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The purpose of this article is to contribute to a refined perspective on how the practices of everyday life can challenge existing spatial scale relations, as well as produce new ones, and how this in turn can be addressed by planning. The investigation is based on a discussion of empirical studies dealing with the role of migrants in processes of place-making and urban transformation. In the arti
Current immune-based therapies signify a major advancement in cancer therapy; yet, they are not effective in the majority of patients. Physically based local destruction techniques have been shown to induce immunologic effects and are increasingly used in order to improve the outcome of immunotherapies. The various local destruction methods have different modes of action and there is considerable
Abstract Transition metals, such as zinc, are essential micronutrients in all organisms, but alsohighly toxic in excessive amounts. Heavy-metal transporting P-type (PIB) ATPases are crucial forhomeostasis, conferring cellular detoxification and redistribution through transport of these ionsacross cellular membranes. No structural information is available for the PIB-4-ATPases, the subclasswith the
AIMS: Patients awaiting orthotopic heart transplantation (OHT) can be bridged utilizing a left ventricular assist device (LVAD) that reduces left ventricular filling pressures, decreases pulmonary artery wedge pressure, and maintains adequate cardiac output. This study set out to examine the poorly investigated area of if and how pre-treatment with LVAD impacts right ventricular (RV) function foll
I report on the opening ceremony of the International Year of Light and Light-based Technologies 2015 (IYL2015), which took place at the UNESCO headquarters in Paris, France, on 19-20 January 2015. Over the two days, more than 1000 participants from all over the world learned more about the fundamental properties of light and advanced photonics applications, the history of optics and its applicati
We report the synthesis of linear and branched (1→4)-d-galactans. Four tetrasaccharides and one pentasaccharide were accessed by adopting a procedure of regioselective ring opening of a 4,6-O-naphthylidene protecting group followed by glycosylation using phenyl thioglycoside donors. The binding of the linear pentasaccharide with galectin-3 is also investigated by the determination of a co-crystal
We examine whether international trade improves labour market integration of immigrants in Sweden. Immigrants participate substantially less than natives in the labour market. However, trading with a foreign country is expected to increase the demand for immigrants from that country. By hiring immigrants, a firm may access foreign knowledge and networks needed to overcome information frictions in
Simultaneous Digital Breast Tomosynthesis (DBT) and mechanical imaging (MI), called DBTMI, is a novel breast imaging method aimed at improving sensitivity and specificity of breast cancer screening. DBTMI combines improved cancer detection by three-dimensional DBT imaging, with the analysis of local stress over the compressed breast by MI, which can reduce false positive findings. The MI signal is
Although Benjamin Schnieder’s theory of the “ordinary conception” of properties successfully handles paradoxical properties—particularly, the property of non-self-instantiation—it fails to account for ordinary, non-pathological cases. The theory allows the inference of ‘a has the property of being F’ only given F(a) and the prior assertibility of ‘the property of being F can exist’. While this all
Introduction. Recently, more attention is being paid to the drug-induced liver injury (DILI) as a consequence of the tuberculos is treatment and the need for new medicine is emphasized. The use of isoniazid and rifampicin has a potentiating effect, which increases the risk of substancial liver damage. In turn, systemic accumulation of toxic metabolites leads to negative changes in various organs,
We discuss two approaches for the formulation and implementation of space-time discontinuous Galerkin spectral element methods (DG-SEM). In one, time is treated as an additional coordinate direction and a Galerkin procedure is applied to the entire problem. In the other, the method of lines is used with DG-SEM in space and the fully implicit Runge–Kutta method Lobatto IIIC in time. The two approac
The purpose of this study was to describe neuromuscular and kinematic differences during failed and successful drop-vertical jumps in a pediatric population. Healthy young athletes (n = 32) completed single-leg drop vertical jump landings where the required landing leg was unanticipated. Trials were categorized as failed if the participant shifted their base of support during the landing. Joint ki
Motivational strategies are underresearched, and studies so far conducted have been in sociolinguistic contexts where English is not extensively encountered outside the classroom. Given also that little is known about strategies relating to the design and content of classroom activities, the purpose of this study is to identify and critically evaluate strategies focusing on activity design and con
TAR DNA-binding protein-43 (TDP-43) accumulation is the primary pathology underlying several neurodegenerative diseases. Charting the progression and heterogeneity of TDP-43 accumulation is necessary to better characterize TDP-43 proteinopathies, but current TDP-43 staging systems are heuristic and assume each syndrome is homogeneous. Here, we use data-driven disease progression modelling to deriv
The semiconductor technology development con- stantly enables integrated circuits (ICs) with more, faster and smaller transistors. While there are many advantages, there are also many and new challenges, for example tighter margins, wear- outs and process variations. To address these challenges, the traditional approach with external test instruments used at man- ufacturing test must be complement
The work focuses on analysis and development of integrated low-pressure shaft generator in a geared twin-spool turbofan engine. It starts with manufacturing and evaluation of direct cooled hollow conductor coils, and has focus manufacturing, assembling and integration issues essential to machine design. The experiment-in-loop, but the model-based evaluation focuses not only on the coolant and cool
