeletal proteins, all of which are also regulated by calcium-dependent signals. We studied the role of the calcium- and integrin-activated proline-rich tyrosine kinase 2 (PYK2) in stretch-induced responses of the rat portal vein loaded by a hanging weight ex vivo. PYK2 ph
Background Many public health and epidemiological studies have found differences between populations (e.g. maternal countries of birth) in average values of a health indicator (e.g. mean offspring birthweight). However, the approach based solely on population-level averages compromises our understanding of variability in individuals’ health around the averages. If this variability is high, the ex
A Norway spruce (Picea abies Karst) forest site in southwest Sweden was chosen to study the effects of storm disturbances over the period 1997-2009, during which two storms, 'Lothar' (December 1999) and 'Gudrun' (January 2005), affected the area. Monitored deposition data, soil water chemistry data and forest inventory data were compared with the predictions of an integrated ecosystem model, ForSA
Background: The objective was to understand patients' views of treatment after acute anterior cruciate ligament (ACL) injury, and their reasons for deciding to request surgery despite consenting to participate in a randomised controlled trial (to 'cross-over'). Methods: Thirty-four in-depth qualitative interviews were conducted with young (aged 18-35), physically active individuals with ACL ruptur
Objective Two functional single nucleotide polymorphisms (SNP) in the PTPN22 gene (rs24746601 and rs33996649) have been associated with autoimmunity. The aim of this study was to investigate the role of the R263Q SNP for the first time and to re-evaluate the role of the R620W SNP in the genetic predisposition to systemic sclerosis (SSc) susceptibility and clinical phenotypes. Methods 3422 SSc pati
Objectives: To assess the prevalence of pharyngeal and oesophageal symptoms and dysmotility in patients with primary Sjogren's syndrome ( pSS) and relate these to autonomic nervous function. Methods: Twenty consecutive pSS patients, according to the American - European Consensus Criteria ( AECC), and 30 age- and sex- matched controls from the Swedish general population registry were studied. All s
Reliable performance evaluation of wastewater treatment plants (WWTPs) can be done by simulating the plant behavior over a wide range of influent disturbances, including series of rain events with different intensity and duration, seasonal temperature variations, holiday effects, etc. Such simulation-based WWTP performance evaluations are in practice limited by the long simulation time of the mech
Objective S100B is viewed as the most promising biomarker for brain damage. It has been proposed that this marker is useful in a Neurointensive Care Unit (NICU) as a monitoring parameter. This study aims to examine the clinical usefulness of daily serum S100B measurements in this setting. Design Prospective consecutive inclusion of patients. Patients A total of 79 patients with confirmed or suspec
BACKGROUND: Because of the limited supply of donor hearts, prospective recipients continue to die while on the waiting list for heart transplantation. Use of long-term mechanical circulatory support devices as a bridge to transplantation may reduce this mortality. However, with the present state of technology, continued clinical evaluation of the various long-term, mechanical circulatory support d
Helicobacter pylori attaches via lectins, carbohydrate binding proteins, to the carbohydrate residues of gastric mucins. Guinea-pigs are a suitable model for a H. pylori infection and thus the carbohydrate composition of normal and H. pylori infected gastric mucosa was investigated by lectin histochemistry. The stomach of all infected animals showed signs of an active chronic gastritis in their mu
Background Exposure to Benzodiazepines (BZD) during foetal life has been suggested to contribute to neonatal morbidity and some congenital malformations, for example, orofacial clefts. Here we aimed to study the neonatal outcome and congenital malformations in neonates whose mothers reported use of BZD and/or hypnotic benzodiazepine receptor agonists (HBRA) during pregnancy. Methods In the Swedish
A study in cats has shown that intracameral injection of calcitonin gene-related peptide (CGRP) increases the outflow facility by four- to fivefold concomitant with a decrease in intra-ocular pressure (IOP). Since there are great differences in the anatomy of the aqueous outflow routes between cats and primates, we have examined the effects of CGRP in the cynomolgus monkey. The possible influence
Background Postoperative policies of "wait-and-see" and radiotherapy for low-grade glioma are poorly defined. A trial in the mid 1980s established the radiation dose. In 1986 the EORTC Radiotherapy and Brain Tumor Groups initiated a prospective trial to compare early radiotherapy with delayed radiotherapy. An interim analysis has been reported. We now present the long-term results. Methods After s
In this study we present the results from realistic N-body modelling of massive star clusters in the Magellanic Clouds. We have computed eight simulations with N similar to 10(5) particles; six of these were evolved for at least a Hubble time. The aim of this modelling is to examine in detail the possibility of large-scale core expansion in massive star clusters, and search for a viable dynamical
Screening of 29 strains of Neisseria gonorrhoeae revealed that 16/21 serum resistant strains and 0/8 serum sensitive strains bound C4bp. suggesting that C4bp binding to gonococci could contribute to serum resistance. C4bp bound to gonococci retained cofactor (C4b-degrading) function. Using allelic exchange to construct strains with hybrid Por1A/B molecules, we demonstrate that the N-terminal loop
Across large spatial scales, species richness in many taxa is mainly determined by climatic variables. However, some of the mechanisms behind large-scale patterns of species richness and abundance are expected to act on the community level, and on a smaller scale than the resolution of the data commonly used for deriving these patterns. We studied the distribution of sheetweb spiders (Araneae: Lin
An improved Volume of Fluid (VOF) method is presented which is applicable to high density ratio 3D flows for a large range of bubble Reynolds number (Re). The method is based on the Navier-Stokes equations for incompressible multi-phase flows which are discretized on a Cartesian staggered grid. The multi-grid technique together with the pressure-velocity coupling scheme for multi-phase flows have
Electrochemical methods employing the hanging mercury drop electrode were used to study the interaction between variants of the complement-derived antimicrobial peptide CNY21 (CNYITELRRQH ARASHLGLAR) and dioleoyl phosphatidylcholine (DOPC) monolayers. Capacitance potential and impedance measurements showed that the CNY21 analogues investigated interact with DOPC monolayers coating the mercury drop
